p16蛋白在子宫内膜癌中表达的研究

为探讨P16基因在子宫内膜癌发生及发展过程中所起的作用,采用免疫组化SP法对38例子宫内膜癌(腺癌33例,腺棘皮癌4例,浆液性乳头状腺癌1例)及19例正常组织进行了p16蛋白的免疫组化检测,结果p16蛋白在正常组织中表达率为56.8%,在腺癌中的表达率为21.7%,在腺棘皮和浆液性乳头腺癌中的表达率为25.1%,与正常组差异显著,同时,p16蛋白在Ⅰ-Ⅱ期子宫内膜中的表达率为26.4%。而在Ⅲ-Ⅳ期子宫内膜癌中的表达率为11.7% ,二者差异显著,说明p16蛋白在子宫内膜癌的发生及进展过程中起重要作用。 Abstract:To understand the role of P16 gene in the progression of carcinoma of endometrium,the expression of P16 gene was detected in 38 carcinoma of endometrium specimens and 19 controls by immunhistochemical SP method.The p16 protein positive rates of carcinoma of endometrium and control had significant difference (P<0.05),and the expression of p16 protein was also significant different between I～II grades and III～IV grades of adenocarcinoma of endometrium.So the p16 protein was closely associated with the generation and development of the carcinoma of endometrium.