链霉菌AC-57及其产生的阿克拉霉素A的研究

During the course of screening for new antitumor antibiotics, a new anthracycline antibiotic--aclacinomycin A was separated from the broth and mycelium of Streptomyces AC-57. The strain AC-57 was isolated from the soil collected in the Shanghai suburbs. According to its culture and physiological characteristics the producer was identified as Str. galilaeus AC-57. The broth and mycelium were extracted and treated with solvents as usual way. The aclacinomycin A was separated by silica-gel column chromatography eluted with chrolo-form-methanol. Aclacinomycin A, its aglycone and sugar components were identified by comparison of their physico-chemical and spectral data (MS, UV, IR, 1H-NMR, and 13C-NMR) with authentic compound, purified from the market sample.     

大环内酯类抗生素X-7的研究II．抗生素X-7-III的分离、纯化和鉴定

我们从一株北里轮链丝菌崇明变种Streptoverticillium kitasatoensls var chongmingense n.var．X-7的发酵液中,分离纯化得到五个组分,其中组分HI为一白色结晶,对革兰氏阳性细菌有作用,系碱性大环类抗生素,其理化性质与国外临床上广泛使用的柱晶白霉素Lcucomyci A3[1-4,6]相同。     

链霉菌72产生的二个代谢产物

本文报道从一株属于吸永类群放线菌的链霉菌72(Streptomycessp．No．72)发酵液中,分离到二个抗菌物质。其中一个抗真菌,经各种理化数据鉴别确定为放线酚(A．Ctiphcn)抗肿瘤活性筛选结果表明它对实验动物肿瘤有一定抑制作用。另一个具有抗细菌作用,亦经各种理化数据测定鉴定为苯7J酸酰胺。