首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   340篇
  免费   36篇
  国内免费   11篇
  2023年   7篇
  2022年   7篇
  2021年   14篇
  2020年   16篇
  2019年   13篇
  2018年   9篇
  2017年   13篇
  2016年   12篇
  2015年   18篇
  2014年   11篇
  2013年   26篇
  2012年   6篇
  2011年   12篇
  2010年   9篇
  2009年   11篇
  2008年   15篇
  2007年   21篇
  2006年   10篇
  2005年   14篇
  2004年   19篇
  2003年   11篇
  2002年   10篇
  2001年   8篇
  2000年   7篇
  1999年   6篇
  1998年   5篇
  1997年   8篇
  1996年   8篇
  1995年   7篇
  1993年   4篇
  1992年   3篇
  1991年   3篇
  1990年   2篇
  1989年   8篇
  1988年   7篇
  1987年   2篇
  1986年   4篇
  1985年   2篇
  1984年   1篇
  1983年   4篇
  1982年   5篇
  1981年   1篇
  1980年   1篇
  1979年   2篇
  1978年   1篇
  1977年   1篇
  1976年   1篇
  1975年   1篇
  1971年   1篇
排序方式: 共有387条查询结果,搜索用时 31 毫秒
1.
目的:比较血小板生成素与白介素-11治疗胃癌患者术后化疗血小板减少症的时效和安全性。方法:术后辅助化疗出现血小板计数低于75×109/L的进展期胃癌患者68例,将其分为TPO组与IL-11组,分别为35例和33例。分别皮下注射rhTPO 15000U,每日1次;rhIL-11 1.5 mg,每日1次,当血小板计数125×109/L或比用药前上升50×109/L,即停止给药,疗程最长为14天。每3天抽取外周静脉血2 m L,通过全自动血液分析仪测定血小板计数,密切观察出现的不良反应并记录。比较两组患者不同临床病理资料、血小板计数、血小板计数升至75×109/L和125×109/L的时程、药物不良反应。结果:两组患者年龄、性别、化疗方案、血小板最低值出现的化疗周期及临床病理分期的比较均没有统计学差异(P值均0.05)。TPO组与IL-11组血小板动态值的比较,第9天出现显著差异(P=0.032)。TPO组与IL-11组血小板计数恢复至75×109/L和125×109/L所需的时间,有显著差异(P=0.041,P=0.013)。TPO组中,有3例(8.6%)患者发生不良反应,IL-11组中,有13例(39.4%)患者发生不良反应,TPO组患者出现的不良反应少且较轻微(P=0.006)。结论:rhTPO治疗胃癌患者术后化疗血小板减少症时效快,安全性好。  相似文献   
2.
3.
The present study assessed the suitability of titanium(IV) oxide, TiO2, as a digesta passage marker in Nile tilapia Oreochromis niloticus and studied the shape of the evacuation curve in this species. In three separate trials, fish were given one dose of either 0·5, 0·25 or 0·1% of their body mass (% BME) of feed marked with 1% TiO2 or 0·5% BME of the same feed without marker. The fish were serially slaughtered at intervals after feeding and the stomach contents analysed for dry mass and marker content. The data for individual trials were analysed with the linear, square root, surface area and exponential evacuation models and parameter comparisons showed that, although the marker interfered slightly with the evacuation process, true meal size could be predicted more accurately from the marker data. The results of an analysis of the combined data sets suggested that stomach evacuation in this species is dependent more on food particle surface area (surface area model) than on stomach content mass (exponential model) as is generally assumed. On the basis of these results, it was concluded that TiO2 at an inclusion level of 1% is an acceptable marker for quantifying evacuation with a view to predicting food consumption but should be used with caution in digestibility studies.  相似文献   
4.
Ontogeny of lipase expression in winter flounder   总被引:3,自引:0,他引:3  
The partial sequencing of two lipases from winter flounder Pseudopleuronectes americanus , one most closely related to gastric, lingual and lysosomal acid lipase from other vertebrates and one most closely related to bile salt-activated lipase, is reported. Biochemical analyses of enzymatic activity demonstrated the greater contribution made by bile salt-activated lipase relative to neutral bile salt-independent lipase. Using molecular techniques, the tissue-specific expression of bile salt-activated lipase in pancreatic tissue and acid triacylglycerol lipase in a wide variety of organs was demonstrated. Furthermore, the developmental expression of these types of lipase in larval fish was established.  相似文献   
5.
电离辐射引起胃排空延迟机理的初步探讨   总被引:1,自引:0,他引:1  
本文观察了800rad照射后胃肠肌电的变化及切斷内脏神经与电刺激迷走神经对官的影响,初步分析了电离辐射引起胃排空延迟的机理。结果是:800rad照后大鼠胃肠肌电的峰波平均振幅胃幽部窦部照后1小时至第4天明显降低(P<0.05);幽门括约肌政变不大;十二指肠球部照后第3~7天明显下降(P<0.01)。切断内脏神经后照射大鼠胃肠肌电的峰波平均振幅胃幽门窦部变化不大,幽门括约肌照后1小时至第5天明显升高(P<0.05),十二指肠球部照后第3~7天明显下降(P<0.05)。800rad照后第4天大鼠胃对电刺激迷走神经的反应性明显降低(P<0.01)。上述结果表明:照后胃排空延迟的原因不仅与神经-体液调节紊乱有关,而且与射线损伤了平滑肌,使其兴奋性暂时的功能性降低有关。此外照后由于十二指肠球部运动的变化而使内感受器对胃运动的调节发生紊乱也是值得重视的因素。  相似文献   
6.
Stomach cells of female Asplanchna sieboldi are specialized for absorption and intracellular digestion of nutrients. Evidence is presented to show that electron-opaque colloidal substances, present in the medium and within digestive vacuoles of the prey (Paramecium), are taken up by the stomach cells at the apical cell membrane and sequestered within food vacuoles which contain hydrolases working in both the acid and alkaline pH range. The stomach cells are also implicated in the absorption of molecules below the resolving power of the electron microscope. In rotifers possessing a complete digestive tract, this task is presumed to be handled by the intestine.  相似文献   
7.
PLS-ANN判别分析自体荧光光谱识别胃癌   总被引:4,自引:2,他引:2  
本文对58例胃癌病人离体标本的癌浆膜和正常浆膜进行以308nm为激发光的自体荧光光谱检测,采用多因素分析法进行光谱信息提取,以识别胃癌。研究表明偏最小二乘法结合神经网络法(简称PLS—ANN)进行判别分析,诊断胃癌的灵敏度为86%,特异度为100%,准确率为93%,有望成为手术中快速识别胃癌在胃壁的浸润范围的有效方法。  相似文献   
8.
The life history of Risso's dolphins (Grampus griseus) remains poorly known and data from strandings can help provide important information. Data from 126 Risso's dolphins stranded or bycaught along the southeastern coastline of South Africa between 1958 and 2017 were analyzed in relation to their sex, age structure, and diet. Mean estimated length at birth was 146.9 cm, while maximum length was 325 cm for males and 313 cm for females; small sample sizes precluded detailed examination of sexual dimorphism. Age estimates for 33 individuals (14 males, 17 females, 2 unknown sex) indicated a maximum age of 13 years (males) and 17 years (females), respectively; the oldest animal was 19 years (unknown sex). Mean length and age at attainment of sexual maturity were estimated at 280 cm and 7.1 years in males and at 282 cm and 7.7 years in females. Stomach contents from 27 individuals showed that diets of immature and mature males and females overlapped and consisted predominantly of cephalopods. Reported strandings decreased between 2000 and 2017, possibly due to a lack of reporting associated with a ban on driving on beaches or related to the collapse of the local “chokka” squid (Loligo reynaudii) fishery in 2014–2015.  相似文献   
9.
目的:对比管状胃代食管术与全胃代食管术治疗食管癌的安全性与有效性。方法:2005年1月到2015年2月选择我院收治的100例食管癌患者,根据随机数字表法分为治疗组与对照组各50例,所有患者都行食管癌切除术,同时对照组给予全胃代食管手术,治疗组给予管状胃代食管术,对两组患者围手术指标、并发症及生活质量状况进行观察比较。结果:所有患者完成手术,治疗组的手术时间、术中出血量、术后住院时间、术后胃肠减压时间及术后闭式引流时间都明显少于对照组(P0.05)。治疗组术后3个月反流性食管炎、胃排空障碍、胸胃综合征、吻合口狭窄、吻合口瘘等并发症发生情况明显少于对照组(P0.05),日常生活、一般状况、治疗相关症状、社会影响、情感活动评分都明显高于对照组(P0.05)。结论:相对于全胃代食管术,管状胃代食管术在治疗食管癌患者中的应用具有更好的安全性与有效性,值得进一步临床研究与推广。  相似文献   
10.
  1. The rate of non‐native fish introductions into freshwater ecosystems has more than doubled during the past three decades, posing a serious threat to native biodiversity. Despite potential benefits for fisheries, little is known about how introduced species interact with native communities at the food‐web level, or impact energy transfer dynamics and accumulation of contaminants in lake ecosystems.
  2. Here, we explored the trophic structure of a large, oligotrophic subarctic lake and assessed the trophic niche use and potential ecosystem‐wide consequences of two introduced salmonid species: piscivorous lake trout (Salvelinus namaycush) and zooplanktivorous vendace (Coregonus albula). We used a combination of diet, stable isotope and total mercury concentration data to test the hypotheses that the introduced fishes: (i) show partial niche overlap with the native fish community; (ii) increase total isotopic food‐web size and dietary linkages by increasing the diversity of niches present within the system, in comparison to analyses where only the native species were considered; and (iii) have differing mercury bioaccumulation rates from native species due to differences in trophic ecology and habitat preferences, being higher in pelagic than in littoral species.
  3. Trophic interactions between the introduced and native species were extensive, with evidence of reciprocal predation, resource competition and possible competitive exclusion apparent. Despite partial niche overlap with native species, the inclusion of introduced species in our analysis increased both total isotopic niche space and the number of dietary linkages present in the food web. On the basis of these findings, we suggest that introduced vendace may have led to a shift in system‐wide reliance on pelagically derived energy, whereas generalist foraging by piscivorous lake trout may have further integrated littoral and pelagic food‐web compartments. Mercury bioaccumulation rates were highly species‐specific and varied among habitats, but were generally higher in the pelagic food‐web compartment. However, contrary to expectations, vendace had lower mercury levels than native pelagic species, potentially reducing the extent of biomagnification within the lake.
  4. Our study demonstrates how introduced fishes may elicit complex and unpredictable responses in food‐web structure and ecosystem function, and thus complicate contaminant bioaccumulation and transfer processes within freshwater ecosystems.
  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号