Validation of the first step of the heuristic refinement method for the derivation of solution structures of proteins from NMR data

A new method for the analysis of NMR data in terms of the solution structure of proteins has been developed. The method consists of two steps: first a systematic search of the conformational space to define the region allowed by the initial set of experimental constraints, and second, the narrowing of this region by the introduction of additional constraints and optional refinement procedures. The search of the conformational space is guided by heuristics to make it computationally feasible. The method is therefore called the heuristic refinement method and is coded in an expert system called PROTEAN. The paper describes the validation of the first step of the method using an artificial NMR data set generated from the known crystal structure of sperm whale carbon monoxymyoglobin. It is shown that the initial search procedure yields a low-resolution structure of the myoglobin molecule, accurately reproducing its main topological features, and that the precision of the structure depends on the quality of the initial data set.     

Undergraduate Music Program Alumni's Career Path,Retrospective Institutional Satisfaction,and Financial Status

The purpose of this study was to examine undergraduate music education and performance alumni's career path, retrospective institutional satisfaction, and financial status. Data for this study were drawn from respondents from the 2010 administration of the nationwide, multi-institutional survey conducted by the Strategic National Arts Alumni Project (SNAAP). Regarding career path, nearly half of the music performance degree graduates reported performing as their current job, and slightly more than half of the music education degree graduates reported working in K–12 schools. Participants were generally satisfied with their institutional experiences, although relatively low levels of satisfaction were reported for networking and career advising services. The respondents reported being most satisfied with aspects of their current jobs that reflected the intrinsic benefits of contributing to a greater good, satisfying personal interests and values, and opportunities to be creative. The majority of the sample reported accruing student loan debt ranging between $10,000 and $30,000; however, no significant differences were found between groups, and 40 percent of the participants reported having accrued no debt at all. The reported annual income of the participants varied significantly, with music educators reporting higher earnings than performers.     

Extending a Model of Shift‐Work Tolerance

The present study contributes to theory and practice through the development of a model of shift‐work tolerance with the potential to indicate interventions that reduce nurses' intention toward turnover and increase job satisfaction in hospital‐based settings. Survey data from 1257 nurses were used to conduct structural equation modeling that examine the direct and indirect effects of supervisor and colleague support, team identity, team climate, and control over working environment on time‐based work/life conflict, psychological well‐being, physical symptoms, job satisfaction, and turnover intention. The analysis of the proposed model revealed a good fit The chi‐square difference test was non‐significant (χ²(26)=338.56), the fit indices were high (CFI=.923, NFI=.918, and NNFI=.868), the distribution of residuals was symmetric and approached zero, the average standardized residual was low (AASR=.04), and the standardized RMR was. 072. In terms of the predictor variable, the final model explained 48% of the variance in turnover intention. The data revealed considerable evidence of both direct effects on adjustment and complex indirect links between levels of adjustment and work‐related social support, team identity, team climate, and control. Nurses with high supervisor and coworker support experienced more positive team climates, identified more strongly with their team, and increased their perceptions of control over their work environment. This in turn lowered their appraisals of their time‐based work/life conflict, which consequently increased their psychological well‐being and job satisfaction and reduced their physical health symptoms and turnover intention. The type of shift schedule worked by the nurses influenced levels of turnover intention, control over work environment, time‐based work/life conflict, and physical symptoms.     

护理干预对骨科患者术后两种镇痛效果及满意度的影响

目的:探讨护理干预对骨科患者术后使用硬膜外持续微量注射镇痛及静脉自控微量注射镇痛效果的影响.方法:根据研究要求将患者按硬膜外持续微量注射镇痛及静脉自控微量注射镇痛方式分为实验组A、B组和对照组A、B组,实验组给予护理干预,对照组给予常规护理,然后对比两种术后镇痛方式护理干预组与常规护理组之间的镇痛满意度.结果:通过分析、比较,硬膜外持续微量注射镇痛患者及静脉自控微量注射镇痛患者镇痛满意度护理干预实验组均明显高于常规护理对照组.结论:常规的硬膜外持续微量注射镇痛及静脉自控微量注射镇痛使患者术后取得镇痛效果的过程中,系统的护理干预是提高镇痛满意度的重要因素.     

Hounds and Homesickness: The Effects of an Animal-assisted Therapeutic Intervention for First-Year University Students

Transitioning from high school to university can prove to be a for midable challenge for many first-year students, with many experiencing home sickness. Given that students who experience homesickness are more likely than their non-homesick cohorts to drop out of university, universities have a vested interest in supporting students during their first-year transition. Programs that provide opportunities for human–animal interactions on campus are gaining popularity as one way of increasing students’ wellbeing. The current study examined the effects of an 8-week animal-assisted therapy (AAT) program on first-year university students’ wellbeing. An initial feasibility study (n = 86) was conducted that provided opportunities for students to interact, in small groups, with trained therapy dogs and their volunteer handlers. Results indicated that this program reduced participants’ levels of homesickness and increased their satisfaction with life. An experimental study was then conducted utilizing a similar 8-week group AAT program. Participants (n = 44) were assigned to either a treatment condition (i.e., the AAT program) or to a no-treatment condition (akin to a wait-list control). At the end of the eight weeks, participants in the AAT program reported greater reductions in homesickness and greater increases in satisfaction with life than did those in the no-treatment condition. From beginning to end of the program, participants in the treatment group evidenced reductions in homesickness and increases in satisfaction with life and connectedness to campus, while participants in the no-treatment condition evidenced an increase in homesickness and no changes in satisfaction with life and connectedness to campus. Results of both the feasibility study and the experimental study support the use of AAT programs to increase the wellbeing of first-year university students experiencing homesickness.     

Taking the pulse of nations: A biometric measure of well-being

A growing literature identifies associations between subjective and biometric indicators of wellbeing. These associations, together with the ability of subjective wellbeing metrics to predict health and behavioral outcomes, have spawned increasing interest in wellbeing as an important concept in its own right. However, some social scientists continue to question the usefulness of wellbeing metrics. We contribute to this literature in three ways. First, we introduce a biometric measure of wellbeing – pulse – that hs been little used. Using nationally representative data on 165,000 individuals from the Health Survey for England and Scottish Health Surveys we show that its correlates are similar in a number of ways to those for happiness, and that it is highly correlated with wellbeing metrics, as well as self-assessed health. Second, we examine the determinants of pulse rates in mid-life (age 42) among the 9000 members of the National Child Development Study, a birth cohort born in a single week in 1958 in Britain. Third, we track the impact of pulse measured in mid-life (age 42) on health and labor market outcomes at age 50 in 2008 and age 55 in 2013. The probability of working at age 55 is negatively impacted by pulse rate a decade earlier. The pulse rate has an impact over and above chronic pain measured at age 42. General health at 55 is lower the higher the pulse rate at age 42, while those with higher pulse rates at 42 also express lower life satisfaction and more pessimism about the future at age 50. Taken together, these results suggest social scientists can learn a great deal by adding pulse rates to the metrics they use when evaluating people’s wellbeing.     

People versus machines: The impact of being in an automatable job on Australian worker’s mental health and life satisfaction

This study explores the effect on mental health and life satisfaction of working in an automatable job. We utilise an Australian panel dataset (HILDA), and take a fixed effects linear regression approach, to relate a person being in automatable work to proxies of their wellbeing. Overall, we find evidence that automatable work has a small, detrimental impact on the mental health and life satisfaction of workers within some industries, particularly those with higher levels of job automation risk, such as manufacturing. Furthermore, we find no strong trends to suggest that any particular demographic group is disproportionately impacted across industries. These findings are robust to a variety of specifications. We also find evidence of adaptation to these effects after one-year tenure on the job, indicating a limited role for firm policy.     

Non‐verbal mate retention behaviour in women and its relation to couple's relationship adjustment and satisfaction

The function of mate retention strategies is to preserve the bond between romantic partners and to prevent desertion, which is also why such behaviours are often elicited by the presence of a potential rival. Most existing studies on mate retention are based on self‐reports, which are prone to various biases. In this study, we observed non‐verbal behaviour of 47 long‐term romantic heterosexual couples during their interview with a female experimenter, whom the women in the couples may have perceived as a potential rival. We measured non‐verbal displays of mate retention tactics (direct guarding, intimacy inducement, appearance enhancement, and love and care display), as well as relationship maintenance strategies of openness and positivity. We expected that relationship quality as reported by both partners in the couple would be positively associated with ‘benefit‐provisioning’ mate retention behaviours and negatively associated with a ‘cost‐inflicting’ mate retention tactic (direct guarding). Relationship quality was assessed by Spanier's Dyadic Adjustment Scale using both the total score of dyadic adjustment and a Dyadic Satisfaction subscale. We found a significant association between both partners' dyadic adjustment and satisfaction and woman's appearance enhancement behaviours (such as self‐touch, hair flip and primp) in the presence of her partner and a potential rival. We also found a negative association between partner's dyadic adjustment and woman's direct guarding of partner using short looks, and a positive association between woman's intimacy‐inducing behaviour using long gaze and her own dyadic satisfaction and her partner's dyadic adjustment. Our results highlight the specific role of female attractiveness in later stages of romantic relationships within the context of mate retention and draw attention to the significance of the use of observational techniques in addition to self‐reports.     

Does the Spanish version of the SWLS measure the same in Spain and Peru?

AimSatisfaction with life is a measure of protection in older adults. There lies the importance of providing quality instruments. The aim of the study was to evaluate the invariance of the life satisfaction scale (SWLS) in two samples of older adults in Spain and Peru.MethodThe participants were 857 older adults in Spain (mean age = 68.23 years, SD = 5.93) and 336 older adults in Peru (average age = 72.42, SD = 7.07). All multi-group confirmatory factor analyzes were estimated in Mplus 8.0.ResultsThe results indicate the presence of a strict invariance of the one-dimensional structure of the SWLS in samples of older adults in Spain and Peru, which allows for meaningful comparisons of latent means and covariances. Comparison of latent means showed small differences in the construct between the cultural groups.ConclusionsThe SWLS is a valid instrument for intercultural comparisons between Spanish and Peruvian population. The measurement invariance assessment contributes to a better understanding of life satisfaction in populations from different cultural contexts.     

Spatial models of political competition with endogenous political parties

Two important human action selection processes are the choice by citizens of parties to support in elections and the choice by party leaders of policy 'packages' offered to citizens in order to attract this support. Having reviewed approaches analysing these choices and the reasons for doing this using the methodology of agent-based modelling, we extend a recent agent-based model of party competition to treat the number and identity of political parties as an output of, rather than an input to, the process of party competition. Party birth is modelled as an endogenous change of agent type from citizen to party leader, which requires describing citizen dissatisfaction with the history of the system. Endogenous birth and death of parties transforms into a dynamic system even in an environment where all agents have otherwise non-responsive adaptive rules. A key parameter is the survival threshold, with lower thresholds leaving citizens on average less dissatisfied. Paradoxically, the adaptive rule most successful for party leaders in winning votes makes citizens on average less happy than under other policy-selection rules.