全英文“环境工程微生物学”的国家线下一流本科课程成长之路

国家一流本科课程的评审认定是教育部全面深化教育教学改革的重要举措,也是提升本科教学质量的重要一环,极大地促进了任课教师对标评价量规进行教研教改。为促进环境工程专业核心基础课的教改,“环境工程微生物学”全英课程组在先进的教育思想、方法和教育心理学的指导下,对教学理念、课程内容、教学组织和实施等多方面进行了大胆的改革和创新,注重课程思政和因材施教,增加课堂教学的师生互动和生生互动;针对工科类学生的培养目标,引入实际工程的应用案例,在课内外补充环境微生物工程领域研究的最新进展和教师的科研成果,注重提升课程的高阶性、创新性和挑战度,从多方面强化知识、能力、素质的有机融合,学生学习效果明显提高。申报并获认定为首批国家线下一流本科课程和广东省一流本科课程。     

Social modulation of testosterone levels in male black howlers (Alouatta pigra)

The influence of social factors on the modulation of male testosterone levels has been demonstrated among several vertebrate species. In addition to sexual activity, parental care and reproductive competition affect testosterone secretion. We examined variations in testosterone levels among male black howlers (Alouatta pigra) in various social contexts. Fecal samples were collected from nine males living in five different groups in the Mexican state of Campeche. The potential for intragroup and extragroup competition varied among the groups. The number of resident males living in the groups was the only variable that significantly explained variations in testosterone levels. Males living in unimale groups had higher testosterone levels; the highest testosterone levels were recorded for males that had experienced a shift from multimale to unimale group compositions. In this species, the probability of being challenged by extragroup males and evicted from the group during immigration events increases when males live in unimale groups. Therefore, our results suggest that male black howlers respond to competition for group membership by increasing their testosterone levels. In this context, testosterone secretion represents an anticipatory response to reproductive conflicts. Therefore, although males living in unimale groups have exclusive access to females, they face higher physiological costs associated with sustaining high testosterone levels for extended time periods.     

肿瘤干细胞研究面临的挑战与对策

肿瘤干细胞（TSC）学说已吸引更多学者对其予以关注与研究。在TSC研究取得较快进展的同时,也遇到了许多困难与挑战。从全面认识TSC生物学特性、建立特异性鉴定TSC的方法和靶向治疗TSC等3个方面提出应对策略,旨在为TSC研究领域有重大突破而抛砖引玉。     

Overcoming translational challenges – The delivery of mechanical stimuli in vivo

Despite major medical advances, non-union bone fractures and skeletal defects continue to place significant burden on the patient, the clinicians and the healthcare system as a whole. Current bone substitute approaches are still limited in effectiveness and to date no adequate bone substitute material has been developed for routine clinical application. Tissue engineering presents a novel approach to tackling this clinical burden and developing an acceptable solution for the treatment of skeletal defects. Over the past three decades the field has evolved to appreciate the key biological, material and physical parameters influencing the development of a cell-based tissue engineered therapy and to create associated technologies to exploit such parameters. In recent years a number of therapies have started progressing along the pre-clinical pipeline to build a case for regulatory approval and ultimately clinical adoption. However, little emphasis has been given to the translational challenges faced when moving from “bench-to-bedside”. One particular challenge lies in the delivery of functional mechanical stimuli to implanted cell populations to activate and promote osteogenic activities. This review introduces novel bio-magnetic approaches to overcoming this challenge.     

应对全球气候变化的昆虫学研究

大气二氧化碳浓度升高、温度上升、降雨分布不均、灾害性天气出现频次增加等全球气候变化,深刻改变着农林生态系统昆虫群落的组成结构、功能和演替,使昆虫分布区域扩大、发生世代增多、生态适应性变异,从而影响了原有的植物-害虫-天敌间内在联系和各营养层间的固有平衡格局,最终导致一些害虫暴发成灾,一些昆虫种群数量下降,甚至一些昆虫物...