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基于氨基酸特征序列对人类Rh血型系统的蛋白质结构分析   总被引:1,自引:0,他引:1  
高雷  朱平 《生物信息学》2009,7(4):248-251
利用代数学中同态思想和物理中的“粗粒化”思想,以及HP模型,根据a,t,c,g的化学结构分类,提出了DNA序列的特征序列概念(σ-,τ-,σ∩τ-)并推广到蛋白质序列中,从而给出一种数值刻划,将蛋白质序列简化成一个(0,1)序列,基于上述给出特征序列的方法,根据氨基酸分子量与简并度的关系,提出了另外一种DNA序列的特征序列概念(-)并推广到蛋白质序列中,进而给出了另外一种数值刻划,将蛋白质序列简化成一个(0,1,2)序列,通过比较RHD基因和RHCE基因的特征序列的数值刻划图,得出RHD基因和RHCE基因均偏爱使用低分子量且高简并度的氨基酸。  相似文献
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Aim of the study: Pain perception is associated with different phenotypic characteristics such as sex, eye, and hair color. Hence, it is assumed that ABO blood type can also affect pain perception.

Materials and methods: In order to investigate this hypothesis, an experimental study with healthy volunteers (18–40 years) was designed. The experimental procedure included a blood type test and two rounds of pressure pain threshold assessments separated by a cold pressor test. Pressure pain threshold was assessed bilaterally at the temporalis, masseter, and deltoid muscles, where the muscle sites were randomized. Cold pressor test was conducted by immersion of participants’ non-dominant hand into iced water of 1–4 °C for 2 min.

Results: Thirty-seven healthy volunteers, distributed in the four blood type groups, completed the study. Participants with blood type B scored the highest pressure pain thresholds at the examined craniofacial muscles, while participants with blood type AB tended to score the lowest. Furthermore, participants with blood type AB displayed the highest elevation in pressure pain thresholds after cold pressor test.

Conclusions: Participants with blood type B displayed the lowest mechanical pain sensitivity and the blood type AB group exhibited the strongest conditioned pain modulation effect. These findings emphasize the necessity of considering ABO blood types in future pain research.  相似文献

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