排序方式: 共有40条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
Ohhata T Tachibana M Tada M Tada T Sasaki H Shinkai Y Sado T 《Genesis (New York, N.Y. : 2000)》2004,40(3):151-156
One of the two X chromosomes becomes inactivated during early development of female mammals. Recent studies demonstrate that the inactive X chromosome is rich in histone H3 methylated at Lys-9 and Lys-27, suggesting an important role for these modifications in X-inactivation. It has been shown that in the mouse Eed is required for maintenance of X-inactivation in the extraembryonic lineages. Interestingly, Eed associates with Ezh2 to form a complex possessing histone methyltransferase activity predominantly for H3 Lys-27. We previously showed that G9a is one of the histone methyltransferases specific for H3 Lys-9 and is essential for embryonic development. Here we examined X-inactivation in mouse embryos deficient for G9a. Expression of Xist, which is crucial for the initiation of X-inactivation, was properly regulated and the inactivated X chromosome was stably maintained even in the absence of G9a. These results demonstrate that G9a is not essential for X-inactivation. 相似文献
5.
Neil Brockdorff 《RNA (New York, N.Y.)》2013,19(4):429-442
6.
7.
8.
9.
10.