洛铂与顺铂联合吉西他滨用于晚期肺癌患者化疗的疗效比较

目的:研究洛铂与顺铂联合吉西他滨用于晚期肺癌患者化疗的临床疗效,为临床治疗提供依据。方法:选取2013年1月到2015年1月我院收治的晚期肺癌患者190例,按照随机数字表法将患者分为I组和II组,每组95例,I组给予洛铂联合吉西他滨治疗,II组给予顺铂联合吉西他滨治疗,应用欧洲癌症研究和治疗组织(EORTC)的生命质量测定量表(QLQ-C30)评价治疗前、后患者的生活质量,比较两组近期疗效、远期疗效以及不良反应。结果:两组近期疗效比较无统计学意义(P0.05);I组平均缓解期(6.33±1.82)月显著长于II组的(5.13±0.84)月,I组中位生存期为(9.95±2.31)月显著长于II组的(7.82±1.24)月,比较差异均有统计学意义(P0.05);治疗后两组QLQ-C30评分均显著提高,且I组高于II组,比较差异具有统计学意义(P0.05);I组骨髓抑制发生率显著高于II组,恶心、呕吐发生率显著低于II组,比较差异具有统计学意义(P0.05)。结论:洛铂与顺铂联合吉西他滨用于晚期肺癌患者化疗近期疗效相当,洛铂联合吉西他滨具有较好远期疗效,且能提高患者生活质量,但骨髓抑制发生率较高。     

洛铂与紫杉醇联合治疗晚期卵巢癌的临床观察

目的：观察洛铂与紫杉醇联合化疗治疗晚期卵巢癌的近期疗效及不良反应。方法：50例晚期卵巢癌（Ⅲ期或Ⅳ期）患者,其中26例患者采用洛铂＋紫杉醇静脉化疗,其中洛铂30mg／m2,d1天,紫杉醇135～175mg／m。dl天。24例患者采用顺铂＋紫杉醇静脉化疗,其中顺铂25mg／m2,d1-3天,紫杉醇135～175mg／m。dl天,2～4个疗程观察疗效。结果：26例洛铂组患者中,完全缓解7例,部分缓解8例,稳定9例,进展2例,有效率为57．7％。24例顺铂组患者中,完全缓解5例,部分缓解8例,稳定6例,进展5例,有效率为54．2％。主要毒副反应为骨髓抑制、骨骼酸痛、神经毒性和脱发。结论：洛铂联合紫杉醇治疗晚期卵巢癌疗效较好,毒副反应可以耐受。     

Lobaplatin-based regimens outperform cisplatin for metastatic breast cancer after anthracyclines and taxanes treatment

The goal of this study was to assess the antitumor efficacy and safety of lobaplatin-based regimens as the second line of treatment in patients with metastatic breast cancer (MBC) resistant to anthracyclines and taxanes, compared with that of cisplatin-based regimens. During August 2012 to April 2015, 87 patients who received lobaplatin-based regimens or cisplatin-based regimens were included. Medical records of the patients noted that lobaplatin (30?mg/m²) or cisplatin (25?mg/m²), combined with another chemotherapeutic agent such as Gemcitabine (1000?mg/m²) or Vinorelbine (25?mg/m²), was intravenously given to the patients on a basis of twenty-one days as one treatment cycle. All the patients were followed until August 2017. The endpoint of this study was progression-free survival (PFS), overall survival (OS), and estimated objective response rate (RR). Safety and drug tolerability data were also obtained. Lobaplatin-based regimens prolonged PFS compared to cisplatin-based regimens (median 13.2 vs 4.7?months, hazard ratio?=?0.37, 95% confidence intervals: 0.21–0.67, P?=?.0007), while OS was not significantly different between the two groups (hazard ratio?=?0.72, 95% confidence intervals: 0.40–1.30, P?=?.2767), as was objective RR (37.8% vs 33.4%, $x^2$ = 0.19, P?=?.6653). Nausea/vomiting and renal injury were more frequent with cisplatin-based regimens. Our results show that lobaplatin-based regimens are superior to cisplatin in terms of efficacy and are better tolerated.     

多柔比星脂质体单药和联合洛铂方案治疗复发卵巢癌的临床研究

目的:评价盐酸多柔比星脂质体单药(PLD)与盐酸多柔比星脂质体联合洛铂治疗复发性卵巢癌的安全性和临床疗效。方法:收集2012年4月至2015年10月我科收治的31例复发晚期上皮性卵巢癌患者,根据患者是否存在铂类耐药分为多柔比星组(单药组)15例及多柔比星+洛铂组(对照组)16例。单药组给盐酸多柔比星脂质体50 mg/m~2,静滴;对照组给盐酸多柔比星脂质体20-30 mg/m~2,洛铂30-50 mg/m~2,静脉滴注,两组每21-28天重复一次,观察和比较两组的临床疗效和毒性反应的发生情况。结果:所有患者完成3-8周期,客观有效率(ORR)为38.7%。单药组为33.3%,对照组为占43.8%,两组ORR比较差异无统计学意义(P=0.411)。单药组骨髓抑制的毒副作用较对照组发生率显著升高高(P=0.019),两组其他毒副反应的发生情况比较差异无统计学意义(P0.05)。单药组和对照组中位生存时间(MST)分别为10个月(95%CI:1.242-18.758)、18个月(95%CI:8.261-27.739),中位无进展生存期(PFS)分别为7个月(95%CI:2.210-13.797)、13个月(95%CI:4.368-21.632),两组MST、PFS比较差异均无统计学意义(P0.277)。结论:聚乙二醇脂质体阿霉素单体或聚乙二醇脂质体阿霉素联合洛铂治疗复发性卵巢癌的疗效相当,而聚乙二醇脂质体阿霉素单体的安全性更高。     

重组人血管内皮抑制素注射液联合洛铂对恶性胸腔积液患者生活质量及免疫功能的影响

目的:探讨重组人血管内皮抑制素注射液联合洛铂对恶性胸腔积液患者生活质量及免疫功能的影响。方法:选择2015年3月至2017年3月期间我院收治的恶性胸腔积液患者56例为研究对象,按照不同的治疗方式分为研究组(n=28)和对照组(n=28)。对照组给予洛铂治疗,研究组给予重组人血管内皮抑制素注射液联合洛铂治疗。比较两组患者治疗前后生活质量变化、免疫功能变化、临床疗效和不良反应发生情况。结果:研究组患者生活质量改善率高于对照组(P0.05)。治疗前,两组免疫功能指标含量经统计分析差异无统计学意义(P0.05),与治疗前比较,两组治疗后4周CD3~+、CD4~+、CD4~+/CD8~+、NK含量均升高,CD8+含量降低,且研究组CD3~+、CD4~+、CD4~+/CD8~+、NK含量较对照组升高,CD8~+含量较对照组降低(P0.05)。研究组总有效率为78.57%,与对照组的46.43%比较差异有统计学意义(P0.05)。两组患者心脏反应、呕吐、恶心、血小板减少、白细胞减少、贫血、乏力发生率比较差异均无统计学意义(P0.05)。结论:重组人血管内皮抑制素注射液联合洛铂治疗恶性胸腔积液具有较好的疗效,其可以改善患者生活质量,提高免疫功能,且不会增加患者不良反应,值得临床推广。