排序方式: 共有47条查询结果,搜索用时 159 毫秒
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目的:建立肾衰康浓缩丸质量控制方法。方法:采用TLC鉴别肾衰康浓缩丸中大黄、丹参;采用HPLC-ELSD对制剂中黄芪甲苷进行含量测定,流动相为乙腈-水(30:70),流速:1 mL/min,柱温:28℃,漂移管温度:42℃,氮气:355kPa。结果:大黄、丹参的TLC鉴别斑点清晰、专属性强;黄芪甲苷在1.0μg-10.0μg之间呈良好的线性关系(r=0.9997,n=5),平均回收率为99.81%,RSD为1.73%(n=6)。结论:所建立的方法简便准确、专属性强、重现性好,可作为控制肾衰康浓缩丸质量的方法。 相似文献
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目的:探讨地黄饮子对小鼠抗体激发水平的影响。方法:将40只经卵核蛋白免疫过的小鼠随机分A、B两组,分别灌服地黄饮子和葡萄糖,1次/d,每次0.5mL只,连续7d后,加强免疫,再经7d,用ELISA法检测血清中相应抗体生成水平。结果:与葡萄糖组比较,地黄饮子组小鼠抗体水平升高,差异有显著性意义(P<0.05)。结论:地黄饮子有可能促进小鼠抗体激发水平和免疫水平的提高。 相似文献
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滋补肾阴方与温补肾阳方对卵巢切除所致骨质疏松大鼠治疗作用的对比研究 总被引:4,自引:1,他引:3
目的 对比观察滋补肾阴方与温补肾阳方对卵巢切除所致骨质疏松大鼠的治疗作用 ,以探讨它们之间的疗效是否存在差异。方法 将雌性Wistar大鼠 4 9只随机分为正常对照组、假手术组、卵巢切除组、滋阴组 (灌服生药含量为 1 0 5g ml的滋补肾阴方 ,按每 10 0g体重 0 7ml剂量 )、补阳组 (灌服生药含量为 0 78g ml的温补肾阳方 ,按每 10 0g体重 0 7ml剂量 )。于造模 3个月后开始给药 ,1次 日 ,连续 6d ,休息一天后 ,再连续灌服 6d。给药 2个月后 ,将大鼠处死 ,取胫骨行不脱钙骨切片 ,甲苯胺蓝染色 ,对其进行骨组织形态计量。结果 切除卵巢 5个月后 ,大鼠胫骨TBV %显著降低 ,TRS %以及TFS %、AFS %、MAR、BFR、OSW和mAR皆显著增高 ,给大鼠灌服滋阴补肾方和温补肾阳方 2个月后 ,均能使上述指标发生逆转 ,但程度有所不同 ,温补肾阳方的效果要明显优于滋补肾阴方。结论 滋补肾阴方与温补肾阳方对卵巢切除所致的骨质疏松均有明显的治疗作用 ,但温补肾阳方的疗效要优于滋阴补肾方。 相似文献
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摘要 目的:探讨六味地黄丸联合小剂量雌孕激素替代疗法对围绝经期综合征(PMS)患者性激素、骨密度和血脂的影响。方法:研究对象选取2018年12月~2020年5月期间我院接收的PMS患者93例,根据乱数表法将患者随机分为对照组(n=46)和研究组(n=47),对照组给予小剂量雌孕激素替代疗法,研究组给予六味地黄丸联合小剂量雌孕激素替代疗法,28d为一个治疗周期,对比两组患者治疗3个周期后的疗效、性激素、腰椎L2~L4骨密度、血脂、子宫内膜厚度及不良反应。结果:治疗3个周期后,研究组的总有效率为91.49%(43/47),高于对照组的76.09%(35/46)(P<0.05)。治疗3个周期后,研究组改良Kupperman评分表(KMI)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、促卵泡刺激素(FSH)、促黄体生成素(LH)低于对照组,高密度脂蛋白胆固醇(HDL-C)、子宫内膜厚度、腰椎L2~L4骨密度、雌二醇(E2)高于对照组(P<0.05)。两组不良反应总发生率对比差异无统计学意义(P>0.05)。结论:六味地黄丸联合小剂量雌孕激素替代疗法治疗PMS患者,可有效缓解临床症状,提高骨密度,改善PMS患者的性激素及血脂水平,疗效确切。 相似文献
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Cui Liu Qian He Linlin Zeng Ling Shen Qiaomei Luo Wentao Zhang Xia Zhou Jun Wan 《化学与生物多样性》2021,18(12):e2100705
Emerging evidence suggests that a high-fat diet (HFD) can influence endoplasmic reticulum (ER) stress and gut microbiota. Crataegi Fructus is a traditional Chinese herb widely used in formulas for dyspepsia, with Dashanzha Pill composed of raw Crataegi Fructus (DR) being a representative drug. Processing products of Crataegi Fructus, however, have a stronger pro-digestive effect, and we hypothesized that Dashanzha Pill composed of charred Crataegi Fructus (DC) is more effective. We found that the contents of glucose 1-phosphate and luteolin in DR and DC were substantially different via ultra-high performance liquid chromatography-hybrid quadrupole-Orbitrap high-resolution mass spectrometry. DC outperformed DR in improving histopathological changes, increasing gastrin and motilin, and decreasing vasoactive intestinal peptides in rats with HFD induced dyspepsia. Fecal microbiota analysis revealed that DC could restore the disturbed intestinal microbiota composition, including that of Bacteroides, Akkermansia, and Intestinimonas to normal levels. Furthermore, DC significantly reduced the mRNA and protein levels of glucose-regulated protein 78, protein kinase R-like ER kinase, and eukaryotic initiation factor 2α. Taken together, DC outperformed DR in relieving dyspepsia by regulating gut microbiota and alleviating ER stress. 相似文献
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Khalid Mahmood Zia Mohammad ZuberAli Rizwan Tahir JamilShazia Tabasum Muhammad Shahid 《Carbohydrate polymers》2012,87(3):2063-2067
A series of poly(vinyl alcohol) of different commercial grades were prepared and applied onto the surfaces of cotton and blends of cotton/polyester fibers. The molecular structure was confirmed using Fourier Transform Infrared spectroscopy. Physicochemical properties such as viscosity and solid contents (%) were determined and discussed. Factors affecting the performance properties of the finished substrate such as post-treatment with poly(vinyl alcohol) of different grades, concentration and dilutions were studied. Fixation of the poly(vinyl alcohol) onto/or within the cellulose structure is accompanied by the formation of semi-inter-penetrated network structure thereby enhancing the association as well as providing very high stiffness. The results revealed that applications of poly(vinyl alcohol) on the textile fabrics in the finishing processes enables to enhance the stiffness as well as helps to improve its pilling resistance. 相似文献
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目的:探讨通脉养心丸对冠状动脉粥样硬化性心脏病(CAD)伴慢性病贫血(ACD)患者铁调素水平的影响。方法:于2015年4月-2016年6月在上海交通大学医学院附属仁济医院(南院)接受治疗的患者中选取70例年龄≥40岁的冠状动脉粥样硬化性心脏病伴慢性病贫血患者并随机分成两组,每组各35人,分别服用通脉养心丸(II组)或未服用通脉养心丸(III组)。同时选取冠心病患者不伴有慢性病贫血40人为对照组(I组),该组患者服用通脉养心丸。观察比较三组服药8周前后的血铁调素及血红蛋白、铁蛋白水平的变化。结果:服药前,II、III组的血Hepc水平均明显高于I组(P0.05)。8周治疗后,II组患者血Hepc表达明显下降,Hb水平较治疗前显著升高(P0.05),其余两组血Hepc表达与治疗前相比差异无统计学意义(P0.05);II组、III组血Hepc水平显著高于I组(P0.05),III组的血Hepc水平显著高于II组;III组患者的Hb水平明显低于I组、II组(P0.05)。结论:通脉养心丸能降低冠状动脉粥样硬化性心脏病伴慢性病贫血患者的铁调素水平,提高该类患者的血红蛋白值,对冠状动脉粥样硬化性心脏病伴慢性病贫血患者,尤其是轻度贫血患者有一定的治疗价值。 相似文献