全文获取类型
收费全文 | 13396篇 |
免费 | 1310篇 |
国内免费 | 688篇 |
出版年
2024年 | 26篇 |
2023年 | 350篇 |
2022年 | 326篇 |
2021年 | 697篇 |
2020年 | 783篇 |
2019年 | 1026篇 |
2018年 | 756篇 |
2017年 | 458篇 |
2016年 | 531篇 |
2015年 | 678篇 |
2014年 | 938篇 |
2013年 | 1123篇 |
2012年 | 663篇 |
2011年 | 803篇 |
2010年 | 543篇 |
2009年 | 646篇 |
2008年 | 635篇 |
2007年 | 624篇 |
2006年 | 568篇 |
2005年 | 492篇 |
2004年 | 432篇 |
2003年 | 400篇 |
2002年 | 322篇 |
2001年 | 165篇 |
2000年 | 147篇 |
1999年 | 131篇 |
1998年 | 110篇 |
1997年 | 77篇 |
1996年 | 90篇 |
1995年 | 81篇 |
1994年 | 64篇 |
1993年 | 70篇 |
1992年 | 59篇 |
1991年 | 47篇 |
1990年 | 41篇 |
1989年 | 33篇 |
1988年 | 38篇 |
1987年 | 34篇 |
1986年 | 40篇 |
1985年 | 41篇 |
1984年 | 68篇 |
1983年 | 41篇 |
1982年 | 54篇 |
1981年 | 35篇 |
1980年 | 29篇 |
1979年 | 21篇 |
1978年 | 13篇 |
1977年 | 12篇 |
1976年 | 9篇 |
1974年 | 6篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Mutual information and entropy transfer analysis employed on two inactive states of human beta-2 adrenergic receptor (β2-AR) unraveled distinct communication pathways. Previously, a so-called “highly” inactive state of the receptor was observed during 1.5 microsecond long molecular dynamics simulation where the largest intracellular loop (ICL3) was swiftly packed onto the G-protein binding cavity, becoming entirely inaccessible. Mutual information quantifying the degree of correspondence between backbone-Cα fluctuations was mostly shared between intra- and extra-cellular loop regions in the original inactive state, but shifted to entirely different regions in this latest inactive state. Interestingly, the largest amount of mutual information was always shared among the mobile regions. Irrespective of the conformational state, polar residues always contributed more to mutual information than hydrophobic residues, and also the number of polar-polar residue pairs shared the highest degree of mutual information compared to those incorporating hydrophobic residues. Entropy transfer, quantifying the correspondence between backbone-Cα fluctuations at different timesteps, revealed a distinctive pathway directed from the extracellular site toward intracellular portions in this recently exposed inactive state for which the direction of information flow was the reverse of that observed in the original inactive state where the mobile ICL3 and its intracellular surroundings drove the future fluctuations of extracellular regions. 相似文献
2.
3.
This article is part of a Special Issue Energy Balance. 相似文献
4.
5.
《Bioorganic & medicinal chemistry letters》2014,24(13):2949-2953
The G protein-coupled receptor 40 (GPR40) mediates enhancement of glucose-stimulated insulin secretion in pancreatic β cells. The GPR40 agonist has been attracting attention as a novel insulin secretagogue with glucose dependency for the treatment of type 2 diabetes. The optimization study of compound 1 led to a potent and bioavailable GPR40 agonist 24, which showed insulin secretion and glucose lowering effects in rat OGTT. Compound 24 is a potential lead compound for a novel insulin secretagogue with a low risk of hypoglycemia. 相似文献
6.
7.
8.
9.
《Current biology : CB》2020,30(11):2166-2174.e3
10.
The NADPH-dependent reduction of some photosynthetic electron carriers in the dark, and the reduction of NADP+ associated
with the glycolytic sequence and the oxidative pentose phosphate pathway in chloroplasts are reviewed. The postulated pathways
of electron transports sensitive and insensitive to antimycin A are also evaluated. It is proposed that the electron flow,
predominantly through cytochrome bf complex, may be also involved in the pathway of NADPH-dependent and antimycin A-insensitive back electron transport. An information
on the chlororespiration in higher plants is also included.
This revised version was published online in June 2006 with corrections to the Cover Date. 相似文献