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1.
The ability of a number of nitrogen-containing compounds that simultaneously carry the adamantane and monoterpene moieties to inhibit Tdp1, an important enzyme of the DNA repair system, is studied. Inhibition of this enzyme has the potential to overcome chemotherapeutic resistance of some tumor types. Compound (+)-3c synthesized from 1-aminoadamantane and (+)-myrtenal, and compound 4a produced from 2-aminoadamantane and citronellal were found to be most potent as they inhibited Tdp1 with IC50 values of 6 and 3.5 µM, respectively. These compounds proved to have low cytotoxicity in colon HCT-116 and lung A-549 human tumor cell lines (CC50 > 50 µM). It was demonstrated that compound 4a at 10 µM enhanced cytotoxicity of topotecan, a topoisomerase 1 poison in clinical use, against HCT-116 more than fivefold and to a lesser extent of 1.5 increase in potency for A-549. 相似文献
2.
1. Modification of behaviours in the presence of predators or predation cues is widespread among animals. The costs of a behavioural change in the presence of predators or predation cues depend on fitness effects of lost feeding opportunities and, especially when organisms are sexually dimorphic in size or timing of maturation, these costs are expected to differ between the sexes. 2. Larval Aedes triseriatus (Say) (Diptera: Culicidae) were used to test the hypothesis that behavioural responses of the sexes to predation cues have been selected differently due to different energy demands. 3. Even in the absence of water‐borne predation cues, hungry females (the larger sex) spent more time browsing than did males, indicating a difference in energy needs. 4. In the presence of predation cues, well‐fed larvae of both sexes reduced their activity more than did hungry larvae, and males shifted away from high‐risk behaviours to a greater degree than did females, providing the first evidence of sex‐specific antipredator behaviour in foraging mosquito larvae. 5. Because sexual size dimorphism is common across taxa, and energetic demands are probably correlated with size dimorphism, this research demonstrates the importance of investigating sex‐specific behaviour and behavioural responses to enemies, and cautions against generalising results between sexes. 相似文献
3.
In many parts of the world, wildlife species congregate at ‘hotspot’ locations that offer feeding opportunities unmatched in the wider landscape. But to exploit those resource‐rich sites, animals must first locate them. In tropical Australia, predators and scavengers (especially dingos, scrub turkeys, snakes, and invasive toads) gather beneath large canopy‐emergent trees that house breeding colonies of metallic starlings (Aplonis metallica). Some wildlife species feed on fallen nestlings whereas others consume the rich insect fauna supported by bird detritus, or the other species attracted to those resources. Those congregations largely cease as soon as colony trees fall, suggesting that wildlife aggregations are responses to bird‐associated cues rather than to specific locations. To identify the proximate cues that elicit congregation of wildlife under such trees, we deployed sound cues (starling‐chatter) and two types of scent cues (soil from beneath a starling tree, and complete nests on broken branches). We recorded visitations by animals with camera‐traps. Starling‐chatter did not attract significant numbers of animals, but soil from beneath colony trees attracted many animals (mostly scrub turkeys). Complete nests attracted nest‐predators (dingos, snakes). Our experiments suggest that faunal aggregations beneath colony trees are driven by proximate responses to distinctive scent cues in the soil, especially for species that obtain their food from that bird‐fertilized substrate; but predators that feed directly on fallen nestlings key in specifically on that resource. 相似文献
4.
A. R. Liboff 《Electromagnetic biology and medicine》2017,36(2):177-181
It has been established that living things are sensitive to extremely low-frequency magnetic fields at vanishingly small intensities, on the order of tens of nT. We hypothesize, as a consequence of this sensitivity, that some fraction of an individual’s central nervous system activity can be magnetically detected by nearby individuals. Even if we restrict the information content of such processes to merely simple magnetic cues that are unconsciously received by individuals undergoing close-knit continuing exposure to these cues, it is likely that they will tend to associate these cues with the transmitting individual, no less than would occur if such signals were visual or auditory. Furthermore, following what happens when one experiences prolonged exposure to visual and like sensory inputs, it can be anticipated that such association occurring magnetically will eventually also enable the receiving individual to bond to the transmitting individual. One can readily extrapolate from single individuals to groups, finding reasonable explanations for group behavior in a number of social situations, including those occurring in families, animal packs, gatherings as found in concerts, movie theaters and sports arenas, riots and selected predatory/prey situations. The argument developed here not only is consistent with the notion of a magnetic sense in humans, but also provides a new approach to electromagnetic hypersensitivity, suggesting that it may simply result from sensory overload. 相似文献
5.
The phytochemical study of the roots of Scorzonera divaricata Turcz led to the isolation of 27 compounds, including eight sterols (1–8), one lignan (9), two cumarins (10, 11), five phenylpropanoids (12–16), six benzene derivatives (17–22), methyl-β-D-fructofuranoside (23), monolinolein (24), and three aliphatic acids (25–27). The structures of isolated compounds were identified using NMR and ESI-MS spectroscopic methods and comparing them with those previously reported. Except for β-daucosterol (8), scopoletin (10) and caffeic acid (16) from S. divaricata, this is the first report of the other 24 compounds from S. divaricata. Among them, eleven compounds (2–6, 11, 17, 19, 20, 23, 25) were reported from genus Scorzonera for first time, suggesting that they could be used to distinguish S. divaricata from the other species of Scorzonera. Furthermore, the chemotaxonomic significance of isolated compounds from S. divaricata has also been discussed. 相似文献
6.
Douglas P. Chivers Xiaoxia Zhao Grant E. Brown Tracy A. Marchant Maud C. O. Ferrari 《Evolutionary ecology》2008,22(4):561-574
In a series of experiments, we investigated the effects of food availability and risk frequency on the dynamics of predator-induced
changes in growth and morphology of prey fish using goldfish (Carassius auratus) as our test species. In experiment 1, we fed goldfish high or low food rations and exposed them to either alarm cues from
conspecifics, cues from swordtails or a water control. After 60 days, goldfish in the alarm cue treatment significantly increased
their body depth and body weight but had smaller body length than goldfish exposed to swordtails cues or water, likely reducing
their vulnerability to gape-limited predators. Importantly, food level had an impact on the amplitude of the morphological
changes. In experiment 2, goldfish were exposed to two different frequencies of predation cues or a water control for 50 days.
The cues were either continued or discontinued from day 51 to 100, and all cues were resumed from day 101 to 150. We found
that goldfish exposed to predation cues increased their depth and weight at a faster rate than did the goldfish exposed to
water, and of particular significance was the fact that frequency of risk had an effect on the amplitude of the change. When
the cues were interrupted, the increase in growth rate parameters was reduced to the level of the goldfish exposed to water.
However, when the cues were resumed, the rate increased to match the growth rate of the goldfish that were continuously exposed
to the cues. Finally, we staged encounters between goldfish of differing morphologies and yellow perch (Perca flavescens) and found that deep-bodied goldfish had better survival than the shallow-bodied ones. These experiments illustrate the dynamic
nature of inducible morphological defences. 相似文献
7.
Most models to account for variation in defensive chemical production in plants assume that defensive chemical production is a quantitative trait determined by the additive effects of many genes, and that defensive chemical production is genetically negatively correlated with fitness. The inheritance of quantities of geranylflavanones and seed production, an estimate of female fitness, was studied in reciprocal crosses between several chemically distinct populations of Mimulus aurantiacus to test those assumptions. Genetic analyses using reciprocal crosses were used to test for maternal or paternal genetic effects. The quantities of individual geranylflavanones of the hybrids generally were inherited with dominance or over-dominance. Reciprocal genetic effects were rarely found. Within populations, leaf resin production in M. aurantiacus was independent of seed production. Results are consistent with previous reports suggesting that any evolutionary change in geranylflavanone production within populations may be constrained by low levels of genetic variation in geranylflavanone production. 相似文献
8.
中国蓼科植物化学成分研究进展 总被引:5,自引:0,他引:5
我国有蓼科植物13属约235种,37变种.通过对已报道的蓼科植物的化学成分综述分析,表明:大黄属、何首乌属、虎杖属与酸模属都含有蒽醌类化合物(如大黄素、大黄酸、大黄酚等);而养麦属与蓼属富含黄酮类化合物,极少有蒽醌类存在.蓼科植物化学成分主要为蒽醌类和黄酮类,鞣质在该科中普遍存在;生物碱很少、有些属还含有芪类. 相似文献
9.
Michael Arvedlund Akihiro Takemura 《Journal of experimental marine biology and ecology》2006,338(1):112-122
A commercially important coral-reef fish, the spangled emperor Lethrinus nebulosus, settles into seagrass beds at the end of its pelagic larval phase, but the mechanism for locating these beds is unknown. To investigate this mechanism we first used a wide-choice, ex situ setup to examine the ability of captivity-reared naïve L. nebulosus settlers to select their first benthic habitat by reference to chemical cues. Second, we examined the morphology and ultrastructure of the nasal olfactory organ in settling L. nebulosus juveniles. We obtained the first evidence of a tropical seagrass-settling coral reef fish that can use chemical environmental cues in selecting its first benthic habitat at ranges up to at least 2 m. The L. nebulosus settlers exhibited a well developed pair of nasal olfactory organs, positioned in nares on the dorsal side of the head. These organs were elliptical radial rosettes, one in each of the olfactory chambers, and each comprised 12 lamellae, six on each side of a midline raphe, which were totally covered with sensory and non-sensory cilia, except for the margins. This type of cilia distribution is thought to indicate an acute sense of smell. The olfactory epithelium contained mature and immature ciliated receptor neurons bearing three to five cilia, and a second type of receptor neuron bearing six to eight microvilli. 相似文献
10.