Genetic associations with coronary heart disease: Meta-analyses of 12 candidate genetic variants

Aims

The aim of this study was to evaluate the combined contribution of 12 genetic variants to the risk of coronary heart disease (CHD).

Methods

Through a comprehensive literature search for genetic variants involved in the CHD association study, we harvested a total of 10 genes (12 variants) for the current meta-analyses. These genes consisted of GPX1 (rs1050450), PPARD (rs2016520), ALOX15 (rs34210653), SELPLG (rs2228315), FCGR2A (rs1801274), CCL5 (rs2107538), CYP1A1 (rs4646903), TP53 (rs1042522), CX37 (rs1764391), and PECAM1 (rs668, rs12953, and rs1131012).

Results

A total of 45 studies among 23,314 cases and 28,430 controls were retrieved for the meta-analyses of 12 genetic variants. The results showed a significant association between the GPX1 rs1050450 polymorphism and CHD (odd ratio (OR) = 1.61, 95% confidence interval (CI) = 1.25–2.07, P = 0.0002). Other meta-analyses of the rest 11 variants suggested a lack of association with the risk of CHD.

Conclusion

Our results confirmed that GPX1 rs1050450 was associated with susceptibility to CHD in Chinese and Indian populations.     

Association between interleukin-10 promoter polymorphisms and endometriosis: A meta-analysis

To investigate the influence of the interleukin-10 gene promoter polymorphisms on the susceptibility of endometriosis, we examined the association by performing a meta-analysis. The PubMed, Embase, HuGE Navigator and CNKI were searched to identify eligible studies. We then conducted a meta-analysis to examine the association between interleukin-10 gene promoter polymorphisms and endometriosis. Eight case–control studies which examined the association between the IL-10 gene promoter polymorphisms and the susceptibility to endometriosis were finally included in the meta-analysis. Meta-analysis of the IL-10 − 592 A/C polymorphisms showed a significant increased risk of endometriosis in the overall and Asian population in all genetic models and allele contrast. However, meta-analysis of the IL-10 − 1082 A/G and IL-10 − 819 T/C polymorphisms showed no association with endometriosis in all genetic models and allele contrast in the overall and Asian population samples. In addition, there was not a significant association between the IL-10 − 592 A/C gene promoter polymorphisms with the severity of endometriosis.     

Association of glutathione S-transferase M1/T1 polymorphisms with susceptibility to vitiligo

Background

Some studies suggested that Glutathione S-transferases M1/T1(GSTM1/T1) null polymorphisms may be associated with the risk of vitiligo.

Aims

The purpose of this study is to further evaluate the association between GSTM1/T1 null polymorphisms and the susceptibility to vitiligo.

Methods

We carried out a retrieval of studies in the databases. Odds ratios (OR) and 95% confidence intervals (95% CIs) were used to assess the strength of this association. We analyzed the data using Stata 11.0.

Results

Six case–control studies including 1358 cases and 1673 controls were included in this meta-analysis. Our overall results showed the GSTM1 or GSTT1 null polymorphism was associated with vitiligo (GSTM1:OR = 1.59, 95% CI: 1.21–2.08, P = 0.001; GSTT1: OR = 1.30, 95% CI: 1.12–1.51, P = 0.001). In the subgroup analysis, the GSTM1 null polymorphism might be a genetic risk factor to vitiligo in East Asian (OR = 1.71, 95% CI: 1.12–2.63, P = 0.014) but not in the Mediterranean, however individuals with the GSTT1 null polymorphism in the Mediterranean (OR = 1.76, 95% CI: 1.15–2.71, P = 0.010) but not in East Asian have a greater predisposition to vitiligo. In addition there was also a significant trend toward an association with the combination of the GSTM1 null and GSTT1 null in either East Asians or Mediterraneans.

Conclusion

The GSTM1/T1 null polymorphisms may be associated with vitiligo. More studies are needed to confirm this conclusion.     

Association study of IL28B: rs12979860 and rs8099917 polymorphisms with SVR in patients infected with chronic HCV genotype 1 to PEG-INF/RBV therapy using systematic meta-analysis

Recently, genome-wide associated studies (GWAS) have identified that host genetics IL28B SNPs rs12979860 and rs8099917 were significantly associated with SVR in patients infected with chronic HCV genotype 1 to PEG-INF/RBV therapy. Results from these studies remain conflicting. We conducted this meta-analysis to estimate the overall association of SVR with rs12979860 and rs8099917. We searched the PubMed, Embase, Scholar Google, ISI Web of Knowledge, and Chinese National Knowledge Infrastructure (CNKI) databases for all articles before July 30, 2012. The odds ratio (OR) corresponding to the 95% confidence interval (CI) was used to assess the association. The statistical heterogeneity among studies was assessed with the I² statistics. Begg's test and Egger's test were performed to evaluate the publication bias. Eventually, twenty studies were selected for the meta-analysis. The IL-28B SNPs rs12979860 genotype CC and rs8099917 genotype TT significantly positive associated with SVR in patients infected chronic HCV genotype 1 to PEG-INF/RBV therapy (OR = 4.473, 95% CI = 3.814–5.246, OR = 5.171, 95% CI = 4.372–6.117 respectively). The results suggested that rs12979860 genotype CC and rs8099917 genotype TT could be used as independent predictors of the HCV-1 infected patients.     

Genetic variants in TERT–CLPTM1L genetic region associated with several types of cancer: A meta-analysis

Background

TERT–CLPTM1L genomic region has been extensively associated with several types of cancer. However, results were inconsistent. We performed this meta-analysis to estimate the association between TERT (rs2736100, rs2736098), as well as CLPTM1L (rs402710, rs401681) polymorphisms and cancer risk.

Methods

Electronic search in PubMed, EMBASE and China National Knowledge Infrastructure (CNKI) was conducted to select the studies. Studies containing available genotype frequencies of those 4 polymorphisms were chosen, and overall odds ratio (OR) with 95% confidence interval (CI) was used to assess the association.

Results

The final meta-analysis included 16 published case–control studies. Increased cancer risk was found between TERT-rs2736100, as well as CLPTM1L-rs402710 and cancer susceptibility. In addition, we found an increased risk of cancer in both rs2736098 and rs401681 homozygous variant genetic model.

Conclusions

This meta-analysis suggested that TERT–CLPTM1L genomic region was associated with increased risk of cancer. To validate the association between these polymorphisms and cancer susceptibility, further studies with larger participants are needed.     

基于CNKI和PubMed数据库的双歧杆菌研究文献分析

目的统计分析国内外已发表的与双歧杆菌相关的期刊文献,了解其中的研究热点与发展趋势,为相关科研工作者提供参考。方法研究资料来源于CNKI和PubMed数据库,应用文献计量学的方法对两个数据库所收录的双歧杆菌相关文献进行分析。结果截至2018年8月15日,CNKI和PubMed分别收录了9277和5130篇相关文献。在数量上,国内外对双歧杆菌的研究都从20世纪90年代开始快速增长。从学科分布和关键词来看,中外研究共同关注了消化道疾病和儿科学,同时中外研究侧重点又有明显的差异。国内研究机构参与发表在国际杂志上的文章数量较多,但是其中作为第一发表单位的文章数量偏少。结论双歧杆菌相关的基础与应用研究还有许多需要深入和拓展的方面,研究者应当在相关领域进行实质性突破。     

全球红火蚁研究状况的文献计量分析

红火蚁Solenopsis invicta Buren是一种严重危害农林业生产、生命健康、公共安全和生态环境的重大外来入侵害虫,也是全世界入侵生物学的一个研究热点。为了全面客观地了解近国内外红火蚁研究的发展脉络、变化趋势和研究规律,为从事该害虫研究和利用的学者与决策者提供数据参考,本文从文献计量学角度分析了红火蚁在CNKI数据库和Web of Science数据库中的文献情况。在CNKI数据库中,分析了文献的类型分布、主题、研究层次、年度趋势、来源机构、高贡献作者以及高被引文献和资助基金的情况。在Web of Science数据库中,分析了文献年度趋势、作者的国别和机构、高贡献作者、资助资金以及高被引文献的情况。整体来看,国内的研究侧重红火蚁的入侵防治,技术和方法方面的报道受到同行的重视;而国外方面,则是基础研究成果受到更多传播和引用。     

The RTK/ERK pathway is associated with prostate cancer risk on the SNP level: A pooled analysis of 41 sets of data from case–control studies

Prostate cancer (PCa) is a malignant disease influencing numerous men worldwide every year. However, the exact pathogenesis and the genes, environment, and other factors involved have not been explained clearly. Some studies have proposed that cell signaling pathways might play a key role in the development and progression of PCa. According to our previous study, the RTK/ERK pathway containing nearly 40 genes was associated with PCa risk. On the basis of these genes, we conducted a meta-analysis with our own Chinese Consortium for Prostate Cancer Genetics (ChinaPCa) study and available studies in the databases to describe the association between the pathway and PCa on the SNP level. The results suggested that rs4764695/IGF1 (recessive model: pooled OR = 0.92, 95%CI = 0.852–0.994, P = 0.034; I² = 0%, P = 0.042; allele analysis: pooled OR = 0.915, 95%CI = 0.874–0.958, P = 0; I² = 0%, P = 0.424; codominant model: OR = 0.835, 95%CI = 0.762–0.916, P = 0; I² = 0%, P = 0.684) and rs1570360/VEGF (recessive model: OR = 0.596, 95%CI = 0.421–0.843, P = 0.003; I² = 23.9%, P = 0.269; codominant model: OR = 0.576, 95%CI = 0.404–0.820, P = 0.002; I² = 49.1%, P = 0.140) were significantly associated with PCa. In subgroup analysis, the relationship was also found in Caucasians for IGF1 (dominant model: OR = 0.834, 95%CI = 0.769–0.904, P = 0; allele analysis: OR = 0.908, 95%CI = 0.863–0.955, P = 0; AA vs CC: OR = 0.829, 95%CI = 0.750–0.916, P = 0; AC vs CC: OR = 0.837, 95%CI = 0.768–0.912, P = 0). In addition, in Asians (allele analysis: OR = 0.21, 95%CI = 0.168–0.262, P = 0) and Caucasians (recessive model: OR = 0.453, 95%CI: 0.240–0.855, P = 0.015; codominant model: OR = 0.464, 95%CI = 0.240–0.898, P = 0.023) for VEGF, the association was significant. The results indicated that rs4764695/IGF1 and rs1570360/VEGF might play a key role in the development and progression of PCa. On the SNP level, we suggest that the study gives us a new view of gene-pathway analysis and targeted therapy for PCa.     

基于文献计量的国内园艺疗法研究现状及趋势分析

以中国知网(CNKI)中截至2019年2月27日的224篇中文文献和Web of Science (WOS)中12篇中国学者发表的英文文献为对象,采用文献计量法,分析国内园艺疗法研究现状及趋势。研究发现,我国园艺疗法研究热度持续上升,文献数量不断增加,但研究网络分支有限、研究深度有待加深。医药卫生、工业技术和农业科学是其主要研究领域;景观设计和康复是最为突出的研究热点。最后,针对国内园艺疗法研究在研究力量、资助、学科、刊物、内容和趋势等六个方面的局限提出建议,并对未来研究方向做出展望。     

中国荒漠草原的研究态势与热点分析——基于文献计量研究

荒漠草原是我国草原的重要组成部分,对保障粮食安全、生态安全具有极其重要的作用。为了解中国该领域研究态势,运用文献计量方法,基于36年间国内外发表的3651篇论文,分析了发文量、发文来源、被引频次、主要作者、研究机构和研究热点等。结果表明：（1）2000年后关于荒漠草原的论文数量增幅较大,年均发表超160篇,但篇均被引频次、高质量学术期刊发文量和创新性研究成果较少,整体发文质量还有待进一步提高;（2）具有创新性的评价方法和理论研究一直备受关注,而利用荟萃分析方法对某一研究领域进展的分析得到了学者们的认可;（3）韩国栋、宋乃平、卫智军、周广胜等是荒漠草原研究的主要贡献者,内蒙古农业大学和宁夏大学等单位在发文机构合作间的节点上发挥了重要作用,并形成了荒漠草原研究的网络核心,但中文论文研究机构间的合作较英文论文离散程度高,特别是与国外机构的合作相对较少;（4）研究的热点主要集中在人类活动和气候变化对荒漠草原植被-土壤系统的影响、荒漠草原植被生产力及其影响因素、利用孢粉研究植被和环境变迁等方面。未来荒漠草原的研究应加强国内外机构和人员间的合作创新,从多尺度、多维度应用多学科知识、多技术手段,加强人类活动和气候条件相互作用对荒漠草原植物群落结构进化过程、地上与地下生态过程耦联关系、不同营养级之间内在机理的分析和探讨。通过深度挖掘荒漠草原基础数据,以促进高影响力、高质量成果的产出,实现科研成果量变与质变并举、基础研究与实际应用并重,期望能给荒漠草原的相关研究提供借鉴和启发新方向,为中国草地建设和决策提供科学依据。