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Auditory brainstem response (ABR) techniques, an electrophysiological far-field recording method widely used in clinical evaluation of human hearing, were adapted for fishes to overcome the major limitations of traditional behavioral and electrophysiological methods (e.g., invasive surgery, lengthy training of fishes, etc.) used for fish hearing research. Responses to clicks and tone bursts of different frequencies and amplitudes were recorded with cutaneous electrodes. To evaluate the effectiveness of this method, the auditory sensitivity of a hearing specialist (goldfish, Carassius auratus) and a hearing generalist (oscar, Astronotus ocellatus) was investigated and compared to audiograms obtained through psychophysical methods. The ABRs could be obtained between 100 Hz and 2000 Hz (oscar), and up to 5000 Hz (goldfish). The ABR audiograms are similar to those obtained by behavioral methods in both species. The ABR audiogram of curarized (i.e., Flaxedil-treated) goldfish did not differ significantly from two previously published behavioral curves but was lower than that obtained from uncurarized fish. In the oscar, ABR audiometry resulted in lower thresholds and a larger bandwidth than observed in behavioral tests. Comparison between methods revealed the advantages of this technique: rapid evaluation of hearing in untrained fishes, and no limitations on repeated testing of animals. Accepted: 8 August 1997  相似文献
强噪声暴露后听觉脑干电反应及皮层电反应的变化   总被引:5,自引:2,他引:3  
魏保龄  汤浩 《生理学报》1994,46(6):553-560
为了观察噪声作用豚鼠后,在暂时性或移和永久性阈移期间,听觉末梢和听觉各级中枢电反庆的变化规律,我们进行了62d的测定。听神经电反应振幅减小29%(P<0.05),耳蜗核电反应振幅减小28%(P<0.05),上橄榄核电反应反而增加21%(P<0.05),中脑下丘的电反应振幅进而增大37%(P<0.05),听觉皮层电反应振幅却意外地增加131%(P<0.001)。这说明强噪声(125dB 150min  相似文献
猫耳蜗电图中N_2波起源的分析   总被引:4,自引:0,他引:4  
魏保龄  康健  曲非 《生理学报》1986,38(5):535-538
在35只猫进行了耳蜗电图、听觉脑干电反应及耳蜗核局部电位的同时描记,将普鲁卡因或海人酸微量注入耳蜗核内,观察电位的变化,以分析耳蜗电图中N_2 波的起源。实验结果表明:猫的 N_2 波来源于外周第一级神经元冲动的成分和耳蜗核电活动的成分。  相似文献
有关猫听觉脑干电反应(ABR)两耳干涉作用的研究   总被引:4,自引:1,他引:3  
用不同声强稳态白噪声和短声同时分别刺激两耳,观察白噪声负荷侧耳蜗破坏前后另一侧ABR的改变,探讨两耳干涉作用及其可能的机制。结果显示,对侧耳蜗破坏前,40dB和75dB白噪声对0dB、45dB、70dB和75dBSPL的短声诱发的ABR各波振幅均有明显影响(P<0.050.01)。耳蜗破坏后,同样条件下记录的ABR振幅基本无明显变化(P>0.05)。提示白噪声对短声有一定的干涉作用。短声为70dBSPL时ABRP1波振幅的减小可能与中枢离中控制相关。  相似文献
早产儿听神经通路的发育神经生物学特性   总被引:4,自引:0,他引:4       下载免费PDF全文
系统地观察了不同周龄正常早产儿脑干听觉诱发反应的特性,结果表明①刺激强度80、60dBnHL时Ⅰ波35周前,Ⅲ、Ⅴ波36周前明显长于足月新生儿(P<0.05,P<0.01),刺激强度30dBnHL时Ⅰ波35周前,Ⅲ、Ⅴ波至37周仍明显长于足月新生儿(P<0.05,P<0.01);②≤32周Ⅰ—Ⅲ、Ⅰ—ⅤIPL与足月新生儿比较分别延长0.40和0.55ms,33—35周平均延长0.31和0.29ms,36周接近足月新生儿;③Ⅰ、Ⅲ、Ⅴ波潜伏期—成熟函数曲线的斜率≤32—33周时分别为0.62、0.66和0.80ms/week,33—35周时分别为0.09、0.03和0.06ms/week,35—36周时分别为0.00、0.33和0.38ms/week。  相似文献
有关猫交叉听力及其对检测耳影响的初步研究   总被引:3,自引:0,他引:3  
目的研究猫的交叉听力现象及其产生机理,初步探讨交叉听力对检测耳ABR振幅的影响。方法用彻底破坏一侧耳蜗的方法,观察16只听力正常家猫的交叉听力现象及其对检测耳的影响。结果①当短声强度≥75dB(SPL)时,开始出现交叉听力波形,声强增至95dB时,交叉听力波形最典型。②95dB短声产生的交叉听力波形可被40或45dB(SPL)的稳态白噪声(SWN)完全屏蔽掉。③在同一时间轴中比较95dB短声诱发的ABR和交叉听力波形,发现交叉听力之波谷恰与ABR之pⅢ、pⅣ波峰相对应。④两耳均正常时对侧耳负荷的40dBSWN可使95dB短声诱发的ABR之pⅢ、pⅣ波振幅增大,且具统计学意义(P<0.01)。结论交叉听力对ABR振幅的影响取决于两者的波峰与波谷在同一时间轴上的对应情况,声强较大时记录到的ABR,实质上是交叉听力与刺激侧产生的ABR在同一时间轴上的综合电位。  相似文献
Summary Auditory brainstem responses (ABRs) were characterized at 37 °C in ground squirrels (Citellus lateralis) which were implanted with recording screws to record ABRs, and a thermistor to record brain temperature. After two weeks ground squirrels were reanesthetized and tone pips and clicks were delivered through a TDH-49 headphone.Recorded ABRs were found to vary in a predictable manner as a function of stimulus frequency and intensity. At intensities above 50 dB SPL, ABRs could be recorded over the range tested (2–32 kHz). An 8 kHz tone pip was the best frequency for recording ABRs at the lowest stimulus intensities. Latencies decreased as stimulus frequencies increased from 4 kHz to 32 kHz.  相似文献
Aminoglycoside antibiotics produce varying degrees of ototoxicity, dependent on dosage time, in animals synchronized for rhythm study. Herein, we illustrate the use of an economical and reliable system to telemeter body temperature of laboratory animals as an endogenous marker rhythm for gentamicin-induxed ototoxicity. Two groups of 3 male Sprague-Dawley rats (250-400 gm) were housed in separate cages in a temperature-controlled room programmed with a 12:12 LD schedule and monitored for hearing thresholds at the frequencies of 8kHz, 16kHz, 24kHz and 32kHz at 2-week intervals. Each rat was dosed with 100 mg/kg/day gentamicin subcutaneously for a duration of 28 days. The animals from one group were dosed at their daily temperature maximum, while the animals of the other group were dosed at their daily temperature minimum. Both after 14 and 28 days of gentamicin treatment there was no important changes in auditory thresholds from baseline values when treatment was timed daily to the circadian peak of body temperature. Animals dosed daily at the trough of the circadian temperature rhythm evidenced an auditory threshold shift of between 5 and 25 dB after 14 days of treatment and a total hearing loss (80-90 dB) after 28 days of such treatment. These results document a dramatically greater level of hearing loss induced in those animals dosed with gentamicin at the body temperature trough (diurnal rest span) as compared to those dosed at the acrophase (nocturnal activity span). The findings indicate that the peak and trough of the circadian pattern of body temperature serve as meaningful markers of the resistance and susceptibility, respectively, of gentamicin-induced ototoxicity in rodent models.  相似文献
本文通过20例听力正常人和10例听力正常豚鼠研究了白噪声对耳蜗电图(ECochG)和听觉脑干电反应(ABR)的干涉作用。实验结果表明,白噪声比短声(信号)的声强级低30dB(SL)以上时,ECochG和ABR的振幅仅轻微减小。白噪声与短声的声强级相等时,ECochG与ABR的振幅和出现率会明显受到干涉而减小,甚至完全消失。但是,此时的耳蜗微音器电位(CM)并未观察到有明显的变化。这意味着白噪声对ECochG和ABR的干涉作用主要与围绕毛细胞基底部的突触产生的抑制密切相关。由于白噪声对ABR各波的干涉有些差异,所以认为这种抑制,可能既包括脑中抑制也包括侧方抑制。  相似文献
康健  魏保龄 《生理学报》1986,38(3):259-265
在33例猫将普鲁卡因或海人酸微量注入耳蜗核(CN)和上橄榄复合体(SOC)内,观察ABR的相应改变,以分析P_(2a)和P_(2b)波的来源。猫P_(2a)波的出现率与电极导联有关,颅顶-颈后为90%,颅顶-乳突仅为18%。普普卡因注入CN后,同侧耳短声诱发的ABR仅保留P_1波,对侧耳的则无改变。海人酸注入CN后,P_1和P_(2a)存留,P_(2a)不减小反而增大。普鲁卡因注入双侧SOC,可使P_3、P_4和P_5消失。这些结果提示,P_(2a)波主要起源于CN区域内的第一级听觉传入神经元轴突并受第二级神经元负电位的影响,P_(2b)波主要起源于SOC以下的第二级听觉传入神经元,猫的P_(2a)和P_(2a)波与对侧脑干结构无关。  相似文献
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