Adenosine triphosphate (ATP) and its metabolites adenosine diphosphate, adenosine monophosphate, and adenosine in purinergic signaling pathway play important roles in many diseases. Activation of P2 receptors (P2R) channels and subsequent membrane depolarization can induce accumulation of extracellular ATP, and furtherly cause kinds of diseases, such as pain- and immune-related diseases, cardiac dysfunction, and tumorigenesis. Active ingredients of traditional Chinese herbals which exhibit superior pharmacological activities on diversified P2R channels have been considered as an alternative strategy of disease treatment. Experimental evidence of potential ingredients in Chinese herbs targeting P2R and their pharmacological activities were outlined in the study.
Russian Journal of Bioorganic Chemistry - The grape is a highly valuable food stuff owing to the presence of a number of biologically active substances, and vitamins occupy a special place among... 相似文献
In 2010–2011, experimental commercial cultivation of 14 species of hermatypic corals was carried out using the method of donor colony fragmentation. The transplants successfully survived on experimental frame installations. The coral colonies that were recovered from the fragments became attached to the frame installations in a similar way to their attachment on natural substrata. After 1 year, the size of the trans-plants was found to have increased by 275%. The newly formed artificial coral community was colonized by the damselfish Dascyllus reticulates (Pomacentridae); the species is a common coral fish species that lives on natural reefs. 相似文献
In July 2010, abnormally high water temperature (25–29°C), as well as increased biomass and phytoplankton production caused intensive development of heterotrophic bacteria and heterotrophic nanoflagellates. It was found that the abundance, biomass, and production of heterotrophic bacterioplankton, as well as the abundance and biomass of heterotrophic nanoflagellates, and the number of planktonic viruses, which were calculated on average for the reservoir under study, turned out to be higher in the years with lower water temperature (20–23°C). The virus-induced mortality of bacterioplankton in the Oka River and the Cheboksary Reservoir averaged 25.4 ± 3.4 and 22.4 ± 2.7% of the daily bacterioplankton production. 相似文献
The value of the voltage fall across the anode sheath is found as a function of the current density. Analytic solutions are obtained in a wide range of the ratio of the directed velocity of plasma electrons v0 to their thermal velocity vT. It is shown that the voltage fall in a one-dimensional collisionless anode sheath is always negative. At the small values of v0/vT, the obtained expression asymptotically transforms into the Langmuir formula. Generalized Bohm’s criterion for an electric discharge with allowance for the space charge density ρ(0), electric field E(0), ion velocity vi(0), and ratio v0/vT at the plasma-sheath interface is formulated. It is shown that the minimum value of the ion velocity vi*(0) corresponds to the vanishing of the electric field at one point inside the sheath. The dependence of vi* (0) on ρ(0), E(0), and v0/vT determines the boundary of the existence domain of stationary solutions in the sheath. Using this criterion, the maximum possible degree of contraction of the electron current at the anode is determined for a short high-current vacuum arc discharge. 相似文献
Results are presented from experimental studies of the structure of the compressed plasma of a Z-pinch produced during the implosion of a foam-wire load at the current of up to 3 MA. The foam-wire load consisted of two nested cylindrical cascades, one of which was a solid or hollow cylinder made of low-density agar-agar foam, while the other was a wire array. The wall thickness of a hollow foam cylinder was 100–200 μm. The images of the pinch and its spectrum obtained with the help of multiframe X-ray cameras and a grazing incidence spectrograph with a spatial resolution were analyzed. Data on the spatial structure of the emitting regions and the soft X-ray (SXR) spectrum of the Z-pinch in the final stage of compression of a foam-wire load were obtained. The implosion modes characterized by the formation of hot regions during implosion of such loads were revealed. The characteristic scale lengths of the hot regions were determined. It is shown that the energy distribution of SXR photons in the energy range from 80 eV to 1 keV forms the spatial structure of Z-pinch images recorded during the implosion of foam-wire loads. It is revealed that the spectral density of SXR emission in the photon energy range of 300–600 eV from hot Z-pinch regions exceeds the spectral density of radiation from the neighboring Z-pinch regions by more than one order of magnitude. Groups of lines related to the absorption and emission of radiation by atoms and multicharged ions of carbon and oxygen in the outer foam cascade of a foam-wire load were recorded for the first time by analyzing the spatial distribution of the SXR spectra of multicharged ions of the Z-pinch. The groups of absorption lines of ions (C III, O III, O IV, and O VI) corresponding to absorption of SXR photons in the Z-pinch of a tungsten wire array, which served as the inner cascade of a foam-wire load, were identified. The plasma electron temperature measured from the charge composition of carbon and oxygen ions in the outer agar-agar foam cascade was 10–40 eV. During the implosion of foam-wire loads at currents of up to 3 MA, SXR pulses (hν > 100 eV) with a duration of 10 ns and peak power of 3 TW were detected. It is shown that the temporal profile of single-peak and double-peak SXR pulses can be controlled by varying the parameters of the outer and inner cascades of the foam-wire load. 相似文献
Results are presented from experiments on the formation of an internal electron transport barrier near the q = 1.5 rational surface in the T-10 tokamak. The experiments were carried out in the regime with off-axis electron cyclotron resonance (ECR) heating followed by a fast plasma current ramp-up. After suppressing sawtooth oscillations by off-axis ECR heating, an internal transport barrier began to form near the q = 1.5 rational surface. In the phase of the current ramp-up, the quality of the transport barrier improved; as a result, the plasma energy confinement time increased 2–2.5 times. The intentionally produced flattening of the profile of the safety factor q(r) insignificantly affected magnetohydrodynamic activity in the plasma column in spite of the theoretical possibility of formation of substantial m/n = 3/2 and 2/1 magnetic islands. Conditions are discussed under which the flattening of the profile of the safety factor q near low-order rational surfaces leads to the formation of either an internal transport barrier or the development of an island magnetic structure induced by tearing modes. 相似文献