全文获取类型
收费全文 | 3161篇 |
免费 | 363篇 |
国内免费 | 7篇 |
出版年
2021年 | 31篇 |
2019年 | 34篇 |
2018年 | 40篇 |
2017年 | 41篇 |
2016年 | 54篇 |
2015年 | 75篇 |
2014年 | 97篇 |
2013年 | 108篇 |
2012年 | 131篇 |
2011年 | 137篇 |
2010年 | 102篇 |
2009年 | 84篇 |
2008年 | 134篇 |
2007年 | 137篇 |
2006年 | 113篇 |
2005年 | 147篇 |
2004年 | 102篇 |
2003年 | 102篇 |
2002年 | 118篇 |
2001年 | 93篇 |
2000年 | 110篇 |
1999年 | 73篇 |
1998年 | 34篇 |
1997年 | 41篇 |
1996年 | 35篇 |
1995年 | 33篇 |
1994年 | 36篇 |
1993年 | 39篇 |
1992年 | 49篇 |
1991年 | 58篇 |
1990年 | 51篇 |
1989年 | 50篇 |
1988年 | 48篇 |
1987年 | 48篇 |
1986年 | 47篇 |
1985年 | 37篇 |
1984年 | 53篇 |
1983年 | 42篇 |
1982年 | 40篇 |
1981年 | 38篇 |
1980年 | 33篇 |
1979年 | 36篇 |
1978年 | 29篇 |
1976年 | 35篇 |
1975年 | 44篇 |
1974年 | 31篇 |
1973年 | 46篇 |
1972年 | 35篇 |
1971年 | 31篇 |
1968年 | 29篇 |
排序方式: 共有3531条查询结果,搜索用时 312 毫秒
81.
Spangled perch (Leiopotherapon unicolor) in the southern Murray‐Darling Basin: Flood dispersal and short‐term persistence outside its core range 下载免费PDF全文
Iain Ellis Nick Whiterod Danielle Linklater Deborah Bogenhuber Paul Brown Dean Gilligan 《Austral ecology》2015,40(5):591-600
The spangled perch Leiopotherapon unicolor is considered a rare vagrant in the southern Murray‐Darling Basin, Australia, due to its intolerance of the relatively cool water temperatures that prevail during winter months. This study details 1342 records of the species from 68 locations between 2010 and 2014 outside its accepted ‘core adult range’ following widespread flooding during 2010 and 2011. Although records of the species declined over 2013, L. unicolor remained resident in the southern Murray‐Darling Basin as of April 2014. The species persisted in several locations for three consecutive winters with recruitment documented at two sites. This study represents the first identification of the dispersal of large numbers of L. unicolor into the southern Murray‐Darling Basin, persistence beyond a single winter, and recruitment by the species in habitats south of its recognized ‘core adult range’. Targeted research would determine the potential for predicted environmental changes (artificially warmer drainage wetlands, climate change and greater floodplain connectivity) to facilitate longer term persistence and range expansion by the species in the southern Murray‐Darling Basin. 相似文献
82.
Amy Weintrob Ionut Bebu Brian Agan Alona Diem Erica Johnson Tahaniyat Lalani Xun Wang Mary Bavaro Michael Ellis Katrin Mende Nancy Crum-Cianflone 《PloS one》2015,10(5)
BackgroundHIV-infected persons have increased risk of MRSA colonization and skin and soft-tissue infections (SSTI). However, no large clinical trial has examined the utility of decolonization procedures in reducing MRSA colonization or infection among community-dwelling HIV-infected persons.Methods550 HIV-infected adults at four geographically diverse US military HIV clinics were prospectively screened for MRSA colonization at five body locations every 6 months during a 2-year period. Those colonized were randomized in a double-blind fashion to nasal mupirocin (Bactroban) twice daily and hexachlorophene (pHisoHex) soaps daily for 7 days compared to placeboes similar in appearance but without specific antibacterial activity. The primary endpoint was MRSA colonization at 6-months post-randomization; secondary endpoints were time to MRSA clearance, subsequent MRSA infections/SSTI, and predictors for MRSA clearance at the 6-month time point.ResultsForty-nine (9%) HIV-infected persons were MRSA colonized and randomized. Among those with 6-month colonization data (80% of those randomized), 67% were negative for MRSA colonization in both groups (p = 1.0). Analyses accounting for missing 6-month data showed no significant differences could have been achieved. In the multivariate adjusted models, randomization group was not associated with 6-month MRSA clearance. The median time to MRSA clearance was similar in the treatment vs. placebo groups (1.4 vs. 1.8 months, p = 0.35). There was no difference on subsequent development of MRSA infections/SSTI (p = 0.89). In a multivariable model, treatment group, demographics, and HIV-specific factors were not predictive of MRSA clearance at the 6-month time point.ConclusionA one-week decolonization procedure had no effect on MRSA colonization at the 6-month time point or subsequent infection rates among community-dwelling HIV-infected persons. More aggressive or novel interventions may be needed to reduce the burden of MRSA in this population.
Trial Registration
ClinicalTrials.gov NCT00631566相似文献83.
Christine Thai Yen Ying Lim Victor L. Villemagne Simon M. Laws David Ames Kathryn A. Ellis Stephanie R. Rainey-Smith Ralph N. Martins Colin L. Masters Christopher C. Rowe Paul Maruff Australian Imaging Biomarkers Lifestyle Research Group 《PloS one》2015,10(10)
High levels of β-amyloid (Aβ) in the brain and carriage of the APOE ε4 allele have each been linked to cognitive impairment in cognitively normal (CN) older adults. However, the relationship between these two biomarkers and cognitive decline is unclear. The aim of this study was to investigate the relationship between cerebral Aβ level, APOE ε4 carrier status, and cognitive decline over 18 months, in 317 cognitively healthy (CN) older adults (47.6% males, 52.4% females) aged between 60 and 89 years (Mean = 69.9, SD = 6.8). Cognition was assessed using the Cogstate Brief Battery (CBB) and the California Verbal Learning Test, Second Edition (CVLT-II). Planned comparisons indicated that CN older adults with high Aβ who were also APOE ε4 carriers demonstrated the most pronounced decline in learning and working memory. In CN older adults who were APOE ε4 non-carriers, high Aβ was unrelated to cognitive decline in learning and working memory. Carriage of APOE ε4 in CN older adults with low Aβ was associated with a significantly increased rate of decline in learning and unexpectedly, improved cognitive performance on measures of verbal episodic memory over 18 months. These results suggest that Aβ and APOE ε4 interact to increase the rate of cognitive decline in CN older adults and provide further support for the use of Aβ and APOE ε4 as biomarkers of early Alzheimer’s disease. 相似文献
84.
Tamalee Roberts Joel Barratt Indy Sandaradura Rogan Lee John Harkness Deborah Marriott John Ellis Damien Stark 《PloS one》2015,10(3)
Leishmaniasis is a vector borne disease caused by protozoa of the genus Leishmania. Human leishmaniasis is not endemic in Australia though imported cases are regularly encountered. This study aimed to provide an update on the molecular epidemiology of imported leishmaniasis in Australia. Of a total of 206 biopsies and bone marrow specimens submitted to St Vincent’s Hospital Sydney for leishmaniasis diagnosis by PCR, 55 were found to be positive for Leishmania DNA. All PCR products were subjected to restriction fragment length polymorphism analysis for identification of the causative species. Five Leishmania species/species complexes were identified with Leishmania tropica being the most common (30/55). Travel or prior residence in a Leishmania endemic region was the most common route of acquisition with ~47% of patients having lived in or travelled to Afghanistan. Cutaneous leishmaniasis was the most common manifestation (94%) with only 3 cases of visceral leishmaniasis and no cases of mucocutaneous leishmaniasis encountered. This report indicates that imported leishmaniasis is becoming increasingly common in Australia due to an increase in global travel and immigration. As such, Australian clinicians must be made aware of this trend and consider leishmaniasis in patients with suspicious symptoms and a history of travel in endemic areas. This study also discusses the recent identification of a unique Leishmania species found in native kangaroos and a potential vector host which could create the opportunity for the establishment of a local transmission cycle within humans. 相似文献
85.
Camillo Bérénos Philip A. Ellis Jill G. Pilkington S. Hong Lee Jake Gratten Josephine M. Pemberton 《Molecular ecology》2015,24(8):1810-1830
Knowledge of the underlying genetic architecture of quantitative traits could aid in understanding how they evolve. In wild populations, it is still largely unknown whether complex traits are polygenic or influenced by few loci with major effect, due to often small sample sizes and low resolution of marker panels. Here, we examine the genetic architecture of five adult body size traits in a free‐living population of Soay sheep on St Kilda using 37 037 polymorphic SNPs. Two traits (jaw and weight) show classical signs of a polygenic trait: the proportion of variance explained by a chromosome was proportional to its length, multiple chromosomes and genomic regions explained significant amounts of phenotypic variance, but no SNPs were associated with trait variance when using GWAS. In comparison, genetic variance for leg length traits (foreleg, hindleg and metacarpal) was disproportionately explained by two SNPs on chromosomes 16 (s23172.1) and 19 (s74894.1), which each explained >10% of the additive genetic variance. After controlling for environmental differences, females heterozygous for s74894.1 produced more lambs and recruits during their lifetime than females homozygous for the common allele conferring long legs. We also demonstrate that alleles conferring shorter legs have likely entered the population through a historic admixture event with the Dunface sheep. In summary, we show that different proxies for body size can have very different genetic architecture and that dense SNP helps in understanding both the mode of selection and the evolutionary history at loci underlying quantitative traits in natural populations. 相似文献
86.
87.
88.
89.
The present study investigated how ease of imagery influences source monitoring accuracy. Two experiments were conducted in order to examine how ease of imagery influences the probability of source confusions of perceived and imagined completions of natural symmetric shapes. The stimuli consisted of binary pictures of natural objects, namely symmetric pictures of birds, butterflies, insects, and leaves. The ease of imagery (indicating the similarity of the sources) and the discriminability (indicating the similarity of the items) of each stimulus were estimated in a pretest and included as predictors of the memory performance for these stimuli. It was found that confusion of the sources becomes more likely when the imagery process was relatively easy. However, if the different processes of source monitoring—item memory, source memory and guessing biases—are disentangled, both experiments support the assumption that the effect of decreased source memory for easily imagined stimuli is due to decision processes and misinformation at retrieval rather than encoding processes and memory retention. The data were modeled with a Bayesian hierarchical implementation of the one high threshold source monitoring model. 相似文献
90.