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71.
Both single and graded administration of an anthracycline antibiotic adriablastine at a dose of 20 mg/kg to white rats have resulted in cardiomyocyte volume decrease, dystrophia and lysis of myofibrils, and reduction of mitochondrial surface density volume. Accumulations of myelin bodies of different configuration and diffuse myolysis were observed. Myelin bodies and diffuse myolysis of cardiomyocytes in adriablastine-induced cardiomyopathy are believed to be a morphological sign of lipid peroxidation. 相似文献
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N. P. Teryukova O. N. Pogodina G. I. Blinova V. A. Ivanov 《Cell and Tissue Biology》2011,5(6):586-594
The goal of this work consisted in study of the immunomodulating action of the cytostatic drug cyclophosphamide (CP) on the
natural cytotoxic activity of rat and mice splenocytes. The cytotoxicity of effector cells (EC) with respect to monolayer
cell lines of the Zajdela rat hepatoma and the HTC rat hepatoma and of the MH-22a mouse hepatoma was determined with the aid
of morphometric analysis. CP at a dose of 100 mg/kg 48 h after administration to animals has been shown to produce an immunomodulating
effect on cytotoxicity of splenocytes—a suppressive one with respect to cell-targets (CT) of Zajdela hepatoma and an immunopotentiating
one with respect to CT of HTC and MH-22 hepatomas. Possible mechanisms of the CP immunopotentiating action are discussed. 相似文献
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Cross Adam T. Stevens Jason C. Sadler Rohan Moreira-Grez Benjamin Ivanov Dmitry Zhong Hongtao Dixon Kingsley W. Lambers Hans 《Plant and Soil》2021,460(1-2):163-176
Plant and Soil - In water-limited areas, shrubs influence biological soil crust (biocrust) composition and diversity via soil microenvironment alterations and through modifying biotic interactions... 相似文献
77.
Vasilyeva A. D. Ivanov V. S. Yurina L. V. Indeykina M. I. Bugrova A. E. Kononikhin A. S. Nikolaev E. N. Rosenfeld M. A. 《Doklady. Biochemistry and biophysics》2021,501(1):419-423
Doklady Biochemistry and Biophysics - Plasminogen is a zymogenic form of plasmin, an enzyme that plays a fundamental role in the dissolution of fibrin clots as well as in many other physiological... 相似文献
78.
I. I. Mikhaleva V. T. Ivanov V. B. Voitenkov E. M. Vechkanov T. I. Bondarenko 《Russian Journal of Bioorganic Chemistry》2013,39(3):245-251
Biological properties of the known Delta Sleep-Inducing Peptide (DSIP, WAGGDASGE) were studied in vivo in comparison with those of a new DSIP-homologous peptide (WKGGNASGE — ([K 2, N 5]DSIP, KND). This new peptide was recently discovered as the 324–332 fragment of the human lysine-specific histone demethylase 3B (EC 1.14.11, Swiss-Prot: Q7LBC6.1, 1761 a.a.) in the course of a computer search in available databases of proteins and nucleic acids. This demethylase belongs to the JmjC-domain-containing family of histone demethylases which are encoded by the JMJD1B gene and present in tissues of various mammals. These studies confirmed our preliminary conclusions on the functional similarity between the biological activities of DSIP and KND. The examined antioxidative, anticonvulsive, and behavioral effects of KND proved to be more pronounced than those of DSIP. The obtained results additionally sup-ported our hypothesis about KND being an endogenous prototype of a “real” DSIP. 相似文献
79.
Boris Ivanov 《Free radical research》2013,47(3):217-227
In spinach thylakoids prepared from intact chloroplasts by shocking in the presence of ascorbate to preserve the operation of ascorbate peroxidase, the rate of oxygen uptake with methyl viologen as acceptor decreased in response to the addition of H2O2. Such a decrease was not observed in the presence of KCN or when the thylakoids lost ascorbate peroxidase activity. Illumination of intact chloroplasts in the presence of H2O2 and methyl viologen showed an initial rate of oxygen exchange, which is intermediate between the initial rate of oxygen evolution in the presence of H2O2 alone and steady-state oxygen uptake in the presence of methyl viologen. The data showed that monodehydroascorbate radical generated in ascorbate peroxidase reaction could compete with methyl viologen for electrons supplied by the electron transport chain in both thylakoids and intact chloroplasts. During the illumination of intact chloroplasts the rate of oxygen uptake increased. The presence of nigericin swiftly led to steady-state oxygen uptake, and to a clear-cut 1:1 relationship between the electron transport rate estimated from fluorescence assay and the electron transport rate determined from oxygen uptake, taking the stoichiometry 1O2:4e. The increase in oxygen uptake was attributed to the cessation of monodehydroascorbate radical generation brought about by consumption of intrachloroplast ascorbate in the peroxidase reactions, and the effects of nigericin were explained by acceleration of such consumption. The competition between methyl viologen and monodehydroascorbate radical in the intact chloroplasts was estimated under various conditions. 相似文献
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