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551.
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Rohit Shetty Ponnalagu Murugeswari Koushik Chakrabarty Chaitra Jayadev Himanshu Matalia Arkasubhra Ghosh Debashish Das 《Cytotherapy》2021,23(6):471-482
The end of 2019 saw the beginning of the coronavirus disease 2019 (COVID-19) pandemic that soared in 2020, affecting 215 countries worldwide, with no signs of abating. In an effort to contain the spread of the disease and treat the infected, researchers are racing against several odds to find an effective solution. The unavailability of timely and affordable or definitive treatment has caused significant morbidity and mortality. Acute respiratory distress syndrome (ARDS) caused by an unregulated host inflammatory response toward the viral infection, followed by multi-organ dysfunction or failure, is one of the primary causes of death in severe cases of COVID-19 infection. Currently, empirical management of respiratory and hematological manifestations along with anti-viral agents is being used to treat the infection. The quest is on for both a vaccine and a more definitive management protocol to curtail the spread. Researchers and clinicians are also exploring the possibility of using cell therapy for severe cases of COVID-19 with ARDS. Mesenchymal stromal cells are known to have immunomodulatory properties and have previously been used to treat viral infections. This review explores the potential of mesenchymal stromal cells as cell therapy for ARDS. 相似文献
553.
Parismita Kalita Harish Shukla Rohit Shukla Timir Tripathi 《Biochimica et Biophysica Acta (BBA)/General Subjects》2018,1862(6):1306-1316
The thiol-disulfide redox metabolism in platyhelminth parasites depends entirely on a single selenocysteine (Sec) containing flavoenzyme, thioredoxin glutathione reductase (TGR) that links the classical thioredoxin (Trx) and glutathione (GSH) systems. In the present study, we investigated the catalytic and structural properties of different variants of Fasciola gigantica TGR to understand the role of Sec. The recombinant full-length Sec containing TGR (FgTGRsec), TGR without Sec (FgTGR) and TGRsec without the N-terminal glutaredoxin (Grx) domain (?NTD-FgTGRsec) were purified to homogeneity. Biochemical studies revealed that Sec597 is responsible for higher thioredoxin reductase (TrxR) and glutathione reductase (GR) activity of FgTGRsec. The N-terminal Grx domain was found to positively regulate the DTNB-based TrxR activity of FgTGRsec. The FgTGRsec was highly sensitive to inhibition by auranofin (AF). The structure of FgTGR was modeled, and the inhibitor AF was docked, and binding sites were identified. Unfolding studies suggest that all three proteins are highly cooperative molecules since during GdnHCl-induced denaturation, a monophasic unfolding of the proteins without stabilization of any intermediate is observed. The Cm for GdnHCl induced unfolding of FgTGR was higher than FgTGRsec and ?NTD-FgTGRsec suggesting that FgTGR without Sec was more stable in solution than the other protein variants. The free energy of stabilization for the proteins was also determined. To our knowledge, this is also the first report on unfolding and stability analysis of any TGR. 相似文献
554.
Sleep and Biological Rhythms - Individual variability in preferred sleep timing is popularly described as chronotype. This study was conducted on 2105 subjects living in remote (500; without... 相似文献
555.
Priyadarsini Swagatika Panda Snehasmita Pashupathi M. Kumar Ajay Singh Rohit 《International journal of peptide research and therapeutics》2021,27(4):2333-2348
International Journal of Peptide Research and Therapeutics - Non-typhoidal salmonellosis (NTS) is a food-borne zoonotic disease of human and veterinary importance. Besides enteric infections, most... 相似文献
556.
Biotechnology Letters - The present research work explores the Nattokinase (NK) producing capacity of five Bacillus subtilis strains (MTCC 2616, MTCC 2756, MTCC 2451, MTCC 1427, and MTCC 7164)... 相似文献
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Reddy Samyuktha K. Sahu Santosh Kumar Khoja Rohit Kanu Sumit Singh Mandeep 《Plasmonics (Norwell, Mass.)》2022,17(1):257-263
Plasmonics - A complementary metal oxide semiconductor (CMOS) compatible photonic-plasmonic waveguide with nanoscale dimensions and better optical confinement has been proposed for the infrared... 相似文献
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Shanshan Li Jessica De La Cruz Steven Hutchens Somshuvra Mukhopadhyay Zachary K. Criss Rohit Aita Oscar Pellon-Cardenas Joseph Hur Patricia Soteropoulos Seema Husain Puneet Dhawan Lieve Verlinden Geert Carmeliet James C. Fleet Noah F. Shroyer Michael P. Verzi Sylvia Christakos 《Molecular and cellular biology》2021,41(1)