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431.
《Microbes and infection / Institut Pasteur》2014,16(12):991-997
Endosomal and cytosolic receptors engage recognition of mycobacterial-derived nucleic acids (MyNAs). In contrast, virulent mycobacteria may utilize nucleic acid recognition pathways to escape the host immune system. This short review will summarize the mechanisms by which MyNAs are sensed and how they influence host protective responses. 相似文献
432.
Sukhminder S. Osahan 《Biometrical journal. Biometrische Zeitschrift》1997,39(6):689-697
A two stage without replacement strategy is proposed for estimating the population mean of overlapping clusters of contacts of tuberculosis cases. This sampling strategy is an improvement over the two sampling strategies proposed by SINGH (1988). A numerical illustration is provided by taking two populations of tuberculosis contacts from New York City; the percentage gain in efficiency varies from 3.70 to 24.99. The proposed improved sampling strategy may be useful to other contagious diseases in the different fields of biomedical sciences or similar situations in other fields. 相似文献
433.
Bacteriological conversion in twenty urinary tuberculosis patients treated with ofloxacin, rifampin and isoniazid: a 10-year follow-up study 总被引:4,自引:0,他引:4
Alberte A. Castiñeiras P. Pérez-Pascual Estébanez J. Zarranz P. Della-Latta A. Herreras 《International microbiology》2002,5(3):139-144
Twenty patients with urinary tuberculosis were treated with ofloxacin (200 mg/day, 6 months), rifampin (600 mg/day, 3 months)
and isoniazid (300 mg/day, 3 months) between 1989 and 1990. All patients were new cases, diagnosed by observation and/or isolation
of Mycobacterium tuberculosis in one of the three morning urine samples. Bacteriological culture conversion (negativization) was assessed as a clinical
guide of efficacy, comparing it, as the only parameter, against a control group (150 patients) with urinary tuberculosis who
received conventional therapy. Bacteriological follow-up studies were performed in both groups monthly for 6 months, then
again 6 months later and then every year for 10 years after completion of treatment. In the 20 patients, the initial culture
was positive with over 100 colonies per culture (>50%); the smear was positive in 45% of the patients (most were 2+). All
strains were susceptible to rifampin, isoniazid and ofloxacin. Two patients discontinued treatment. Beginning with the first
month of treatment, the bacteriological conversion was 100%, 89.5% and 100% in the remaining controls. In the control group,
which received conventional treatment, the conversion was: 90%, 87%, 93% and 100% in the remaining controls. Treatment with
ofloxacin resulted in a bacteriological conversion similar to that following conventional treatment (p>0.05, Fisher's exact test). After 10 years of patient follow-up, we conclude that ofloxacin, in combination with rifampin
and isoniazid (both for 3 months only is effective against M. tuberculosis, providing satisfactory bacteriological and clinical efficacy.
Electronic Publication 相似文献