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31.
Döring B Pfitzer G Adam B Liebregts T Eckardt D Holtmann G Hofmann F Feil S Feil R Willecke K 《Cell and tissue research》2007,327(2):333-342
Connexin43 (Cx43) gap-junction channels are highly abundant in intestinal smooth muscle but their functional impact has not
been studied so far. Here, we have aimed to elucidate the functional role of Cx43 in the tunica muscularis of the mouse intestine
in vivo. Transgenic mice with conditional deletion of Cx43 in smooth muscle cells (SMC) were generated. Histological investigations
by immunofluorescence analyses and organ-bath recordings to assess the contractility of intestinal tissue strips were carried
out. Measurements of gastrointestinal transit and of the visceromotor response by utilizing a standardized colorectal distension
model to quantify alterations of visceral sensory function were also performed in SMC-specific Cx43 null mice and control
littermates. Histologically, we found thickening of the tunica muscularis and a 13-fold increase of neutrophil infiltration
of the gastrointestinal wall of SMC-specific Cx43 null mice. These animals also exhibited a decrease of 29% in gastrointestinal
transit time. In contrast, the visceromotor response to a standardized colorectal distension was elevated, as was the contractility
in SMC-specific Cx43 null mice, compared with controls. Thus, SMC-specific ablation of Cx43 in mice leads to morphological
and functional alterations of the intestinal tunica muscularis, to gastrointestinal motor dysfunction and to altered visceral
sensory function.
This study was supported by a grant from the German Research Association (Wi 270/25-1,2) to K.W. and in part by the IFORES
program of the University Hospital, Essen, Germany. 相似文献
32.
A recent study in Molecular Cell uncovered parallel yet distinct SUMOylation pathways that provide insights into molecular mechanisms of transrepression mediated by activated nuclear receptors LXRalpha/beta and PPARgamma, thereby clarifying receptor, signal, and gene specificity of transrepression in inflammatory processes. 相似文献
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