全文获取类型
收费全文 | 100篇 |
免费 | 29篇 |
出版年
2018年 | 2篇 |
2017年 | 5篇 |
2016年 | 1篇 |
2015年 | 2篇 |
2014年 | 5篇 |
2013年 | 4篇 |
2012年 | 4篇 |
2011年 | 6篇 |
2010年 | 3篇 |
2009年 | 2篇 |
2008年 | 5篇 |
2007年 | 9篇 |
2006年 | 6篇 |
2005年 | 2篇 |
2004年 | 3篇 |
2003年 | 4篇 |
2002年 | 4篇 |
2001年 | 4篇 |
2000年 | 6篇 |
1999年 | 5篇 |
1998年 | 2篇 |
1997年 | 2篇 |
1996年 | 3篇 |
1995年 | 2篇 |
1994年 | 1篇 |
1993年 | 3篇 |
1992年 | 3篇 |
1991年 | 2篇 |
1990年 | 2篇 |
1989年 | 2篇 |
1988年 | 5篇 |
1987年 | 4篇 |
1986年 | 2篇 |
1984年 | 1篇 |
1983年 | 2篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1977年 | 2篇 |
1974年 | 1篇 |
1972年 | 1篇 |
1968年 | 1篇 |
排序方式: 共有129条查询结果,搜索用时 343 毫秒
21.
22.
Scott D. Kuduk Ronald K. Chang Jenny M.-C. Wai Christina N. Di Marco Victoria Cofre Robert M. DiPardo Sean P. Cook Matthew J. Cato Aneta Jovanovska Mark O. Urban Michael Leitl Robert H. Spencer Stefanie A. Kane George D. Hartman Mark T. Bilodeau 《Bioorganic & medicinal chemistry letters》2009,19(15):4059-4063
A series of indole amidines modified at the 2-position of the indole ring were evaluated as inhibitors of Acid-Sensing Ion Channel-3 (ASIC3), a novel target for the treatment of chronic pain. 相似文献
23.
Scott D. Kuduk Christina N. Di Marco Ronald K. Chang Robert M. DiPardo Sean P. Cook Matthew J. Cato Aneta Jovanovska Mark O. Urban Michael Leitl Robert H. Spencer Stefanie A. Kane Mark T. Bilodeau George D. Hartman Mark G. Bock 《Bioorganic & medicinal chemistry letters》2009,19(9):2514-2518
A series of amiloride derivatives modified at the 5-position of the pyrazine ring were evaluated as inhibitors of acid-sensing ion channel-3 (ASIC3), a novel target for the treatment of chronic pain. 相似文献
24.
25.
26.
Mechanism of gene regulation by steroid hormones 总被引:5,自引:0,他引:5
27.
Polyacrylamide Slab Gel Electrophoresis of Soluble Proteins for Studies of Bacterial Floras 总被引:43,自引:9,他引:34 下载免费PDF全文
W. E. C. Moore D. E. Hash Lillian V. Holdeman Elizabeth P. Cato 《Applied microbiology》1980,39(4):900-907
A polyacrylamide slab gel electrophoresis procedure was used to compare cellular proteins from bacterial isolates of gingival crevice floras. Isolates with identical protein patterns consistently were shown to be members of the same species. When used to screen isolates, the procedure reduced total analytical time and expense without sacrificing accuracy, and it provided additional verification of the identity of strains characterized by conventional phenotypic tests. 相似文献
28.
29.
Progesterone induction of metallothionein-IIA gene expression 总被引:8,自引:0,他引:8
E P Slater A C Cato M Karin J D Baxter M Beato 《Molecular endocrinology (Baltimore, Md.)》1988,2(6):485-491
Expression of the metallothionein gene is known to be induced by glucocorticoids in a variety of cells. Here we show that in human cell lines containing functional progesterone receptors, the endogenous metallothionein-IIA (hMTIIA) gene is inducible by the synthetic progestins R5020 and medroxy-progesterone acetate. That this effect reflects a direct interaction with the metallothionein gene is supported by our finding that the partially purified progesterone receptor binds to the promoter region of the gene in vitro. The limits of the DNase I footprint and the guanine residues protected in methylation studies with the progesterone receptor are similar to those previously described for the glucocorticoid receptor. Thus, the hormone regulatory element of the human metallothionein-IIA gene can mediate regulation by both glucocorticoids and progestins, as does the hormone regulatory element of mouse mammary tumor virus. 相似文献
30.
Two groups of underwater vocalizations were identified in a three-year study of two captive leopard seals, Hydurga leptonyx (one female and one male at Taronga Zoo, Sydney). This was supplemented by recordings over three months from a male at Marineland, New Zealand. The sexual state of the seals at Taronga was deduced from serum hormonal concentrations: the female was considered to be in estrus at specific times during the breeding season. The seal at Marineland, New Zealand was assumed to be sexually mature on the basis of size and age. Of 12 different underwater sound types recorded, six were produced by the seals at Taronga Zoo during agonistic interactions (local calls) and were heard through most of the year. The other six sound types were produced by lone seals. These broadcast calls were produced by the female only when sexually receptive, and by the mature male during December and January, months believed to be the breeding season of wild leopard seals. We propose that underwater acoustic behavior is important in the mating system of this species, and that broadcast calls are used by mature females to advertise their sexual receptivity, and possibly by mature males in search of mates. 相似文献