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为筛选裸花紫珠治疗烧烫伤的活性部位,并初步研究其作用机制。实验采用90°C热水造成大鼠烫伤模型。以伤口面积大小,伤口性状,如颜色、软硬程度等为指标,通过宏观和微观检测筛选裸花紫珠治疗烧烫伤的活性部位。采用ELISA和Western blot等方法初步研究其作用机制。进入组织增生重塑期后,石油醚组相较其它各组,伤口愈合最为显著;在组织增生最后的成熟期,石油醚组的表皮和真皮恢复得最好,伤疤最小。石油醚组的VEGF浓度在早期出现了明显的上调;在第21天时,TGF-β1的表达水平最低。裸花紫珠治疗烧烫伤的活性部位初步推测在石油醚层,其治疗烧烫伤作用机制可能是早期裸花紫珠使VEGF上调,在后期下调了TGF-β1以达到。本研究为裸花紫珠治疗烧烫伤的进一步研究和应用提供依据。 相似文献
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云南植物三新种 总被引:1,自引:0,他引:1
<正> 马鞭草科 VERBENACEAE 紫珠属 CalliCarpa 细花紫珠 (江城紫珠) 新种 图1 Callicarpa minutiflora Y. Y. Qian, sp. nov. C. jiangchengensis Y. Y. Qian, ined. Species affinis C. acutifoliae H. T. Chang, sed foliis ellipticis, utrinque stellatopilosis, nervis lateralibus utrinseeus 7—9, cymis 4—6 cm latis, 5—7- 相似文献
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De-Wen Bi Ying-Xin Zhao Xiong Qiu Xue-Cong Zhang Ya-Ling Zhou Muhammad Aurang Zeb Wen-Hui Pang Rui Li Meng-Ru Wang Bin Cheng Jing-Jing Zhang Xing-Jie Zhang Xiao-Li Li Rui-Han Zhang Wei-Lie Xiao 《化学与生物多样性》2023,20(1):e202200985
Twelve new clerodane diterpenoids named callicarpanes A–L ( 1 – 12 ), together with eight known compounds ( 13 – 20 ), were isolated from Callicarpa integerrima. Their structures were determined by comprehensive spectroscopic data. The calculated chemical shifts were used to identify relative configurations using DP4+ analysis. The absolute configurations (AC) were assigned based on quantum chemical calculations and X-ray single-crystal diffraction methods. Compounds 1 , 3 , 5 , 9 , 10 , 12 , 15 , 16 , and 19 showed significant inhibitory activity for NLRP3 inflammasome activation, with the IC50 against lactate dehydrogenase (LDH) release ranging from 0.08 to 4.78 μM. Further study revealed that compound 10 repressed IL-1β secretion and caspase-1 maturation in J774A.1 cell as well as blocked macrophage pyroptosis. 相似文献