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101.
Zenchenko A. A. Drenichev M. S. Il’icheva I. A. Mikhailov S. N. 《Molecular Biology》2021,55(6):786-812
Molecular Biology - The emergence of new viruses and resistant strains of pathogenic microorganisms has become a powerful stimulus in the search for new drugs. Nucleosides are a promising class of... 相似文献
102.
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104.
O’Byrne Alice M. Lambourn Dyanna M. Rejmanek Daniel Haman Katherine O’Byrne Michael VanWormer Elizabeth Shapiro Karen 《EcoHealth》2021,18(1):84-94
EcoHealth - Increasing reports of marine mammal deaths have been attributed to the parasite Sarcocystis neurona. Infected opossums, the only known definitive hosts, shed S. neurona sporocysts in... 相似文献
105.
Khir Nurul Ajilah Mohamed Noh Ain’ Sabreena Mohd Shafin Nazlahshaniza Ismail Che Aishah Nazariah 《Purinergic signalling》2021,17(2):201-213
Purinergic Signalling - Pain is the most common symptom reported by patients with rheumatoid arthritis (RA) even after the resolution of chronic joint inflammation. It is believed that... 相似文献
106.
Drill Matthew Jones Nigel C. Hunn Martin O’Brien Terence J. Monif Mastura 《Purinergic signalling》2021,17(2):215-227
Purinergic Signalling - The P2X receptor 7 (P2X7R) is a plasma membrane receptor sensing extracellular ATP associated with a wide variety of cellular functions. It is most commonly expressed on... 相似文献
107.
D’Hont Anouk Gittenberger Adriaan Hendriks A. Jan Leuven Rob S. E. W. 《Biological invasions》2021,23(7):2125-2141
Biological Invasions - Ponto-Caspian dreissenids are notorious freshwater invaders. Recently, widespread observations show a dominance shift from the early invader, Dreissena polymorpha, to its... 相似文献
108.
Krauz V. I. Mitrofanov K. N. Myalton V. V. Il’ichev I. V. Kharrasov A. M. Vinogradova Yu. V. 《Plasma Physics Reports》2021,47(9):912-937
Plasma Physics Reports - The results of experiments on the study of the features of the dynamics and internal structure of the axial plasma ejection at the PF-3 facility carried out within the... 相似文献
109.
Chernikov I. V. Meschaninova M. I. Gladkikh D. V. Ven’yaminova A. G. Zenkova M. A. Vlassov V. V. Chernolovskaya E. L. 《Russian Journal of Bioorganic Chemistry》2021,47(2):399-410
Russian Journal of Bioorganic Chemistry - Delivery of siRNAs to blood cells is one of the most difficult tasks since there are no efficient and nontoxic methods of delivering nucleic acids to these... 相似文献
110.
Maria Davern Noel E. Donlon Andrew Sheppard Fiona O’ Connell Conall Hayes Anshul Bhardwaj Emma Foley Dermot O’ Toole Niamh Lynam-Lennon Narayanasamy Ravi John V. Reynolds Stephen G. Maher Joanne Lysaght 《Translational oncology》2021,14(6):101062
Use of immune checkpoint inhibitors (ICIs) with chemotherapy to enhance responses in oesophageal adenocarcinoma (OAC) is an attractive approach. We identified subpopulations of OAC cells expressing inhibitory immune checkpoint (IC) ligands (PD-L1, PD-L2 and CD160) and receptors (PD-1, TIGIT, TIM-3, LAG-3 and A2aR) in vitro and in ex vivo biopsies. Combination chemotherapy regimens FLOT and CROSS promote a more immune-resistant phenotype through upregulation of IC ligands and receptors on OAC cells in vitro. Importantly, this study investigated if OAC cells, enriched for ICs exhibited a more stem-like and senescent-like phentoype. FLOT preferentially upregulates PD-L1 on a stem-like OAC cell phenotype, defined by ALDH activity. Expression of senescence-associated β-galactosidase is induced in a subpopulation of OAC cells following FLOT and CROSS chemotherapy treatment, along with enhanced expression of TIM-3 and A2aR ICs. Blockade of PD-1 signalling in OAC cells induced apoptosis and enhanced FLOT and CROSS chemotherapy toxicity in vitro. Upregulation of ICs on OAC cells following chemotherapy may represent potential mechanisms of chemo-immune resistance. Combination ICIs may be required to enhance the efficacy of chemotherapy and immunotherapy in OAC patients. 相似文献