排序方式: 共有12条查询结果,搜索用时 15 毫秒
11.
Raju Dash Talha Bin Emran Mir Muhammad Nasir Uddin Ashekul Islam Md Junaid 《Bioinformation》2014,10(9):562-568
Alzheimer׳s disease (AD) is one of the most common dementias showing slow progressive cognitive decline. Progression of intracerebral
accumulation of beta amyloid (Aβ) peptides by the action of amyloid binding alcohol dehydrogenase (ABAD), a
mitochondrial enzyme and β-site amyloid precursor protein cleaving enzyme 1 (BACE1) and the degradation of
Acetylcholinesterase (AChE) the main pathological characteristics of AD. Therefore, it is of interest to evaluate the importance of
fisetin (a flavonol that belongs to the flavonoid group of polyphenols) binding with AChE, ABAD and BACE1 proteins. Docking
experiment of fisetin with these proteins using two different tools namely iGEMDOCK and FlexX show significant binding with
acceptable binding values. Thus, the potential inhibitory role of fisetin with AD associated proteins is documented. 相似文献
12.
Sery Gonedelé Bi Didier P Sokouri Kouakou Tiékoura Oulo Alla N?Nan Marcel Lolo Félix Gnangbé Assanvo SP N?Guetta 《Bioinformation》2014,10(11):671-678
Cête d׳Ivoire continues to have the highest HIV-1 prevalence rate in West Africa, although the infection number is in constant
decline. The external envelope protein of the viruses is a likely site of selection, and responsible for receptor binding and entry into
host cells, and therefore constitutes an ideal region with which to investigate the evolutionary processes acting on HIV-1. In this
study, we analyse 189 envelope glycoprotein V3 loop region sequences of viruse isolates from 1995 to 2009, from HIV-1 untreated
patients living in Cête d׳Ivoire, to decipher the temporal relationship between disease diversity, divergence and selection. Our
analyses show that the nonsynonymous and synonymous ratio (dN/dS) was lower than 1 for viral populations analysed within 15
years, which showed the sequences did not undergo adequate immune pressure. The phylogenetic tree of the sequences analysed
demonstrated distinctly long internal branches and short external branches, suggesting that only a small number of viruses
infected the new host cell at each transmission. In addition to identifying sites under purifying selection, we also identified neutral
sites that can cause false positive inference of selection. These sites presented form a resource for future studies of selection
pressures acting on HIV-1 enν gene in Cête d׳Ivoire and other West African countries. 相似文献