全文获取类型
收费全文 | 927篇 |
免费 | 70篇 |
国内免费 | 39篇 |
出版年
2023年 | 14篇 |
2022年 | 10篇 |
2021年 | 38篇 |
2020年 | 31篇 |
2019年 | 41篇 |
2018年 | 44篇 |
2017年 | 27篇 |
2016年 | 38篇 |
2015年 | 50篇 |
2014年 | 45篇 |
2013年 | 82篇 |
2012年 | 51篇 |
2011年 | 63篇 |
2010年 | 39篇 |
2009年 | 55篇 |
2008年 | 36篇 |
2007年 | 31篇 |
2006年 | 37篇 |
2005年 | 45篇 |
2004年 | 33篇 |
2003年 | 30篇 |
2002年 | 41篇 |
2001年 | 20篇 |
2000年 | 19篇 |
1999年 | 22篇 |
1998年 | 24篇 |
1997年 | 20篇 |
1996年 | 9篇 |
1995年 | 11篇 |
1994年 | 8篇 |
1993年 | 12篇 |
1992年 | 2篇 |
1991年 | 6篇 |
1990年 | 1篇 |
1989年 | 1篇 |
排序方式: 共有1036条查询结果,搜索用时 62 毫秒
991.
《Cell host & microbe》2020,27(1):129-139.e4
- Download : Download high-res image (151KB)
- Download : Download full-size image
992.
Anna Marouga Anastasia N. Kastania Christos Kroupis Maria Lagiou Koralia Saounatsou 《Biomarkers》2016,21(1):73-79
Context: Resistin is associated with inflammation, atherosclerosis and cardiovascular (CV) disease.Objective: To associate circulating resistin with all-cause and CV mortality in chronic kidney disease (CKD) patients.Methods: Serum resistin was determined in a cohort of 80 elderly, non-diabetic patients with stable CKD at different stages in a follow-up period of 5 years.Results: Circulating resistin was significantly elevated in deceased compared to alive patients. Resistin emerged as an independent biomarker of all-cause and CV mortality after a 5-year follow-up period.Conclusion: Elevated circulating resistin was a significant independent predictor of CV and all-cause mortality in elderly, non-diabetic CKD patients. 相似文献
993.
994.
995.
An understanding of the nature of the immune response to asexual erythrocytic stages of malaria parasites will facilitate vaccine development by identifying which responses the vaccine should preferentially induce. The present study examined and compared the immune responses of NIH mice in either single or mixed infections with avirulent (DK) or virulent (DS) strains of Plasmodium chabaudi adami using the ELISA test for detecting and measurement of cytokines and antibody production. In both single and mixed infections, the study showed that both cell- and antibody-mediated responses were activated. In all experiments, an early relatively high level of IFN-γ and IgG2a during the acute phase of the infection, and later elevation of IL-4 and IgG1, suggested that there was a sequential Th1/Th2 response. However, in the avirulent DK strain infection a stronger Th1 response was observed compared to the virulent DS strain-infection or in mixed infections. In the virulent DS infection, there was a stronger Th2 response compared to that in the DK and mixed infections. The faster proliferation rate of the virulent DS strain compared to the DK strain was also evident. 相似文献
996.
Negative regulatory proteins in a cytokine signaling play a critical role in restricting unwanted excess activation of the signaling pathway. At the same time, negative regulatory proteins need to be removed rapidly from cells to respond properly to the next incoming signal. A nuclear IκB protein called IκBNS is known to inhibit a subset of NF-κB target genes upon its expression by NF-κB activation. Here, we show a mechanism to control the stability of mIκBNS which might be important for cells to prepare the next round signaling. We found that mIκBNS is a short-lived protein of which the stability is controlled by proteasome, independent of ubiquitylation process. We identified that the N-terminal PEST sequence in mIκBNS was critical for the regulation of stability. 相似文献
997.
You-Lan Yang Hsin-Te Hsu Kuo-Hsien Wang Cheng-Ying Han Chien-Ming Chen Chi-Ming Chen Wun-Chang Ko 《Journal of biomedical science》2011,18(1):84
Background
Hesperetin was reported to selectively inhibit phosphodiesterase 4 (PDE4). While hesperetin-7,3'-O-dimethylether (HDME) is a synthetic liposoluble hesperetin. Therefore, we were interested in investigating its selectivity on PDE4 and binding ability on high-affinity rolipram-binding sites (HARBs) in vitro, and its effects on ovalbumin-induced airway hyperresponsiveness in vivo, and clarifying its potential for treating asthma and chronic obstructive pulmonary disease (COPD). 相似文献998.
《Cell host & microbe》2020,27(6):879-882.e2
- Download : Download high-res image (232KB)
- Download : Download full-size image
999.
1000.
Noriaki Kamio Sumio Akifusa Noboru Yamaguchi Kazuaki Nonaka & Yoshihisa Yamashita 《FEMS immunology and medical microbiology》2009,56(3):241-247
Adiponectin is an adipokine with potent anti-inflammatory properties. We previously reported that a globular adiponectin (gAd) suppresses Aggregatibacter actinomycetemcomitans lipopolysaccharide-induced nuclear factor-κB activity, suggesting an anti-inflammatory effect of gAd. In this study, we investigated whether gAd is able to modulate the effect of A. actinomycetemcomitans lipopolysaccharide on cytokine induction in a murine macrophage cell line (RAW 264). The phosphorylation of p38 mitogen-activated protein kinase, c-Jun N-terminal kinase, extracellular signal-regulated kinase, and IκB kinase α/β and the degradation of IκB, which were induced by A. actinomycetemcomitans lipopolysaccharide intoxication, were clearly reduced in gAd-pretreated RAW 264 cells compared with the untreated cells. Expression levels of tumor necrosis factor (TNF)-α and interleukin-10 (IL-10) mRNA were assessed by real-time PCR. Cell-free supernatants were collected after 12 h of stimulation and analyzed by enzyme-linked immunosorbent assay for TNF-α and IL-10. Pretreatment with gAd significantly inhibited the A. actinomycetemcomitans lipopolysaccharide-induced TNF-α mRNA expression and protein secretion. In contrast, pretreatment with gAd significantly enhanced the A. actinomycetemcomitans lipopolysaccharide-induced IL-10 mRNA expression and protein secretion. These data suggest a mechanism for the anti-inflammatory activity of gAd in local inflammatory lesions, such as periodontitis. 相似文献