排序方式: 共有70条查询结果,搜索用时 31 毫秒
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肾缺血再灌流损伤过程中肾小管上皮细胞色素氧化酶活性变化及TAD防治作用的研究 总被引:1,自引:0,他引:1
本实验选用大鼠一侧肾切除,对侧肾缺血60min动物模型,用组织化学方法观察再灌流15min,24h髓质外带肾小管上皮细胞色素氧化酶活性的变化及还原型谷胱甘肽(TAD)对它们的影响。结果发现60min肾缺血后再灌流可致细胞色素氧化酶活性呈进行性降低。给TAD能一定程度地保护细胞色素氧化酶活性。提示氧自由基可能损害细胞色素氧化酶活性,细胞色素氧化酶活性降低在肾缺血再灌流损伤中可能起重要作用。 相似文献
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In eukaryotes, the genome is hierarchically packed inside the nucleus, which facilitates physical contact between cis-regulatory elements (CREs), such as enhancers and promoters. Accumulating evidence highlights the critical role of higher-order chromatin structure in precise regulation of spatiotemporal gene expression under diverse biological contexts including lineage commitment and cell activation by external stimulus. Genomics and imaging-based technologies, such as Hi-C and DNA fluorescence in situ hybridization (FISH), have revealed the key principles of genome folding, while newly developed tools focus on improvement in resolution, throughput and modality at single-cell and population levels, and challenge the knowledge obtained through conventional approaches. In this review, we discuss recent advances in our understanding of principles of higher-order chromosome conformation and technologies to investigate 4D chromatin interactions. 相似文献
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《Cell》2023,186(18):3826-3844.e26