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Andrea Barbieri Barros Alex Miranda Rodrigues Mariane Pereira Batista Sidney Munhoz Junior Marcia Hueb Cor Jesus Fontes 《Memórias do Instituto Oswaldo Cruz》2014,109(4):499-501
Antimony compounds are the cornerstone treatments for tegumentary leishmaniasis. The
reactivation of herpes virus is a side effect described in few reports. We conducted
an observational study to describe the incidence of herpes zoster reactivation during
treatment with antimony compounds. The global incidence of herpes zoster is
approximately 2.5 cases per 1,000 persons per month (or 30 cases per 1,000 persons
per year). The estimated incidence of herpes zoster in patients undergoing antimony
therapy is higher than previously reported. 相似文献
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Insaf Salem Fourati Anne-Julie Grenier élyse Jolette Natacha Merindol Philippe Ovetchkine Hugo Soudeyns 《Journal of visualized experiments : JoVE》2014,(89)
Varicella zoster virus (VZV) is a significant cause of morbidity and mortality following umbilical cord blood transplantation (UCBT). For this reason, antiherpetic prophylaxis is administrated systematically to pediatric UCBT recipients to prevent complications associated with VZV infection, but there is no strong, evidence based consensus that defines its optimal duration. Because T cell mediated immunity is responsible for the control of VZV infection, assessing the reconstitution of VZV specific T cell responses following UCBT could provide indications as to whether prophylaxis should be maintained or can be discontinued. To this end, a VZV specific gamma interferon (IFN-γ) enzyme-linked immunospot (ELISpot) assay was developed to characterize IFN-γ production by T lymphocytes in response to in vitro stimulation with irradiated live attenuated VZV vaccine. This assay provides a rapid, reproducible and sensitive measurement of VZV specific cell mediated immunity suitable for monitoring the reconstitution of VZV specific immunity in a clinical setting and assessing immune responsiveness to VZV antigens. 相似文献
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