曲美他嗪联合麝香保心丸治疗急性心肌梗死的效果研究

目的:研究曲美他嗪(TMZ)联合麝香保心丸(HMP)治疗急性心肌梗死的效果。方法:采用40只雄性C57BL/6J小鼠构建急性心肌梗死模型,随机分成4组,每组10只:(1)假手术组;(2)心肌梗死组;(3)心肌梗死+TMZ组(TMZ 20 mg/Kg灌胃,3次/天);(4)心肌梗死+TMZ+HMP组(HMP 14 mg/Kg灌胃,3次/天)。2周后行心脏超声检查采集心功能参数左室舒张末内径、左室收缩末内径、室间隔厚度、舒张末期左室后壁厚度及射血分数。同时,对心脏标本行形态学分析。结果:TMZ+HMP组左室舒张末内径、左室收缩末内径、舒张末期左室后壁厚度及射血分数均优于于TMZ组(均为P0.05)。心肌组织HE及PSR染色显示TMZ+HMP组心肌细胞坏死及纤维化程度较其余组低。结论:曲美他嗪联合麝香保心丸治疗急性心肌梗死的效果较单用曲美他嗪更加显著。     

Validity and Reliability of the CorTempTM Telemetric Pill during 50 h of Reuse in a Circulating Water Bath

It has been shown that CorTemp^TM telemetric pills (CTTPs) provide valid measures of rectal temperature when used as suppositories. While encapsulated into a condom linked to a thread, CTTPs can be inserted in and extracted from the rectum and be reused. The validity and reliability of the CTTP throughout repeated use remains to be demonstrated. Three CTTPs were compared to a YSI 401 wired rectal probe inside a circulating water bath (temperatures varying from 36.5 to 39.4 °C) during 50 h of intermittent use. Each CTTP underwent 20 trials comprising 6 protocols of varying duration: 6 · 1 h, 5 · 2 h, 4 · 3 h, 3 · 4 h and 2 · 5 h. All CTTPs were washed, switched off and disinfected after each trial to reproduce real-life use. Acceptable agreement between sensors was taken as a mean bias within ±0.27 °C. None of the pills showed signs of deterioration following 50 h of reuse. As for relative validity, where all CTTPs showed robust coefficients of determination ranging from 0.98 to 0.99, absolute validity was excellent with each CTTP showing mean biases and typical errors of the estimate (TEE) within ±0.27 °C. Comparisons between the first and last trial each CTTP underwent resulted in means biases and TEEs within ±0.27 °C and coefficients of determination ranging from 0.97 to 0.99, which indicates strong absolute and relative reliability. The present results show that CTTPs can provide valid and reliable measurements of temperature when reused up to 50 h.