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11.
Acidification inside membrane compartments is a common feature of all eukaryotic cells. The acidic milieu is involved in many
physiological processes including secretion, protein processing, and others. However, its cellular relevance has not been
well established beyond the results of in vitro studies involving cultured cell systems. In the last decade, human and mouse
genetics have revealed that the acidification machinery is implicated in multiple pathophysiological disorders, and thus our
understanding of physiological consequences of the defective acidification in multicellular organisms has improved. In invertebrates
including Drosophila and nematodes, mutations of V-ATPase were found to lead the development of rather unexpected phenotypes. Studies have suggested
that V-ATPase may be involved in membrane fusion and vesicle formation, important processes for membrane trafficking, and
have further implied its involvement in cell–cell fusion. This rather novel idea arose from the phenotypes associated with
genetic disorders involving V-ATPase genes in various genetic model systems. In this article, we focus and overview the non-classical,
beyond proton-pumping function of the vacuolar-type ATPase in exo/endocytic systems. 相似文献
12.
Effect of a meal feeding schedule on hepatic glycogen synthesis and gluconeogenesis in rats 总被引:1,自引:0,他引:1
We investigated the effect of a meal feeding schedule (MFS) on food intake, hepatic glycogen synthesis, hepatic capacity to produce glucose and glycemia in rats. The MFS comprised free access to food for a 2-hour period daily at a fixed mealtime (8.00-10.00 a.m.) for 13 days. The control group was composed of rats with free access to food from day 1 to 12, which were then starved for 22 h, refed with a single meal at 8.00-10.00 a.m. and starved again for another 22 h. All experiments were performed at the meal time (i.e. 8.00 a.m.). The MFS group exhibited increased food intake and higher glycogen synthase activity. Since gluconeogenesis from L-glutamine or L-alanine was not affected by MFS, we conclude that the increased food intake and higher glycogen synthase activity contributed to the better glucose maintenance showed by MFS rats at the fixed meal time. 相似文献