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20世纪90年代初,自美国率先提出并实施“脑的十年”国家科技发展的宏伟蓝图,随即欧共体成立了“欧洲脑的十年”委员会,日本也全面启动了庞大的“脑科学时代”国家科研计划,标志着人类推进文明社会的塑造和活力科技的发展已步入到探索脑奥秘的时代引领特征。扼要诠释脑科学的内涵——这一新时代重大科学前沿探索项目的战略目标：阐明智力与思维的脑机制“理解脑”;延缓衰老和治疗神经性和精神性疾病“保护脑”;发展脑风格的人工智能和神经计算系统“创造脑”。 相似文献
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The henipaviruses, represented by Nipah virus and Hendra virus, are emerging zoonotic viral pathogens responsible for repeated outbreaks associated with high morbidity and mortality in Australia, Southeast Asia, India and Bangladesh. These viruses enter host cells via a class I viral fusion mechanism mediated by their attachment and fusion envelope glycoproteins; efficient membrane fusion requires both these glycoproteins in conjunction with specific virus receptors present on susceptible host cells. The henipavirus attachment glycoprotein interacts with a cellular B class ephrin protein receptor triggering conformational alterations leading to the activation of the viral fusion (F) glycoprotein. The analysis of monoclonal antibody (mAb) reactivity with G has revealed measurable alterations in the antigenic structure of the glycoprotein following its binding interaction with receptor. These observations only appear to occur with full-length native G glycoprotein, which is a tetrameric oligomer, and not with soluble forms of G (sG), which are disulfide-linked dimers. Single amino acid mutations in a heptad repeat-like structure within the stalk domain of G can disrupt its association with F and subsequent membrane fusion promotion activity. Notably, these mutants of G also appear to confer a postreceptor bound conformation implicating the stalk domain as an important element in the G glycoprotein's structure and functional relationship with F. Together, these observations suggest fusion is dependent on a specific interaction between the F and G glycoproteins of the henipaviruses. Further, receptor binding induces measurable changes in the G glycoprotein that appear to be greatest in respect to the interactions between the pairs of dimers comprising its native tetrameric structure. These receptor-induced conformational changes may be associated with the G glycoprotein's promotion of the fusion activity of F. 相似文献
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在建设项目竣工阶段,环保验收工作的具体内容就是针对环境保护设施的管理、运行以及效果与污染排放等情况进行全面的检查与测试。本文就针对建设项目竣工环保验收监测工作展开讨论,阐述具体的工作程序,分析整个过程中的重点内容。 相似文献
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