排序方式: 共有44条查询结果,搜索用时 0 毫秒
41.
R. W. Roudijk K. Taha M. Bourfiss P. Loh L. van den Heuvel M. J. Boonstra F. van Lint S. M. van der Voorn A. S. J. M. te Riele L. P. Bosman I. Christiaans T. A. B. van Veen C. A. Remme M. P. van den Berg J. P. van Tintelen F. W. Asselbergs 《Netherlands heart journal》2021,29(6):301
In relatives of index patients with dilated cardiomyopathy and arrhythmogenic cardiomyopathy, early detection of disease onset is essential to prevent sudden cardiac death and facilitate early treatment of heart failure. However, the optimal screening interval and combination of diagnostic techniques are unknown. The clinical course of disease in index patients and their relatives is variable due to incomplete and age-dependent penetrance. Several biomarkers, electrocardiographic and imaging (echocardiographic deformation imaging and cardiac magnetic resonance imaging) techniques are promising non-invasive methods for detection of subclinical cardiomyopathy. However, these techniques need optimisation and integration into clinical practice. Furthermore, determining the optimal interval and intensity of cascade screening may require a personalised approach. To address this, the CVON-eDETECT (early detection of disease in cardiomyopathy mutation carriers) consortium aims to integrate electronic health record data from long-term follow-up, diagnostic data sets, tissue and plasma samples in a multidisciplinary biobank environment to provide personalised risk stratification for heart failure and sudden cardiac death. Adequate risk stratification may lead to personalised screening, treatment and optimal timing of implantable cardioverter defibrillator implantation. In this article, we describe non-invasive diagnostic techniques used for detection of subclinical disease in relatives of index patients with dilated cardiomyopathy and arrhythmogenic cardiomyopathy. 相似文献
42.
We studied two statistical hypotheses for the occurrence of cellular division and compared these hypotheses to available
data. The two models were tested by observed distributions of cellular size during steady-state growth. The 30-year-old sloppy
size model could be rejected, whereas the recently developed incremental size proposal could not. The latter proposition was
accepted by default. We concluded that the time between successive divisions is not simply derived from extant size at cellular
division, but rather from interdivisional size increment. We therefore propose that cellular division is regulated by the
need of cells at birth to accumulate a certain amount of mass or something related to mass before division.
Received: 22 December 1996 / Accepted: 6 August 1997 相似文献
43.
Patrícia IS Pinto Pratap B Singh João B Condeça Helena R Teodósio Deborah M Power Adelino VM Canário 《Reproductive biology and endocrinology : RB&E》2006,4(1):67-11
Background
ICI 182,780 (ICI) belongs to a new class of antiestrogens developed to be pure estrogen antagonists and, in addition to its therapeutic use, it has been used to knock-out estrogen and estrogen receptor (ER) actions in several mammalian species. In the present study, the effects and mechanism of action of ICI were investigated in the teleost fish, sea bream (Sparus auratus). 相似文献44.
Eduardo N Barata Peter C Hubbard Olinda G Almeida António Miranda Adelino VM Canário 《BMC biology》2007,5(1):54