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301.
Stylianos Mamatas-Kalamaras Thierry Sévenet Claude Thal Pierre Potier 《Phytochemistry》1975,14(8):1849-1854
Eleven alkaloids have been isolated from Alstonia quaternata. Three of them, namely 11-methoxy-epi-3α-yohimbine, 10,11-dimethoxy-picrinine designated quaternine, and 19,20-epoxy-N(a)-methyl, desacetyl, desformo, 2βH-dihydroakuammiline designated quaternoxine, are new alkaloids. 相似文献
302.
Henning Gruell Stylianos Bournazos Jeffrey V. Ravetch Alexander Ploss Michel C. Nussenzweig John Pietzsch 《Journal of virology》2013,87(15):8535-8544
The development of an effective vaccine preventing HIV-1 infection remains elusive. Thus, the development of novel approaches capable of preventing HIV-1 transmission is of paramount importance. However, this is partly hindered by the lack of an easily accessible small-animal model to rapidly measure viral entry. Here, we report the generation of a human CD4- and human CCR5-expressing transgenic luciferase reporter mouse that facilitates measurement of peritoneal and genitomucosal HIV-1 pseudovirus entry in vivo. We show that antibodies and antiretrovirals mediate preexposure protection in this mouse model and that the serum antibody concentration required for protection from cervicovaginal infection is comparable to that required to protect macaques. Our results suggest that this system represents a model for the preclinical evaluation of prophylactic or vaccine candidates. It further supports the idea that broadly neutralizing antibodies should be evaluated for use as preexposure prophylaxis in clinical trials. 相似文献
303.
YAC and cosmid FISH mapping of an unbalanced chromosomal translocation causing partial trisomy 21 and Down syndrome 总被引:3,自引:0,他引:3
M. Nadal M. Milà Melanie Pritchard Antonio Mur Josep Pujals Jean-Louis Blouin Stylianos E. Antonarakis Francesca Ballesta X. Estivill 《Human genetics》1996,98(4):460-466
Most cases of Down syndrome (DS) result from a supernumerary chromosome 21; however, there are rare cases in which DS is
due to partial trisomy of chromosome 21, involving various segments of the chromosome. The characterization of cases of DS
that are due to partial trisomy 21 allows the phenotype to be correlated with the genotype. We present a case with features
of DS and a partial trisomy of chromosome 21 inherited from a paternal balanced translocation involving chromosomes 13 and
21. Fluorescence in situ hybridization analysis using yeast artificial chromosome (YAC) probes mapped the breakpoint to 21q22.1,
within YAC 230E8, which contains markers CBR, D21S333 and D21S334. Further mapping using cosmids positioned the breakpoint
proximal to CBR. The patient was also monosomic for the distal portion of chromosome 13 (q33–qter). Many phenotypic features
of DS were present including hypotonia, flat occiput, flat facies, up-slanted palpebral fissures, epicanthic folds, flat nasal
bridge, macroglossia, open mouth, small ears and a heart murmur. This case further supports the contention that the majority
of the phenotypic features of DS map to 21q22–qter and further refines the location of some of them. In addition to the DS
phenotype, the patient had a prominent upper maxilla with protruding upper incisors, and low levels of the coagulation factors
VII and X, consistent with a syndrome resulting from monosomy 13q33–qter. Since some features overlap between the two syndromes,
including severe mental retardation, it is unclear to what extent monosmy for 13q33–qter, trisomy for 21q22.1–qter, or a combination
of both, contributed to the common features of the phenotype.
Received: 27 March 1996 / Revised: 15 May 1996 相似文献
304.