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221.
Tetsuhiro Niidome Yasuaki Goto Masaru Kato Saori Goh Akinori Akaike Hachiro Sugimoto 《Biochemical and biophysical research communications》2009,386(4):734-738
Amyloid-β peptide (Aβ) is thought to be linked to the pathogenesis of Alzheimer’s disease. Recent studies suggest that Aβ has important physiological roles in addition to its pathological roles. We recently demonstrated that Aβ42 protects hippocampal neurons from glutamate-induced neurotoxicity, but the relationship between Aβ42 assemblies and their neuroprotective effects remains largely unknown. In this study, we prepared non-fibrillar and fibrillar Aβ42 based on the results of the thioflavin T assay, Western blot analysis, and atomic force microscopy, and examined the effects of non-fibrillar and fibrillar Aβ42 on glutamate-induced neurotoxicity. Non-fibrillar Aβ42, but not fibrillar Aβ42, protected hippocampal neurons from glutamate-induced neurotoxicity. Furthermore, non-fibrillar Aβ42 decreased both neurotoxicity and increases in the intracellular Ca2+ concentration induced by N-methyl-d-aspartate (NMDA), but not by α-amino-3-hydrozy-5-methyl-4-isoxazole propionic acid (AMPA). Our results suggest that non-fibrillar Aβ42 protects hippocampal neurons from glutamate-induced neurotoxicity through regulation of the NMDA receptor. 相似文献
222.
Ecosystems - Silicon is an essential or beneficial element in many organisms. Silicon uptake by vegetation strongly influences terrestrial silicon dynamics; however, little is known about the... 相似文献
223.
224.
Yoshiyuki Ono Akira Kawase Hiroyoshi Watanabe Ayako Shiraishi Satoshi Takeda Yoshinobu Higuchi Katsuhiko Sato Tsuyoshi Yamauchi Tetsuhiro Mikami Masahiro Kato Naoko Tsugawa Toshio Okano Noboru Kubodera 《Bioorganic & medicinal chemistry》1998,6(12):2517-2523
Analogues related to 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (ED-71) (2), 26,27-dimethyl ED-71 (3) and 26,27-diethyl ED-71 (4), were synthesized from lithocholic acid (5). In the study of the preventive effects of these analogues and ED-71 (2) on bone mineral loss in ovariectomized rats, 26,27-dimethyl ED-71 (3) showed the most potent activity. 相似文献