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Faisal Thayyullathil Shahanas Chathoth Jaleel Kizhakkayil Alaa Galadari Abdulkader Hago Mahendra Patel Sehamuddin Galadari 《Biochemical and biophysical research communications》2011,(1):1
Glutathione (GSH) is the most abundant non-protein antioxidant in mammalian cells. It has been implicated in playing an important role in different signal transduction pathways, and its depletion is an early hallmark in the progression of apoptosis in response to a number of proapoptotic stimuli. We have selectively investigated the role of GSH in cytotoxic response of Jurkat and Molt-4 human leukemic cells to the anti-cancer drug Doxorubicin. In this study, we have shown that extracellular supplementation of GSH to human leukemic cells renders them a resistant phenotype to Doxorubicin treatment. Glutathione pre-treatment inhibits Doxorubicin-induced p53Ser15 phosphorylation, caspase dependent ceramide (Cer) generation, Poly (ADP-ribose) polymerase (PARP) cleavage, and DNA fragmentation. Taken together, these results indicate that the major cellular antioxidant GSH influences the chemotherapeutic efficacy of Doxorubicin towards human leukemic cells. 相似文献
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Irradiation stress adversely affects plant growth and development. The radio protective activity by glycinebetaine in plants
has not been reported, and its mechanism has not been known. Gamma rays at doses 0.0, 25, 50, 100, and 150 Gray (Gy) when
applied pre-sowingly to dry seeds of fenugreek from a cobalt source (60Co) with strength of 500 Ci and the dose rate of 0.54 Gy/min significantly reduced chlorophyll content, total protein, photosynthetic
efficiency (14CO2-fixation), total dry weight, the accumulation of reducing, non-reducing and total soluble sugars in comparison with un-irradiated
control. It also significantly repressed the activities of hydrolytic enzymes (α-amylase and invertase), the carboxylating
enzyme (ribulose-1,5-bisphosphate-carboxylase/oxygenase) in the developed fenugreek plants. Soaking irradiated seeds with
glycinebetaine (50 mM) for 24 h partially alleviated the depression effects of irradiation in these parameters. γ-irradiation
treatment increased significantly H2O2 content. Presoaking irradiated seeds with GB decreased significantly the H2O2 level. The magnitude of the reversal decreased with increasing the irradiation dose. γ-irradiation induced a significant
decrease in the level of nucleic acids (DNA and RNA) accompanied by a corresponding induction of hydrolytic activities of
DNase and RNase in the developed plants in comparison with un-irradiated control. Those changes were more significant at higher
γ-ray doses. Post-treatment of irradiated seeds with GB partially alleviated the adverse effects of radiation. It significantly
increased nucleic acid levels and repressed the activities of DNase and RNase. The protective role played by glycinebetaine
was more significant at lower γ-ray doses. Pretreatment of seeds with GB may play an effective role in the radio-repair mechanism. 相似文献
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Akeel Arshiya Khan M. Masroor Akhtar Jaleel Hassan Uddin Moin 《Journal of Plant Growth Regulation》2020,39(2):955-955
Journal of Plant Growth Regulation - The original version of this article unfortunately contained a mistake in Table 3. The correct Table is given below. 相似文献
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Triadimefon (TDM), a systemic fungicide with non-traditional plant-growth regulator properties, was administered to Catharanthus roseus (L.) G. Don. plants in order to determine its effects on oxidative injury in terms of H2O2 content, lipid peroxidation (LPO), electrolyte leakage (EL), protein and amino acid contents, as well as proline metabolism. The LPO, estimated as thiobarbituric acid-reactive substances (TBARS), decreased under TDM treatment. It was found that H2O2 and EL were reduced under TDM treatment when compared to control. TDM treatment caused a significant increase in the protein and amino acid contents. Glycine betaine (GB) and proline (PRO) significantly accumulated in C. roseus under stress arisen from fungicide applications. Proline oxidase (PROX) activities reduce the PRO content and gamma-glutamyl kinase (gamma-GK) accelerates the synthesis of PRO. Under TDM treatment, the activity of PROX decreased and the gamma-GK activity increased. From our results, it is suggested that fungicide triadimefon causes activation of metabolic processes in the medicinal plant Catharanthus roseus. These findings are of great significance for the cultivation of this medicinal plant, as it was previously reported that TDM causes an enhancement of antioxidant metabolism and ajmalicine production in C. roseus. 相似文献
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A pot-culture experiment was conducted to estimate the ameliorating effect of triadimefon (TDM) on drought stress in sunflower (Helianthus annuus L.) plants. The plants were subjected to 3-, 6-, and 9-day-interval drought (DID) stress and drought stress with TDM @ 15 mg l(-1) and 15 mg l(-1) TDM alone from the 30th day after sowing (DAS). One-day-interval irrigation was kept as control. The plant samples were collected on and separated into root, stem and leaf for estimating the amino acid (AA), proline (PRO) and glycine betaine (GB) contents and the activities of antioxidant enzymes. Individual and combined drought stress and TDM treatments increased AA, PRO and GB contents, superoxide dismutase (SOD), ascorbate peroxidase (APX), catalase (CAT), and polyphenol oxidase (PPO) activities when compared to control. From the results of this investigation, it can be concluded that the application of TDM caused a partial amelioration of the adverse effects of drought stress by its influence on quaternary ammonium compounds and antioxidant potentials in H. annuus plants. 相似文献
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Aiswarya Gopal Usha Vaikom Parameswaran Koovapurath Useph Abdul Jaleel Narayanane Saravanane 《Marine Biology Research》2020,16(2):134-140
ABSTRACTA new species of polychaete, Prionospio atrovitta, is described from the sandy sediments of the Andaman and Nicobar insular margin. The major feature distinguishing P. atrovitta from other species of the genus Prionospio is the presence of well-marked black pigmented band near the anterior dorsal margin of the prostomium and pigmentation on the caruncle in the adults. 相似文献