全文获取类型
收费全文 | 490篇 |
免费 | 32篇 |
国内免费 | 1篇 |
出版年
2023年 | 1篇 |
2022年 | 1篇 |
2021年 | 11篇 |
2020年 | 3篇 |
2019年 | 5篇 |
2018年 | 7篇 |
2017年 | 5篇 |
2016年 | 6篇 |
2015年 | 25篇 |
2014年 | 35篇 |
2013年 | 20篇 |
2012年 | 40篇 |
2011年 | 45篇 |
2010年 | 34篇 |
2009年 | 32篇 |
2008年 | 42篇 |
2007年 | 38篇 |
2006年 | 38篇 |
2005年 | 28篇 |
2004年 | 23篇 |
2003年 | 15篇 |
2002年 | 20篇 |
2001年 | 4篇 |
2000年 | 3篇 |
1999年 | 4篇 |
1998年 | 2篇 |
1997年 | 5篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1994年 | 4篇 |
1993年 | 1篇 |
1992年 | 1篇 |
1990年 | 3篇 |
1989年 | 4篇 |
1988年 | 1篇 |
1986年 | 1篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 3篇 |
1981年 | 1篇 |
1979年 | 3篇 |
1974年 | 2篇 |
1972年 | 1篇 |
排序方式: 共有523条查询结果,搜索用时 78 毫秒
521.
Jeffrey R. Cottrell Bing Li Jae Won Kyung Crystle J. Ashford James J. Mann Tamas L. Horvath Timothy A. Ryan Sung Hyun Kim David J. Gerber 《The Journal of biological chemistry》2016,291(4):1948-1956
Variation in PPP3CC, the gene that encodes the γ isoform of the calcineurin catalytic subunit, has been reported to be associated with schizophrenia. Because of its low expression level in most tissues, there has been little research devoted to the specific function of the calcineurin Aγ (CNAγ) versus the calcineurin Aα (CNAα) and calcineurin Aβ (CNAβ) catalytic isoforms. Consequently, we have a limited understanding of the role of altered CNAγ function in psychiatric disease. In this study, we demonstrate that CNAγ is present in the rodent and human brain and dephosphorylates a presynaptic substrate of calcineurin. Through a combination of immunocytochemistry and immuno-EM, we further show that CNAγ is localized to presynaptic terminals in hippocampal neurons. Critically, we demonstrate that RNAi-mediated knockdown of CNAγ leads to a disruption of synaptic vesicle cycling in cultured rat hippocampal neurons. These data indicate that CNAγ regulates a critical aspect of synaptic vesicle cycling and suggest that variation in PPP3CC may contribute to psychiatric disease by altering presynaptic function. 相似文献
522.
Britta Hedlund Harald Norin † Alex Christakopoulos † Peteris Alberts ‡ Tamas Bartfai 《Journal of neurochemistry》1982,39(3):871-873
Abstract: The pharmacological properties of acetylarsenocholine, an arsenic analogue of acetylcholine, were investigated. Acetylarsenocholine behaved as a cholinergic ligand both in the central and peripheral nervous system. It bound to nicotinic receptors in rat medulla-pons with a K D of 15 μ M and to muscarinic receptors in rat cerebral cortex with a K D of 10 μ M . It behaved also as an agonist at presynaptic muscarinic receptors in guinea pig ileum myenteric plexus preparation. Arsenocholine is an alternative substrate for choline acetyltransferase and acetylarsenocholine is an alternative substrate for acetylcholinesterase. 相似文献
523.
Predator exclosure cages are designed to increase the clutch survival of ground‐nesting birds. Predator exclosures provided for the endangered St. Helena Plover Charadrius sanctaehelenae, however, did not result in differences in clutch survival between protected and control nests and may have resulted in elevated adult mortality. Exclosures did not exclude all cats, the dominant nest predator, and it is likely that cats caused the adult mortalities observed close to the exclosures. A population model indicates that even if predator exclosures had excluded all cats, the benefits of increased clutch survival would have been more than negated by the estimated decrease in adult survival. The overall effect of predator exclosures needs to be clarified for other species, taking into consideration annual productivity and adult survival, to understand the circumstances in which predator exclosures are beneficial. 相似文献