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Takuya Suzuki Kikuji Itoh Takehiro Hagiwara Hiroyuki Nakayama Kazuhito Honjyo Yoshikazu Hirota Tsutomu Kaneko Hideki Suzuki 《Current microbiology》1996,33(2):78-83
Effects of intraperitoneal injection of cyclophosphamide, an immunosuppressant, on the degree of bacterial translocation
and morphological changes of Peyer's patches (PP) in the intestine were investigated with antibiotic-decontaminated SPF mice
and germfree mice monoassociated with Escherichia coli C25. It has been reported that treatment with cyclophosphamide induces bacterial translocation. Cyclophosphamide treatment
in this study, however, significantly decreased E. coli C25 translocation from the gastrointestinal tract to the mesenteric lymph nodes (MLN), although the numbers of lymphoid cells,
especially B cells, in the PP, MLN, and spleen were remarkably reduced. Four injections of cyclophosphamide at a dose of 100
mg/kg inhibited bacterial translocation more than one injection at a dose of 200 mg/kg in SPF mice. Germfree mice, however,
treated with one dose of 200 mg/kg showed the same inhibition of bacterial translocation as those given 100 mg/kg four times.
In cyclophosphamide-treated mice, lymph follicles in the PP were obviously smaller than those in control mice, M-cells were
similar in appearance to absorption epithelial cells except for short microvilli, and immune cells among the M-cells had disappeared.
These data suggested that inhibition of bacterial translocation in mice treated with cyclophosphamide may be the result of
morphological and physiological changes of epithelial cells in the gastrointestinal tract, especially M-cells, as a point
of entry of invading bacteria, independent of the changes in immunological function.
Received: 16 November 1995 / Accepted: 12 December 1995 相似文献
606.
Masahiro Nakaoka Norihiko Ito Tomoko Yamamoto Takehiro Okuda Takashi Noda 《Ecological Research》2006,21(3):425-435
Factors and processes affecting community structures operate at various spatial and temporal scales. We analyzed how similarities
of rocky intertidal assemblages vary at different spatial scales using a nested, hierarchical sampling design. Intertidal
assemblages consisting of algae, sessile animals, and mobile animals were censused on five rock walls at each of five shores
chosen within each of six regions along the Pacific coast of Japan, encompassing 1,800 km of coastlines. Based on this sampling
design, similarities in assemblages were calculated using both qualitative (presence/absence) and quantitative (percent cover
and density) data, and compared at three spatial levels: (1) rock level (the finest spatial scale, encompassing several to
hundreds of meters), (2) shore level (the intermediate spatial scale, encompassing several to tens of kilometers), and (3)
region level (the broadest spatial scale, encompassing hundreds to thousands of kilometers). Cluster analysis showed that
assemblages were categorized into distinct regional groups except for the two southern regions, but they did not separate
clearly from each shore. A nested analysis of similarities revealed significant variation in similarities among regions and
among shores within each region, with the former showing greater variation. Similarity was negatively correlated with geographic
distance at the regional level but not at the shore or the rock levels. At the regional level, similarity decreased more rapidly
with distance for mobile animals than sessile organisms. The analyses highlighted the importance of broad-scale abiotic/biotic
factors such as oceanic current conditions and biogeographic factors in determining observed patterns in similarity of rocky
intertidal assemblages. 相似文献
607.
To compare the nutrient economy of woody plants at timberline of Mt. Fuji, seasonal changes in nitrogen content in leaves
were examined. There was remarkable difference in seasonal changes in leaf nitrogen content betweenAlnus maximowiczii and other deciduous trees at same habitat.A. maximowiczii scarcely withdrew the leaf nitrogen to woody part during the shedding period, while the other species withdrew about half
of the leaf nitrogen to woody part. 相似文献
608.
Angioarchitecture of primary oral malignant melanomas. 总被引:6,自引:0,他引:6
You-Jin Lee Noriyuki Nagai Chong-Huat Siar Keisuke Nakano Hitoshi Nagatsuka Hidetsugu Tsujigiwa Cheng-Hsiung Roan Mehmet Gunduz 《The journal of histochemistry and cytochemistry》2002,50(11):1555-1562
Angiogenesis is an essential process in the progression of malignant tumors. However, little is known of the angioarchitecture in primary oral malignant melanoma. We sought to determine this by the use of periodic acid-Schiff (PAS) stain, endothelial markers (CD34, CD105) and laminin, and by transmission electron microscopy in two cases. The results demonstrated that endothelium-lined vessels dominated the tumor microvasculature and these stained positively for PAS, laminin, and endothelial markers. Mosaic and tumor-lined vessels were infrequently encountered. Most PAS-positive patterned networks and loops ultrastructurally represented intratumor microhemorrhages that probably arose secondary to tumor vessel leakiness. Vascular channels of the vasculogenic mimicry type were rare. They stained for laminin but not for endothelial markers. 相似文献