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121.
Overexpression of the class I homeodomain transcription factor TaHDZipI‐5 increases drought and frost tolerance in transgenic wheat 下载免费PDF全文
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Rajeev Kumar Pandey Minu Bajpai Abid Ali Sukanya Gayan Amit Singh 《Indian journal of human genetics》2013,19(4):449-453
OBJECTIVE:
The Objective of this study was to identify the association of mutation of fibroblast growth factor receptor 1 (FGFR1), FGFR2 genes with syndromic as well as non-syndromic craniosynostosis in Indian population.MATERIALS AND METHODS:
Retrospective analysis of our records from January 2008 to December 2012 was done. A total of 41 cases satisfying the inclusion criteria and 51 controls were taken for the study. A total volume of 3 ml blood from the patient as well as parents was taken. Deoxyribonucleic acid extracted using phenol chloroform extraction method followed by polymerase chain reaction-restriction fragment length polymorphism method.RESULTS:
There were 33 (80.4%) non-syndromic cases of craniosynostosis while 8 (19.5%) were syndromic. Out of these 8 syndromic cases, 4 were Apert syndrome, 3 were Crouzon syndrome and 1 Pfeiffer syndrome. Phenotypically the most common non-syndromic craniosynostosis was scaphocephaly (19, 57.7%) followed by plagiocephaly in (14, 42.3%). FGFR1 mutation (Pro252Arg) was seen in 1 (2.4%) case of non-syndromic craniosynostosis while no association was noted either with FGFR1 or with FGFR2 mutation in syndromic cases. None of the control group showed any mutation.CONCLUSION:
Our study proposed that FGFR1, FGFR2 mutation, which confers predisposition to craniosynostosis does not exist in Indian population when compared to the western world. 相似文献124.
Gauri Garg Dhingra Anjali Saxena Aeshna Nigam Princy Hira Nirjara Singhvi Shailly Anand Jasvinder Kaur Jaspreet Kaur Ankita Dua Vivek Negi Vipin Gupta Utkarsh Sood Roshan Kumar Sukanya Lal Helianthous Verma Mansi Verma Priya Singh Charu Dogra Rawat Charu Tripathi Chandni Talwar Shekhar Nagar Nitish Kumar Mahato Om Prakash Mona Singh R. C. Kuhad Yogendra Singh Banwari Lal Sunil Pabbi Namita Singh V. C. Kalia Rup Lal 《Indian journal of microbiology》2021,61(2):111
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Sukanya Narasimhan Jeroen Coumou Tim J. Schuijt Eric Boder Joppe W. Hovius Erol Fikrig 《PLoS pathogens》2014,10(8)
Borrelia burgdorferi transmission to the vertebrate host commences with growth of the spirochete in the tick gut and migration from the gut to the salivary glands. This complex process, involving intimate interactions of the spirochete with the gut epithelium, is pivotal to transmission. We utilized a yeast surface display library of tick gut proteins to perform a global screen for tick gut proteins that might interact with Borrelia membrane proteins. A putative fibronectin type III domain-containing tick gut protein (Ixofin3D) was most frequently identified from this screen and prioritized for further analysis. Immunization against Ixofin3D and RNA interference-mediated reduction in expression of Ixofin3D resulted in decreased spirochete burden in tick salivary glands and in the murine host. Microscopic examination showed decreased aggregation of spirochetes on the gut epithelium concomitant with reduced expression of Ixofin3D. Our observations suggest that the interaction between Borrelia and Ixofin3D facilitates spirochete congregation to the gut during transmission, and provides a “molecular exit” direction for spirochete egress from the gut. 相似文献
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Molecular and Cellular Biochemistry - Of the various eucaryotic tissues, where glutamine synthetase (GS) mRNA and its regulation have been investigated, the induction of GS by glucocorticoids in... 相似文献
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