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Anti‐migratory activity of marine alkaloid monanchocidin A – proteomics‐based discovery and confirmation 下载免费PDF全文
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A. G. Guzii T. N. Makarieva V. I. Svetashev V. A. Denisenko P. S. Dmitrenok E. V. Pokanevich E. A. Santalova V. B. Krasokhin V. A. Stonik 《Russian Journal of Bioorganic Chemistry》2006,32(3):288-294
Total ceramides containing nonbranched and iso-branched C18-and C19-phytosphingosines acylated with nonhydroxylated fatty acids were isolated from a marine sponge Oceanapia sp. The structures of these compounds were determined by HPLC, NMR, MALDI TOF MS, and GLC-MS of the Me3Si derivatives and by chemical transformations. 相似文献
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Jun-O Jin Valeria V. Shastina Sung-Won Shin Joo-In Park Sergey A. Avilov Valentin A. Stonik Jong-Young Kwak 《FEBS letters》2009,583(4):697-34
Frondoside A is a pentaoside having an acetyl moiety at the aglycon ring and xylose as a third monosaccharide residue. Cucumarioside A2-2 is a pentaoside having glucose as a third monosaccahride unit. We compared the effects of frondoside A and A2-2 for cell death-inducing capability with close attention paid to structure-activity relationships. Both frondoside A and A2-2 strongly induced apoptosis of leukemic cells. Frondoside A-induced apoptosis was more potent and rapid than A2-2-induced apoptosis. A2-2-induced but not frondoside A-induced apoptosis was caspase-dependent. This suggests that holothurians may induce apoptosis of leukemic cells caspase-dependently or -independently, depending on the holothurian structure. 相似文献
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GUILLAUME BILLET MAËVA ORLIAC PIERRE‐OLIVIER ANTOINE CARLOS JARAMILLO 《Palaeontology》2010,53(2):319-325
Abstract: The controversial taxon Colombitherium tolimense (Mammalia) (probably Late Eocene in age) from Colombia, although known for nearly 40 years, still bears much mystery. Aside from the problematic ordinal attribution of the holotype and only specimen, its determination as an upper or lower jaw remains a highly debated issue. New observations include the presence of a contact facet on the distal face of the most posterior tooth, which indicates that the fragmentary jaw preserves three premolars and two molars; the M3, unpreserved but present, being most probably reduced. This new interpretation completely fits the morphology of the teeth. Furthermore, the shape of these latter and the deeper wear encompassed by their lingual part relative to the labial one is typical of upper dentition. This is in agreement with the internal curving of the roots of the anterior premolars and with several other arguments that lead interpreting the holotype of C. tolimense as a maxillary bearing P2‐M2. This new interpretation deepens the morphological gap between Colombitherium and other pyrotherians (except Proticia) and challenges further its referral to Pyrotheria. The peculiar morphology of Colombitherium relative to other pyrotherians is indeed striking. In fact, Colombitherium has nothing in common with pyrotherians but bilophodont cheek teeth, a feature largely widespread in placental mammals. It is here referred to ?Pyrotheria until additional evidence of its relationships is known. Associated with the putative removal of Proticia from Pyrotheria as argued by some authors, the hypothetical removal of Colombitherium from the order would adjust the widely accepted assumption that the pyrotherian bilophodont cheek teeth originated from bunodont cheek teeth. It would also make an origin from lophodont forms plausible. This in turn would have critical relevance, especially to the hypothesis that pyrotherians are notoungulates. 相似文献
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Naga VA Kommuri Sri Lakshmi S Kollepara E Saulitis MA Siddiqui 《Indian pacing and electrophysiology journal》2010,10(1):49-54
Evaluation of defibrillation threshold is a standard of care during implantation of implantable cardioverter defibrillator. High defibrillation thresholds are often encountered and pose a challenge to electrophysiologists to improve the defibrillation threshold. We describe a case series where defibrillation thresholds were improved after implanting a defibrillation lead in the azygos vein. 相似文献
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Kicha AA Kapustina II Ivanchina NV Kalinovskiííí AI Dmitrenok IS Stonik VA Pal'ianova NV Pankova TM Starostina MV 《Bioorganicheskaia khimiia》2008,34(1):129-135
Two new steroid glycosides: distolasteroside D6, (24S)-24-O-(beta-D-xylopyranosyl)-5alpha-cholestane-3beta,6alpha,8,15beta,16beta,24-hexaol, and distolasteroside D7. (22E,24R)-24-O-(beta-D-xylopyranosyl)-5alpha-cholest-22-ene-3beta,6alpha,8,15beta,24-pentaol were isolated along with the previously known distolasterosides D1, D2, and D3, echinasteroside C, and (25S)-5alpha-cholestane-3beta,4beta,6alpha,7alpha,8,15alpha,16beta,26-octaol from the Far Eastern starfish Distolasterias nipon. The structures of new compounds were elucidated by NMR spectroscopy and MALDI TOF mass spectrometry. Like neurotrophins, distolasterosides D1, D2, and D3 were shown to induce neuroblast differentiation in a mouse neuroblastoma C 1300 cell culture. 相似文献
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Sviridov DO Ikpot IZ Stonik J Drake SK Amar M Osei-Hwedieh DO Piszczek G Turner S Remaley AT 《Biochemical and biophysical research communications》2011,(3):446-451
Apolipoprotein mimetic peptides are short amphipathic peptides that efflux cholesterol from cells by the ABCA1 transporter and are being investigated as therapeutic agents for cardiovascular disease. We examined the role of helix stabilization of these peptides in cholesterol efflux. A 23-amino acid long peptide (Ac-VLEDSFKVSFLSALEEYTKKLNTQ-NH2) based on the last helix of apoA-I (A10) was synthesized, as well as two variants, S1A10 and S2A10, in which the third and fourth and third and fifth turn of each peptide, respectively, were covalently joined by hydrocarbon staples. By CD spectroscopy, the stapled variants at 24 °C were more helical in aqueous buffer than A10 (A10 17%, S1A10 62%, S2A10 97%). S1A10 and S2A10 unlike A10 were resistant to proteolysis by pepsin and chymotrypsin. S1A10 and S2A10 showed more than a 10-fold increase in cholesterol efflux by the ABCA1 transporter compared to A10. In summary, hydrocarbon stapling of amphipathic peptides increases their helicity, makes them resistant to proteolysis and enhances their ability to promote cholesterol efflux by the ABCA1 transporter, indicating that this peptide modification may be useful in the development of apolipoprotein mimetic peptides. 相似文献