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51.
Kvichansky Alexey A. Tret’yakova Liya V. Volobueva Maria N. Manolova Anna O. Stepanichev Mikhail Yu. Onufriev Mikhail V. Moiseeva Yulia V. Lazareva Natalia A. Bolshakov Alexey P. Gulyaeva Natalia V. 《Biochemistry. Biokhimii?a》2021,86(6):693-703
Biochemistry (Moscow) - Differential effect of the neonatal proinflammatory stress (NPS) on the development of neuroinflammation in the hippocampus and induction of the depressive-like behavior in... 相似文献
52.
M. V. Onufriev S. V. Freiman D. I. Peregud I. V. Kudryashova A. O. Tishkina M. Yu. Stepanichev N. V. Gulyaeva 《Biochemistry. Biokhimii?a》2017,82(3):275-281
Infectious diseases in early postnatal ontogenesis can induce neuroinflammation, disrupt normal central nervous system development, and contribute to pathogenesis of cerebral pathologies in adults. To study long-term consequences of such early stress, we induced neonatal proinflammatory stress (NPS) by injecting bacterial lipopolysaccharide into rat pups on postnatal days 3 and 5 and then assessed the levels of corticosterone, proinflammatory cytokines and their mRNAs, and neurotrophins and their mRNAs in the hippocampus and neocortex of the one-month-old animals. Long-term potentiation (LTP) was studied in hippocampal slices as an index of synaptic plasticity. NPS-induced impairments of LTP were accompanied by the accumulation of corticosterone and IL-6 in the hippocampus. In the neocortex, a decrease in exon IV BDNF mRNA was detected. We suggest that excessive corticosterone delivery to hippocampal receptors and proinflammatory changes persisting during brain maturation are among the principal molecular mechanisms responsible for NPSinduced neuroplasticity impairments. 相似文献