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291.
Michael L. Shuler 《Trends in biotechnology》1983,1(3):94-95
292.
Decomposable graphical Gaussian model determination 总被引:8,自引:0,他引:8
293.
The feasibility of using hollow fiber membrane dialyzers (C-DAK) for immobilization of microbial whole cells was investigated. The cells are located on the shell side of the dialyzer, while substrates and products are free to diffuse across the hollow fiber membranes. The biochemical reaction studied was the conversion of L -histidine to urocanic acid and catalyzed by L -histidine ammonia-lyase. C-DAK dialyzers containing a heat-treated suspension of Pseudomonas fluorescens ATCC 11299b (with L -histidine ammonia–lyase activity) were incorporated into constant volume recycle reactor systems for continuous product formation. A simple model successfully correlated the data and predicted performance. It was found that the reaction was not likely to be diffusion limited, and such a cell immobilization scheme is convenient and workable for continuous production of biochemicals. 相似文献
294.
After administration, drugs go through a complex, dynamic process of absorption, distribution, metabolism and excretion. The
resulting time-dependent concentration, termed pharmacokinetics (PK), is critical to the pharmacological response from patients.
An in vitro system that can test the dynamics of drug effects in a more systematic way would save time and costs in drug development.
Integration of microfabrication and cell culture techniques has resulted in ‘cells-on-a-chip’ technology, which is showing
promise for high-throughput drug screening in physiologically relevant manner. In this review, we summarize current research
efforts which ultimately lead to in vitro systems for testing drug’s effect in PK-based manner. In particular, we highlight
the contribution of microscale systems towards this goal. We envision that the ‘cells-on-a-chip’ technology will serve as
a valuable link between in vitro and in vivo studies, reducing the demand for animal studies, and making clinical trials more
effective. 相似文献