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201.
Dr. Shigetoshi Taguchi Associate Professor Dr. Hideshi Kobayashi Donald S. Farner 《Cell and tissue research》1966,69(1):228-245
Summary By use of a stereotaxic instrument it has been consistently possible to introduce 35S DL-cysteine into the third ventricle of the White-crowned Sparrow, Zonotrichia leucophrys gambelii. Such injections are followed within six hours by a reproducible pattern of accumulation of the isotope in the hypothalamic nuclei around the third ventricle. The nucleus supraopticus, the nucleus paraventricularis magnocellularis, the lamina terminalis, and the area ependymalis vasculosa consistently showed the greatest accumulation of the isotope. In the supraoptic and paraventricular nuclei, conspicuous accumulation of the isotope was consistently observed in association with cells containing aldehyde-fuchsin positive material. The supraoptico-hypophysial tract, the pars nervosa, and the palisade layer of the zona externa of the median eminence showed pronounced accumulations of the isotope. These accumulations were, to a great extent, associated with aldehyde-fuchsin positive neurosecretory material.Dedicatet to Professor Dr. W. Bargmann in honor of his 60th birthday.This investigation was conducted under Contract No. DA 18-108-AMC-127 (A) US Army Chemical Center Procurement Agency, Edgewood, Maryland, with Professor Farner as principal investigator. 相似文献
202.
Nobuharu Goto Takeshi Sato Minoru Shigetoshi Kiyoteru Ikegami 《Journal of chromatography. B, Analytical technologies in the biomedical and life sciences》1992,578(2)
The dioxopiperazine metabolites of quinapril in plasma and urine were extracted with hexane—dichloroethane (1:1) under acidic conditions. Following derivatization with pentafluorobenzyl bromide and purification of the desired reaction products using a column packed with silica gel, the metabolites were analysed separately by capillary column gas chromatography—electron-impact mass spectrometry with selected-ion monitoring. The limits of quantitation for the metabolites were 0.2 ng/ml in plasma and 1 ng/ml in urine. The limits of detection were 0.1 ng/ml in plasma and 0.5 ng/ml in urine, at a signal-to-noise ratio of > 3 and > 5, respectively. The proposed method is applicable to pharmacokinetic studies. 相似文献