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ABSTRACTMany species of Eudyptes penguin have shown substantial population declines and in response, there have been efforts to identify the key demographic parameters. Here, we present the demographic parameters of one of the least well known and the least abundant species of crested penguin, the endangered Fiordland crested penguin Eudyptes pachyrhynchus. A population study incorporating mark–recapture, nest occupancy and breeding success was conducted over 16 years at several sites in the northern half of the range of the species. Survival probabilities were calculated using standard Cormack–Jolly–Seber models and the Burnham Live and Dead model. The annual probability of true survival for banded birds and apparent survival for birds with transponders were both estimated at 89% during their adult years, which is similar to that reported for Eudyptes penguin species inhabiting more southerly latitudes. Annual juvenile survival was assessed for Fiordland crested penguins until their first return at 77%. The mean breeding success (0.61?±?0.02 chicks/pair) was higher than is observed for other crested penguin species, except the southern rockhopper penguin, which may be due to having lower A-egg ejection rates and higher rates of fledging two chicks per pair. Breeding success was related to the niche of predators present. 相似文献
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Scofield RH 《Arthritis research & therapy》2011,13(6):137
Treatment of Sjögren's syndrome is almost entirely symptomatic. A lack of true understanding of the underlying immunological pathology of the disease prevents directed therapy. Interleukin-21 (IL-21) is elevated in the serum of patients with this disease and is expressed by the lymphocytes infiltrating the salivary glands. The known functions of IL-21 in facilitating differentiation, proliferation, and survival of both B and T cells mesh well with the findings in Sjögren's syndrome. Demonstration of IL-21 as a fundamental aspect of the pathophysiology of Sjögren's syndrome could lead to the development of anti-IL-21 therapy for this disease. 相似文献
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Skyler P. Dillon Anil D'Souza Biji T. Kurien R. Hal Scofield 《Biotechnology journal》2009,4(8):1210-1214
C1q is of interest in systemic lupus erythematosus (SLE) research due to deficiencies in its activity being associated with the disease. Current published protocols for measuring C1q vary greatly in their results and ease of reproducibility. Due to this, average C1q concentrations have been reported between 56 and 276 μg/mL in non-SLE serum. We present an improved method for quantifying C1q concentrations, which employs a sandwich ELISA. This method has improved precision, cost efficiency, up-scaling, reproducibility, and uses significantly lesser volumes of serum sample when compared to RID and other methods for quantifying C1q. We report an average concentration of 113 ± 40 μg/mL for C1q in non-SLE serum. The assay designed here will be useful in the high-throughput measurement of serum C1q in SLE cases. 相似文献
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A M Scofield 《Comparative biochemistry and physiology. B, Comparative biochemistry》1978,59(4):295-298
1. The Pasteur effect was shown after 15 min but not after 30 min incubation of jejunal rings from normal rats. 2. During 15-30 min incubation, the rate of anaerobic lactate production decreased, while aerobic lactate production remained unchanged. Thus oxygen was necessary to maintain the functional integrity of the tissue during this period. 3. After infection with either Nematospiroides dubius or Nippostrongylus brasiliensis, the Pasteur effect could not usually be shown, mainly due to a reduced rate of anaerobic lactate production. 4. The possible relationship of the loss of the Pasteur effect to the immune response is discussed. 相似文献
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Michael S. Y. Lee Mark N. Hutchinson Trevor H. Worthy Michael Archer Alan J. D. Tennyson Jennifer P. Worthy R. Paul Scofield 《Biology letters》2009,5(6):833-837
The New Zealand (NZ) lizard fossil record is currently limited to late Quaternary remains of modern taxa. The St Bathans Fauna (early Miocene, southern South Island) extends this record to 19–16 million years ago (Myr ago). Skull and postcranial elements are similar to extant Oligosoma (Lygosominae) skinks and Hoplodactylus (Diplodactylinae) geckos. There is no evidence of other squamate groups. These fossils, along with coeval sphenodontines, demonstrate a long conservative history for the NZ lepidosaurian fauna, provide new molecular clock calibrations and contradict inferences of a very recent (less than 8 Myr ago) arrival of skinks in NZ. 相似文献