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51.
Choudhury Mitali Koduru Tejaswi Naidu Kumar Naveen Salimi Sasan Desai Kavya Prabhu Nagu Prakash Sritharan Manjula 《Biometals》2021,34(3):511-528
BioMetals - Iron-starved Mycobacterium tuberculosis utilises the carboxymycobactin-mycobactin siderophore machinery to acquire iron. These two siderophores have high affinity for ferric iron and... 相似文献
52.
Zandi Peiman Yang Jianjun Xia Xing Barabasz-Krasny Beata Możdżeń Katarzyna Puła Joanna Bloem Elke Wang Yaosheng Hussain Sajjad Hashemi Seyed Mohammad Różanowski Bartosz Li Qian 《Plant and Soil》2021,462(1-2):365-388
Plant and Soil - The contribution of sulphur (S)-induced responses to chromium (Cr) tolerance of rice plants is not yet fully elucidated. It is hypothesised that S nutrition mitigates the... 相似文献
53.
Cluster Computing - Cloud computing is a new computation technology that provides services to consumers and businesses. The main idea of Cloud computing is to present software and hardware services... 相似文献
54.
Smith EN Koller DL Panganiban C Szelinger S Zhang P Badner JA Barrett TB Berrettini WH Bloss CS Byerley W Coryell W Edenberg HJ Foroud T Gershon ES Greenwood TA Guo Y Hipolito M Keating BJ Lawson WB Liu C Mahon PB McInnis MG McMahon FJ McKinney R Murray SS Nievergelt CM Nurnberger JI Nwulia EA Potash JB Rice J Schulze TG Scheftner WA Shilling PD Zandi PP Zöllner S Craig DW Schork NJ Kelsoe JR 《PLoS genetics》2011,7(6):e1002134
Although a highly heritable and disabling disease, bipolar disorder''s (BD) genetic variants have been challenging to identify. We present new genotype data for 1,190 cases and 401 controls and perform a genome-wide association study including additional samples for a total of 2,191 cases and 1,434 controls. We do not detect genome-wide significant associations for individual loci; however, across all SNPs, we show an association between the power to detect effects calculated from a previous genome-wide association study and evidence for replication (P = 1.5×10−7). To demonstrate that this result is not likely to be a false positive, we analyze replication rates in a large meta-analysis of height and show that, in a large enough study, associations replicate as a function of power, approaching a linear relationship. Within BD, SNPs near exons exhibit a greater probability of replication, supporting an enrichment of reproducible associations near functional regions of genes. These results indicate that there is likely common genetic variation associated with BD near exons (±10 kb) that could be identified in larger studies and, further, provide a framework for assessing the potential for replication when combining results from multiple studies. 相似文献
55.
Sasan Samiei 《Ethnic and racial studies》2013,36(13):2466-2467
56.
Zahra Zandi Bahareh Kashani Davood Bashash Ensieh M. Poursani Seyed A. Mousavi Bahram Chahardoli Seyed H. Ghaffari 《Journal of cellular biochemistry》2020,121(2):1623-1634
Increasing pieces of evidence indicate that inflammatory processes facilitate tumorigenesis; tumor cells simulate the mechanisms by which innate immune cells produce pro-inflammatory cytokines to exploit them for their own survival and proliferation. Toll-like receptor 4 (TLR4), which serves as one of the most well-known receptors on the surface of the immune cells, is often expressed ectopically in the tumor cells resulting in tumor progression, invasion, and chemoresistance. In this study, we examined the anticancer effects of TAK-242, a small molecule inhibitor of TLR4, on different breast cancer cell lines: MCF7, SKBR3, MDA-MB-231, and BT-474. Our results showed that the TLR4 inhibition, as revealed by the downregulation of TLR4 downstream genes, exerted desirable cytotoxicity on the TLR4-expressing cells, at least partly, through the downregulation of EGFR and c-Myc genes. TAK-242 also inhibited the proliferation of anoikis-resistant cells and suppressed the clonal growth of the indicated cells. The results of this study propose a mechanistic pathway by which the inhibition of TLR4 using TAK-242 could augment apoptotic cell death through the alteration of both nuclear factor-кB- and p53-related apoptosis genes in breast cancer cells, especially cells with overexpression of TLR4. Taken together, this study supports the idea that the activation of inflammatory pathways may have a crucial role in breast cancer progression and the inhibition of TLR4 using TAK-242, either as a single agent or in combination, seems to be a novel promising strategy that could be clinically available in foreseeable future. 相似文献
57.
Kai Borkenhagen Hamid Reza Esmaeili Sasan Mohsenzadeh Fatemeh Shahryari Ali Gholamifard 《Environmental Biology of Fishes》2011,91(3):327-335
The diversity of cytochrome b sequences of Carasobarbus species from Iran and adjacent areas was investigated. Two divergent haplotype groups were found for C. luteus. The first one is widespread and congruent with the biogeographical hypothesis of a recent isolation among the various populations
as a consequence of rising sea levels following the last Pleistocene glaciation. The second one is restricted to the Khabur
River in Syria. The possibility that one of these groups corresponds to C. albus is discussed, but we conclude that it is more likely that C. luteus is a single species that retained two divergent mitochondrial lineages. The mitochondrial sequence diversity found for C. kosswigi and C. sublimus is high, possibly due to small population size and consequent genetic drift. Carasobarbus kosswigi is paraphyletic with respect to C. sublimus, indicating a recent speciation event of these taxa. 相似文献
58.
Sasan Partovi Anja-Carina Schulte Markus Aschwanden Daniel Staub Daniela Benz Stephan Imfeld Bj?rn Jacobi Pavel Broz Kurt A J?ger Martin Takes Rolf W Huegli Deniz Bilecen Ulrich A Walker 《Arthritis research & therapy》2012,14(5):R209
Introduction
Muscle symptoms in systemic sclerosis (SSc) may originate from altered skeletal muscle microcirculation, which can be investigated by means of blood oxygenation level dependent (BOLD) magnetic resonance imaging (MRI).Methods
After ethics committee approval and written consent, 11 consecutive SSc patients (5 men, mean age 52.6 years, mean SSc disease duration 5.4 years) and 12 healthy volunteers (4 men, mean age 45.1 years) were included. Subjects with peripheral arterial occlusive disease were excluded. BOLD MRI was performed on calf muscles during cuff-induced ischemia and reactive hyperemia, using a 3-T whole-body scanner (Verio, Siemens, Erlangen, Germany) and fat-suppressed single-short multi-echo echo planar imaging (EPI) with four different effective echo times. Muscle BOLD signal time courses were obtained for gastrocnemius and soleus muscles: minimal hemoglobin oxygen saturation (T2*min) and maximal T2* values (T2*max), time to T2* peak (TTP), and slopes of oxygen normalization after T2* peaking.Results
The vast majority of SSc patients lacked skeletal muscle atrophy, weakness or serum creatine kinase elevation. Nevertheless, more intense oxygen desaturation during ischemia was observed in calf muscles of SSc patients (mean T2*min -15.0%), compared with controls (-9.1%, P = 0.02). SSc patients also had impaired oxygenation during hyperemia (median T2*max 9.2% vs. 20.1%, respectively, P = 0.007). The slope of muscle oxygen normalization was significantly less steep and prolonged (TTP) in SSc patients (P<0.001 for both). Similar differences were found at a separate analysis of gastrocnemius and soleus muscles, with most pronounced impairment in the gastrocnemius.Conclusions
BOLD MRI demonstrates a significant impairment of skeletal muscle microcirculation in SSc. 相似文献59.
David Ando Roya Zandi Yong?Woon Kim Michael Colvin Michael Rexach Ajay Gopinathan 《Biophysical journal》2014,106(9):1997-2007
The transport of cargo across the nuclear membrane is highly selective and accomplished by a poorly understood mechanism involving hundreds of nucleoporins lining the inside of the nuclear pore complex (NPC). Currently, there is no clear picture of the overall structure formed by this collection of proteins within the pore, primarily due to their disordered nature. We perform coarse-grained simulations of both individual nucleoporins and grafted rings of nups mimicking the in vivo geometry of the NPC and supplement this with polymer brush modeling. Our results indicate that different regions or blocks of an individual NPC protein can have distinctly different forms of disorder and that this property appears to be a conserved functional feature. Furthermore, this block structure at the individual protein level is critical to the formation of a unique higher-order polymer brush architecture that can exist in distinct morphologies depending on the effective interaction energy between the phenylalanine glycine (FG) domains of different nups. Because the interactions between FG domains may be modulated by certain forms of transport factors, our results indicate that transitions between brush morphologies could play an important role in regulating transport across the NPC, suggesting novel forms of gated transport across membrane pores with wide biomimetic applicability. 相似文献
60.
Phylogenetic analysis of 155 nuclear rDNA ITS sequences among them 19 Iranian endemic genera were used to elucidate phylogenetic relationships of Old World Brassicaceae from Iran in the context of the most recent tribal system suggested by Al-Shehbaz et al. [Al-Shehbaz, I.A., Beilstein, M.A, Kellogg, E.A., 2006. Systematics and phylogeny of the Brassicaceae (Cruciferae): an overview. Plant Syst. Evol. 259, 89–120]. Iranian endemic taxa are assigned to 16 clades, 15 of these correspond to recognized tribes. Our data support the recent tribal recognition of Calepina and relatives and further indicate that the Orychophragmus clade (with Conringia planisiliqua and Orychophragmus) may be recognized as a new tribe. Our data also support the inclusion of 13 genera not previously studied, or with unresolved positions in previous phylogenetic analyses in 10 tribes with the tribal assignment given in parentheses: Acanthocardamum (Aethionemeae), Alyssopsis (Camelineae), Anastatica (Malcolmieae), Asperuginoides (Cochlearieae), Camelinopsis (Thlaspideae), Didymophysa (Thlaspideae), Dielsiocharisi (Camelineae), Lachnoloma (Anchonieae), Micrantha (Anchonieae), Noccidium (Camelineae), Octoceras (Euclidieae), Pseudofortuynia (Sisymbrieae) and Streptoloma (Euclidieae). ITS data and morphological characters further indicate that the remaining five genera, i.e., Acanthocardamum, Olimarabidopsis, Brossardia, Noccidium and Zuvanda may be subsumed under Aethionema, Alyssopsis, Noccaea, Capsella and Conringia, respectively. Alyssum, Chorispora, Fibigia and Goldbachia are paraphyletic and Conringia, Malcolmia, Matthiola are polyphyletic taxa. 相似文献