全文获取类型
收费全文 | 11215篇 |
免费 | 1153篇 |
国内免费 | 12篇 |
出版年
2023年 | 42篇 |
2022年 | 56篇 |
2021年 | 232篇 |
2020年 | 113篇 |
2019年 | 155篇 |
2018年 | 213篇 |
2017年 | 198篇 |
2016年 | 312篇 |
2015年 | 532篇 |
2014年 | 594篇 |
2013年 | 731篇 |
2012年 | 904篇 |
2011年 | 891篇 |
2010年 | 584篇 |
2009年 | 491篇 |
2008年 | 725篇 |
2007年 | 665篇 |
2006年 | 624篇 |
2005年 | 598篇 |
2004年 | 562篇 |
2003年 | 511篇 |
2002年 | 516篇 |
2001年 | 171篇 |
2000年 | 125篇 |
1999年 | 133篇 |
1998年 | 146篇 |
1997年 | 93篇 |
1996年 | 70篇 |
1995年 | 50篇 |
1994年 | 83篇 |
1993年 | 71篇 |
1992年 | 88篇 |
1991年 | 81篇 |
1990年 | 71篇 |
1989年 | 76篇 |
1988年 | 71篇 |
1987年 | 68篇 |
1986年 | 49篇 |
1985年 | 43篇 |
1984年 | 50篇 |
1983年 | 41篇 |
1982年 | 50篇 |
1981年 | 36篇 |
1980年 | 42篇 |
1979年 | 47篇 |
1978年 | 38篇 |
1977年 | 37篇 |
1974年 | 42篇 |
1972年 | 33篇 |
1970年 | 27篇 |
排序方式: 共有10000条查询结果,搜索用时 46 毫秒
991.
992.
993.
994.
995.
996.
997.
Holger Maier Christine Schütt Ralph Steinkamp Anja Hurt Elida Schneltzer Philipp Gormanns Christoph Lengger Mark Griffiths David Melvin Neha Agrawal Rafael Alcantara Arthur Evans David Gannon Simon Holroyd Christian Kipp Navis Pretheeba Raj David Richardson Sophie LeBlanc Laurent Vasseur Hiroshi Masuya Kimio Kobayashi Tomohiro Suzuki Nobuhiko Tanaka Shigeharu Wakana Alison Walling David Clary Juan Gallegos Helmut Fuchs Martin Hrabě de Angelis Valerie Gailus-Durner 《Mammalian genome》2015,26(9-10):467-481
998.
Valerie J. Morley Sandra Y. Mendiola Paul E. Turner 《Proceedings. Biological sciences / The Royal Society》2015,282(1813)
Although differing rates of environmental turnover should be consequential for the dynamics of adaptive change, this idea has been rarely examined outside of theory. In particular, the importance of RNA viruses in disease emergence warrants experiments testing how differing rates of novel host invasion may impact the ability of viruses to adaptively shift onto a novel host. To test whether the rate of environmental turnover influences adaptation, we experimentally evolved 144 Sindbis virus lineages in replicated tissue-culture environments, which transitioned from being dominated by a permissive host cell type to a novel host cell type. The rate at which the novel host ‘invaded’ the environment varied by treatment. The fitness (growth rate) of evolved virus populations was measured on each host type, and molecular substitutions were mapped via whole genome consensus sequencing. Results showed that virus populations more consistently reached high fitness levels on the novel host when the novel host ‘invaded’ the environment more gradually, and gradual invasion resulted in less variable genomic outcomes. Moreover, virus populations that experienced a rapid shift onto the novel host converged upon different genotypes than populations that experienced a gradual shift onto the novel host, suggesting a strong effect of historical contingency. 相似文献
999.
Amy J. Osborne John Pearson Sandra S. Negro B. Louise Chilvers Martin A. Kennedy Neil J. Gemmell 《Molecular ecology》2015,24(7):1419-1432
The effect of MHC polymorphism on individual fitness variation in the wild remains equivocal; however, much evidence suggests that heterozygote advantage is a major determinant. To understand the contribution of MHC polymorphism to individual disease resistance or susceptibility in natural populations, we investigated two MHC class II B loci, DQB and DRB, in the New Zealand sea lion (NZSL, Phocarctos hookeri). The NZSL is a threatened species which is unusually susceptible to death by bacterial infection at an early age; it has suffered three bacterial induced epizootics resulting in high mortality levels of young pups since 1997. The MHC DQB and DRB haplotypes of dead NZSL pups with known cause of death (bacteria, enteritis or trauma) were sequenced and reconstructed, compared to pups that survived beyond 2 months of age, and distinct MHC DRB allele frequency and genotype differences were identified. Two findings were striking: (i) one DRB allele was present only in dead pups, and (ii) one heterozygous DRB genotype, common in live pups, was absent from dead pups. These results are consistent with some functional relationship with these variants and suggest heterozygote advantage is operating at DRB. We found no association between heterozygosity and fitness at 17 microsatellite loci, indicating that general heterozygosity is not responsible for the effect on fitness detected here. This result may be a consequence of recurrent selection by multiple pathogen assault over recent years and highlights the importance of heterozygote advantage at MHC as a potential mechanism for fitness differences in wild populations. 相似文献
1000.
Johanna Chemnitz Petra C. Jentschke Manfred Ayasse Sandra Steiger 《Proceedings. Biological sciences / The Royal Society》2015,282(1812)
Long-range sex pheromones have been subjected to substantial research with a particular focus on their biosynthesis, peripheral perception, central processing and the resulting orientation behaviour of perceivers. Fundamental to the research on sex attractants was the assumption that they primarily coordinate species recognition. However, especially when they are produced by the less limiting sex (usually males), the evolution of heightened condition dependence might be expected and long-range sex pheromones might, therefore, also inform about a signaller''s quality. Here we provide, to our knowledge, the first comprehensive study of the role of a male''s long-range pheromone in mate choice that combines chemical analyses, video observations and field experiments with a multifactorial manipulation of males'' condition. We show that the emission of the long-distance sex pheromone of the burying beetle, Nicrophorus vespilloides is highly condition-dependent and reliably reflects nutritional state, age, body size and parasite load—key components of an individual''s somatic state. Both, the quantity and ratio of the pheromone components were affected but the time invested in pheromone emission was largely unaffected by a male''s condition. Moreover, the variation in pheromone emission caused by the variation in condition had a strong effect on the attractiveness of males in the field, with males in better nutritional condition, of older age, larger body size and bearing less parasites being more attractive. That a single pheromone is influenced by so many aspects of the somatic state and causes such variation in a male''s attractiveness under field conditions was hitherto unknown and highlights the need to integrate indicator models of sexual selection into pheromone research. 相似文献