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361.
362.
J. S. Amenta M. J. Sargus F. M. Baccino C. Sacchi G. Bonelli 《In vitro cellular & developmental biology. Animal》1993,29(11):855-861
Summary The purpose of this study was to characterize the stages in the development of thymidine-induced cell death. L-cells were
characterized by both morphologic and quantitative techniques and evaluated at 24, 48, and 72 h of treatment. Cells first
enlarged (stage I); about 50% of these enlarged cells then decreased in size with blebbing and compacting (stage II). This
residual cell body transformed into a smooth eosinophilic hyaline body (stage III) by 72 h, many of which could be identified
within the vacuolar system of viable cells. These changes were reflected in morphologic counts and Coulter sizing. Cell death
(loss of labeled DNA) began in stage II and was most prominent in stage III. No cleavage of DNA into oligonucleosomal fragments
was detected by agarose gel electrophoresis at any stage. The similarity of these changes to the complete spectrum of apoptosis
in vivo is discussed. 相似文献
363.
Ravizzola Giuseppe Sacchi Giuseppe Peroni Laura Pizzi Raul Turano Adolfo 《Current microbiology》1994,29(4):237-240
The protective effects of ciprofloxacin and rufloxacin were compared to those of rifampicin againstMycobacterium tuberculosis infections in mice and in guinea pigs. Rifampicin was very protective in both models. In tubercular infections produced in mice, ciprofloxacin (30 mg/kg) showed slight protection but none was observed in guinea pigs. Rufloxacin, was weakly active in guinea pigs but inactive in mice. 相似文献
364.
G. Simoni L. Larizza N. Sacchi G. Della Valle F. Dambrosio L. De Carli 《Human genetics》1979,49(3):327-332
Summary The frequencies of chromosome lesions were determined on 3537 mitoses in samples of varying sizes from cultures of 25 amniotic fluid specimens taken from patients at cytogenetic risk. The average percentage values of aberrant cells, including and excluding gaps, were 12.5 and 4.9, respectively. The corresponding values for fibroblasts and peripheral blood lymphocytes from normal adult donors, calculated under the same laboratory conditions, were 5.0 (including gaps) and 2.4 (excluding gaps) and 2.4 (including gaps) and 1.0 (excluding gaps), respectively. The hypothesis of a correlation between the increased incidence of chromosome lesions and the occurrence of abnormal karyotypes in amniotic fluid cell cultures is discussed. 相似文献