Viral infection induces the initiation of antiviral effectors and cytokines which are critical mediators of innate antiviral responses.The critical molecular determinants are responsible for triggering an appropriate immune response. Long noncoding RNAs(lncRNAs) have emerged as new gene modulators involved in various biological processes, while how lncRNAs operate in lower vertebrates are still unknown. Here, we discover a long noncoding RNA, termed antiviral-associated long noncoding RNA(AANCR), as a novel regulator for innate antiviral responses in teleost fish. The results indicate that fish MITA plays an essential role in host antiviral responses and inhibition of Siniperca chuatsi rhabdovirus(SCRV) production. miR-210 reduces MITA expression and suppress MITA-mediated antiviral responses, which may help viruses evade host antiviral responses. Further,AANCR functions as a competing endogenous RNA(ceRNA) for miR-210 to control protein abundance of MITA, thereby inhibiting SCRV replication and promoting antiviral responses. Our data not only shed new light on understanding the function role of lncRNA in biological processes in teleost fish, but confirmed the hypothesis that ceRNA networks exist widely in vertebrates. 相似文献
为探明三氟苯嘧啶不同种子处理方式对稻飞虱的田间防治效果、防治时长以及对稻田蜘蛛和水稻的安全性,为该药剂种子处理防治稻飞虱提供科学依据,本研究设置10％三氟苯嘧啶悬浮剂按不同浓度(0.375、0.75、1.125和1.5 g a.i./kg种子)对水稻种子分别以干种子拌种(干拌)、清水浸种后拌种(湿拌)和药剂浸种3种方式,清水处理作为空白对照.结果表明,3种处理方式下的水稻发芽率和出苗率均与空白对照间无显著差异,播种后100 d,各浓度对稻飞虱的防治效果均在90％以上;当药剂浓度相同时,干拌与湿拌防治时长要优于药剂浸种;不同浓度三氟苯嘧啶药剂处理在3种方式下稻田蜘蛛种群数量均略低于空白对照田蜘蛛数量.因此,水稻生产中使用三氟苯嘧啶0.375～1.5 g a.i./kg种子干拌或湿拌处理,可有效降低田间稻飞虱种群数量,对天敌蜘蛛影响较小,对水稻种子发芽、出苗安全,可在水稻生产中推广使用. 相似文献
As the most important construction features of ancient Chinese cities, the city walls nowadays have lost their function of enemy defense and turned to affect the urban structure and development. To clarify the impact of ancient city walls on modern urban development, this work was conducted to measure the differences of landscape types and levels between the inner and outer walls of three typical ancient Chinese cities with the help of geoinformatics materials and landscape ecology indices. The results of this research proved that city walls have great impact on landscape pattern. Specifically, the aggregation, fragmentation, diversity and evenness of landscape were strongly affected by well-preserved ancient city walls. By sorting out and consulting historical documents and China's “City Walls Protection Regulations”, we also found that city walls help the old city to retain its original style and design characteristics. The findings of this quantitative-analysis-based historical study can provide a theoretical basis for the protection of historical heritage and landscape design.
