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71.
72.
Zhifeng Yun Zhou Lei Gabrielle Allen Daniel S. Katz J. Ramanujam 《Cluster computing》2014,17(2):371-387
The availability of a large number of separate clusters has given rise to the field of multicluster systems in which these resources are coupled to obtain their combined benefits to solve large-scale compute-intensive applications. However, it is challenging to achieve automatic load balancing of the jobs across these participating autonomic systems. We developed a novel user space execution model named DA-TC to address the workload allocation techniques for the applications with large number of sequential jobs in multicluster systems. Through this model, we can achieve dynamic load balancing for task assignment, and slower resources become beneficial factors rather than bottlenecks for application execution. The effectiveness of this strategy is demonstrated through theoretical analysis. This model is also evaluated through extensive experimental studies and the results show that when compared with the traditional method, the proposed DA-TC model can significantly improve the performance of application execution in terms of application turnaround time and system reliability in multicluster circumstances. 相似文献
73.
74.
Kumar A Singhal NK Ramanujam B Mitra A Rameshwaram NR Nadimpalli SK Rao CP 《Glycoconjugate journal》2009,26(4):495-510
Several C1-imino conjugates of d-galactose, d-lactose and d-ribose, where the nitrogen center was substituted by the salicylidene or naphthylidene, were synthesized and characterized.
Similar C2-imino conjugates of d-glucose have also been synthesized. All the glyco-imino-conjugates, which are transition state analogues, exhibited 100%
inhibition of the activity towards glycosidases extracted from soybean and jack bean meal. Among these, a galactosyl-napthyl-imine-conjugate
(1c) showed 50% inhibition of the activity of pure α-mannosidase from jack bean at 22 ± 2.5 μM, and a ribosyl-naphthyl-imine-conjugate
(3c) showed at 31 ± 5.5 μM and hence these conjugates are potent inhibitors of glycosidases. The kinetic studies suggested non-competitive
inhibition by these conjugates. The studies are also suggestive of the involvement of aromatic, imine and carbohydrate moieties
of the glyco-imino-conjugates in the effective inhibition. The binding of glyco-imino-conjugate has been established by extensive
studies carried out using fluorescence emission and isothermal titration calorimetry. The conformational changes resulted
in the enzyme upon interaction of these derivatives has been established by studying the fluorescence quench of the enzyme
by KI as well as from the secondary structural changes noticed in CD spectra. All these studies revealed the difference in
the binding strengths of the naphthylidene vs. salicylidene as well as galactosyl vs. lactosyl moieties present in these conjugates. The differential inhibition of these glyco-conjugates has been addressed by
quantifying the specific interactions present between the glyco-conjugates and the enzyme by using rigid docking studies.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
75.
Polyhydroxyalkanoates (PHAs) are biodegradable polymers produced by microbes to overcome environmental stress. Commercial
production of PHAs is limited by the high cost of production compared to conventional plastics. Another hindrance is the brittle
nature and low strength of polyhydroxybutyrate (PHB), the most widely studied PHA. The needs are to produce PHAs, which have
better elastomeric properties suitable for biomedical applications, preferably from inexpensive renewable sources to reduce
cost. Certain unique properties of Bacillus subtilis such as lack of the toxic lipo-polysaccharides, expression of self-lysing genes on completion of PHA biosynthetic process
– for easy and timely recovery, usage of biowastes as feed enable it to compete as potential candidate for commercial production
of PHA. 相似文献
76.
Sheran HW Law Rudolf SS Wu Patrick KS Ng Richard MK Yu Richard YC Kong 《BMC molecular biology》2006,7(1):15-13
Background
Hypoxia-inducible factors (HIFs) are involved in adaptive and survival responses to hypoxic stress in mammals. In fish, very little is known about the functions of HIFs. 相似文献77.
Singh SK Vobbalareddy S Kalleda SR Casturi SR Datla SR Mamidi RN Mullangi R Ramanujam R Yeleswarapu KR Iqbal J 《Bioorganic & medicinal chemistry》2006,14(24):8626-8634
Synthesis of prodrugs of orally active COX-2 inhibitor 3 involving sulfamoyl (SO2NH2) and hydroxymethyl (CH2OH) groups, and their biological evaluation are described. Of these prodrugs, the N-propionyl sulfonamide sodium 3k was found to be much superior to the parent compound 3 and other marketed COX-2 inhibitors in carrageenan induced rat paw edema model of inflammation due to highly elevated drug levels in systemic circulation. This prodrug has a potential both for oral as well as parenteral administration due to impressive analgesic activity, antipyretic potency, and extraordinary water solubility. 相似文献
78.
Altering the lectin properties by chemically modified glycoconjugates can have profound effect on their biological applications. In the present case, jacalin has been chosen to study the binding aspects toward glycoconjugates modified by connecting aromatic moieties through imine conjugation at their C-1- or C-2-positions. Out of 10 glycoconjugates, the galactosyl-naphthyl imine (1c) was found to be most effective toward agglutination inhibition (260 times better than galactose), quenching fluorescence intensity, and exhibiting greater binding (Ka, 1.3 × 104 M−1) with jacalin. The specific binding of galactose conjugates and the nonspecific binding of other conjugates have been demonstrated based on ITC. Changes in the secondary structures have been addressed by far- and near-UV CD spectroscopy. The present studies demonstrated that galactose-based conjugates bind at carbohydrate recognition domain (CRD) mainly through polar interactions in addition to exhibiting some nonpolar/hydrophobic interactions, whereas the conjugates other than galactose primarily interact through hydrophobic interactions. Binding of galactosyl conjugates at CRD has been further demonstrated by rigid docking. 相似文献
79.
Ravikrishna Ramanujam Meredith E. Calvert Poonguzhali Selvaraj Naweed I. Naqvi 《PLoS pathogens》2013,9(8)
In Magnaporthe oryzae, the causal ascomycete of the devastating rice blast disease, the conidial germ tube tip must sense and respond to a wide array of requisite cues from the host in order to switch from polarized to isotropic growth, ultimately forming the dome-shaped infection cell known as the appressorium. Although the role for G-protein mediated Cyclic AMP signaling in appressorium formation was first identified almost two decades ago, little is known about the spatio-temporal dynamics of the cascade and how the signal is transmitted through the intracellular network during cell growth and morphogenesis. In this study, we demonstrate that the late endosomal compartments, comprising of a PI3P-rich (Phosphatidylinositol 3-phosphate) highly dynamic tubulo-vesicular network, scaffold active MagA/GαS, Rgs1 (a GAP for MagA), Adenylate cyclase and Pth11 (a non-canonical GPCR) in the likely absence of AKAP-like anchors during early pathogenic development in M. oryzae. Loss of HOPS component Vps39 and consequently the late endosomal function caused a disruption of adenylate cyclase localization, cAMP signaling and appressorium formation. Remarkably, exogenous cAMP rescued the appressorium formation defects associated with VPS39 deletion in M. oryzae. We propose that sequestration of key G-protein signaling components on dynamic late endosomes and/or endolysosomes, provides an effective molecular means to compartmentalize and control the spatio-temporal activation and rapid downregulation (likely via vacuolar degradation) of cAMP signaling amidst changing cellular geometry during pathogenic development in M. oryzae. 相似文献
80.
The present investigation gives the length‐weight relationship (LWR) of Puntius shalynius in Meghalaya, India. The samples for the study were collected from Umiam river. The value of the exponent ‘b’ in the LWR was less than 3, with 0.885 for males and 1.616 in females. This shows that the species exhibit allometric growth pattern. There was no difference in LWR between sexes and seasons. 相似文献