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VESELOV II 《Mikrobiologiia》1951,20(6):550-555
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Tadeusz Kolodka Matthew L. Charles Arvind Raghavan Ilian A. Radichev Christina Amatya Jacob Ellefson Alexei Y. Savinov Abhijeet Nag Mark S. Williams Mark S. Robbins 《PloS one》2014,9(8)
Modulation of the kallikrein-kinin system (KKS) has been shown to have beneficial effects on glucose homeostasis and several other physiological responses relevant to the progression of type 2 diabetes mellitus (T2D). The importance of bradykinin and its receptors in mediating these responses is well documented, but the role of tissue kallikrein-1, the protease that generates bradykinin in
situ, is much less understood. We developed and tested DM199, recombinant human tissue kallikrein-1 protein (rhKLK-1), as a potential novel therapeutic for T2D. Hyperinsulinemic-euglycemic clamp studies suggest that DM199 increases whole body glucose disposal in non-diabetic rats. Single-dose administration of DM199 in obese db/db mice and ZDF rats, showed an acute, dose-dependent improvement in whole-body glucose utilization. Sub-acute dosing for a week in ZDF rats improved glucose utilization, with a concomitant rise in fasting insulin levels and HOMA1-%B scores. After cessation of sub-acute dosing, fasting blood glucose levels were significantly lower in ZDF rats during a drug wash-out period. Our studies show for the first time that DM199 administration results in acute anti-hyperglycemic effects in several preclinical models, and demonstrate the potential for further development of DM199 as a novel therapeutic for T2D. 相似文献
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SO2 污染油菜对桃蚜的影响 总被引:1,自引:0,他引:1
SO_2污染油菜对桃蚜的影响龚佩瑜,吴坤君,李秀珍(中国科学院动物研究所北京100080)SO2是我国大气污染的主要成分,它是一种对生物影响很大的污染物。so。曾被用作熏蒸剂来防治害虫,但只有在浓度很高时才有效。更多的观察表明,so:污染有利于蚜虫的?.. 相似文献
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