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331.
Cell-free protein synthesis in heart and skeletal muscles from polymyopathic hamsters 总被引:2,自引:2,他引:0 下载免费PDF全文
1. Cell-free protein synthesis was studied in striated and smooth muscles in an attempt to elucidate the primary genetic defect in polymyopathic hamsters. 2. When washed membrane-free polyribosomes from myopathic and control heart muscle were individually recombined with pH5 enzymes from both types of animals, the pH5 enzymes from myopathic muscle were less active in polypeptide synthesis than those from controls, irrespective of the source of polyribosomes. 3. The same defect was present in skeletal-muscle preparations. 4. Both the initial rate and the maximum extent of incorporation were affected in the defective preparations from myopathic muscle. 5. Concentration differences, with respect to total protein and RNA, were not responsible. 6. Preincubation of the pH5 enzymes resulted in a greater degree of inhibition. 7. The defect in the pH5 enzymes from myopathic muscle was also expressed in poly(U)-directed polyphenylalanine synthesis. 8. Acid proteinase activity in extracts of control and myopathic muscle was the same but general ribonuclease activity in the latter extracts was higher. 9. The defect was also present when both types of pH5 enzymes were prepared in the presence of the ribonuclease-asborbent bentonite. 10. pH5 enzymes from uterine smooth muscle, brains and livers of myopathic animals were similarly affected in homologous and heterologous combinations. 11. It is concluded that the general tissue defect is both qualitative and quantitative in nature, implying that there is a shortage of some essential soluble component in the pH5 fraction which is accompanied by the presence of an altered substituent. This prevents the attainment of extents of polypeptide synthesis in vitro obtained in control extracts from unaffected animals. 相似文献
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Daniela Stadler Martin Kchele Alisha N Jones Julia Hess Christian Urban Jessica Schneider Yuchen Xia Andreas Oswald Firat Nebioglu Romina Bester Felix Lasitschka Marc Ringelhan Chunkyu Ko WenMin Chou Arie Geerlof Maarten A van de Klundert Jochen M Wettengel Peter Schirmacher Mathias Heikenwlder Sabrina Schreiner Ralf Bartenschlager Andreas Pichlmair Michael Sattler Kristian Unger Ulrike Protzer 《EMBO reports》2021,22(6)
335.
Population censuses of the Antarctic fur seal (Arctocephalus gazella) and the sub-Antarctic fur seal (A. tropicalis) were conducted during the 1994/1995 breeding season at Marion Island. Pup numbers, determined from direct counts and a mark-recapture
experiment, were used to estimate population sizes. Pup numbers of A. tropicalis showed a mean annual change of 2.0% over the previous 6 years, culminating in an estimated total population of 49, 523 for
1994/1995. The population appears to be entering the maturity phase of population growth and may therefore have recovered
from the effects of uncontrolled sealing that ended in the early twentieth century. Numbers at the major colonies on Marion
Island showed little change since 1989 and these sites may have reached carrying capacity. The extension of breeding to other
parts of the island continues. Over the same period, A. gazella pup numbers showed a mean annual change of 17% and the total population numbered 1,205 in 1994/1995. This species has possibly
entered the rapid recolonisation phase of population growth. A few hybrid seals were found.
Received: 25 October 1995/Accepted: 14 April 1996 相似文献