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LAWRENCE C. WATSON 《American anthropologist》1972,74(5):1189-1207
The results of this study indicate that urbanization has the effect of significantly altering the Guajiro's sense of ideal and feared identity. It was hypothesized that an attempt would be made to minimize dissonance between the ideal and the real or "true" self which the individual privately acknowledges. However, there is found to be considerable dissonance between ideal and real identities, with the latter actually including many components of feared identity. Defective socialization in the city is suggested as a possible reason for failure to achieve ideal standards. 相似文献
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Brunner RM Srikanchai T Murani E Wimmers K Ponsuksili S 《Molecular biology reports》2012,39(1):97-107
Six genes that were known to exhibit expression levels that are correlated to drip loss BVES, SLC3A2, ZDHHC5, CS, COQ9, and
EGFR have been for candidate gene analysis. Based on in silico analysis SNPs were detected, confirmed by sequencing, and used for genotyping. The SNPs were genotyped in about 1,800 animals
from six pig populations including commercial herds of Pietrain (PI) and German Landrace (DL), different commercial herds
of Pietrain × (German Large White × German Landrace) (PIF1(a/b/c)), and one experimental F2-population Duroc × Pietrain (DUPI). Comparative and genetic mapping established the location of BVES on SSC1, of SLC3A2 and
ZDHHC5 on SSC2, of CS on SSC5, of COQ9 on SSC6 and of EGFR on SSC9, respectively, coinciding with QTL regions for carcass
and meat quality traits. BVES, SLC3A2, and CS revealed association at least with drip loss and with several other measures
of water holding capacity (WHC). Moreover, COQ9 and EGFR were associated with several meat quality traits such as meat color
and/or thawing loss. This study reveals statistic evidence in addition to the functional relationship of these genes to WHC
previously evidenced by expression analysis. This study reveals positional and genetic statistical evidence for a link of
genetic variation at these loci or close to them and promotes those six candidate genes as functional and/or positional candidate
genes for meat quality traits. 相似文献
988.
One novel approach for the biological delivery of peptide drugs is to incorporate the sequence of the peptide into the structure of a natural transport protein such as human serum transferrin (HST). However, a potential drawback is that the HST may increase the immunoreactivity of the peptide, in the same way that carrier proteins can be used to generate highly immunogenic peptide hapten conjugates. In this study we have generated a recombinant HST carrier protein that contains a peptide substrate of HIV-1 protease (VSQNYPIVL). The protein retained native HST function, and the peptide was surface exposed since it was immunoreactive in native dot blots, and was cleaved by HIV-1 protease. Immunisation of rabbits with the recombinant protein elicited only a very poor anti-peptide immune response. In contrast, strong anti-peptide immune responses were raised against both the peptide alone, and a chemical conjugate of the peptide with HST. These data demonstrate that it is possible to attenuate the immune response normally directed against an immunogenic peptide sequence by engineering into a surface exposed loop of HST. These findings may have an important impact on the future design of peptide delivery systems. 相似文献
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FRANÇOIS MUNOZ THIERRY PAILLER INGRID KOTTKE CÉDRIC GONNEAU MARC‐ANDRÉ SELOSSE 《Molecular ecology》2012,21(20):5098-5109
Characterizing the architecture of bipartite networks is increasingly used as a framework to study biotic interactions within their ecological context and to assess the extent to which evolutionary constraint shape them. Orchid mycorrhizal symbioses are particularly interesting as they are viewed as more beneficial for plants than for fungi, a situation expected to result in an asymmetry of biological constraint. This study addressed the architecture and phylogenetic constraint in these associations in tropical context. We identified a bipartite network including 73 orchid species and 95 taxonomic units of mycorrhizal fungi across the natural habitats of Reunion Island. Unlike some recent evidence for nestedness in mycorrhizal symbioses, we found a highly modular architecture that largely reflected an ecological barrier between epiphytic and terrestrial subnetworks. By testing for phylogenetic signal, the overall signal was stronger for both partners in the epiphytic subnetwork. Moreover, in the subnetwork of epiphytic angraecoid orchids, the signal in orchid phylogeny was stronger than the signal in fungal phylogeny. Epiphytic associations are therefore more conservative and may co‐evolve more than terrestrial ones. We suggest that such tighter phylogenetic specialization may have been driven by stressful life conditions in the epiphytic niches. In addition to paralleling recent insights into mycorrhizal networks, this study furthermore provides support for epiphytism as a major factor affecting ecological assemblage and evolutionary constraint in tropical mycorrhizal symbioses. 相似文献
990.