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Specific chromosomal affinity of a resistant factor 总被引:14,自引:0,他引:14
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Lela Jackson Androniqi Qifti Katherine M. Pearce Suzanne Scarlata 《Protein science : a publication of the Protein Society》2020,29(6):1258-1268
Some proteins can serve multiple functions depending on different cellular conditions. An example of a bifunctional protein is inositide‐specific mammalian phospholipase Cβ (PLCβ). PLCβ is activated by G proteins in response to hormones and neurotransmitters to increase intracellular calcium. Recently, alternate cellular function(s) of PLCβ have become uncovered. However, the conditions that allow these different functions to be operative are unclear. Like many mammalian proteins, PLCβ has a conserved catalytic core along with several regulatory domains. These domains modulate the intensity and duration of calcium signals in response to external sensory information, and allow this enzyme to inhibit protein translation in a noncatalytic manner. In this review, we first describe PLCβ's cellular functions and regulation of the switching between these functions, and then discuss the thermodynamic considerations that offer insight into how cells manage multiple and competitive associations allowing them to rapidly shift between functional states. 相似文献
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Parker Camille Zhao Jing Pearce David A. Kovács Attila D. 《Archives of microbiology》2021,203(1):85-96
Archives of Microbiology - Accumulated evidence indicates that the gut microbiota affects brain function and may be altered in neurological diseases. In this study, we analyzed the gut microbiota... 相似文献
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G. S. Voronov M. S. Berezhetskii Yu. F. Bondar’ I. Yu. Vafin D. G. Vasil’kov E. V. Voronova S. E. Grebenshchikov I. A. Grishina N. F. Larionova A. A. Letunov V. P. Logvinenko A. I. Meshcheryakov E. I. Pleshkov Yu. V. Khol’nov O. I. Fedyanin V. A. Tsygankov S. V. Shchepetov V. A. Kurnaev I. V. Vizgalov V. A. Urusov I. A. Sorokin F. S. Podolyako A. Antipenkov R. Pearce L. Worth 《Plasma Physics Reports》2013,39(4):277-288
Results are presented from L-2M stellarator experiments on testing a possible method for detection of water microleakages in the cooling system of the first wall and vacuum chamber of ITER. The method consists in the spectroscopic detection of spectral lines of the OH hydroxyl, which forms via the dissociation of water molecules in plasma. Emission in the spectral band of 305–310 nm can be detected even at water leakage rates less than 10?4 Pa m3/s. Chemical reactions between water and boron compounds on the vacuum chamber wall delay the detection of leakages up to ~2000 s. A similar phenomenon can be expected when a leakage will occur in ITER, where the materials suggested for the first wall (Be, Li) can also chemically react with water. 相似文献
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